Melatonin protects against pressure ulcer-induced oxidative injury of the skin and remote organs in rats

Journal of Pineal Research

Volumn 40, Issue 3, 2006, Pages 280-287

  Şener, Göksel ^a   Sert, Gülten ^a   Ozer Sehirli A ^a   Arbak, Serap ^a   Gedik, Nursal ^b   Ayanoǧlu Dülger, Gül ^a  

^a MARMARA UNIVERSITY   (Turkey)

^b KASIMPASA MILITARY HOSPITAL   (Turkey)

Author keywords

Antioxidant; Decubitus ulcer; Glutathione; Lipid peroxidation; Melatonin; Myeloperoxidase

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; COLLAGEN; CREATININE; GLUTATHIONE; LACTATE DEHYDROGENASE; MALONALDEHYDE; MELATONIN; MYELOPEROXIDASE; NITROGEN; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DECUBITUS; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; ILEUM; INTESTINE INJURY; ISCHEMIA; KIDNEY INJURY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID PEROXIDATION; LIVER INJURY; LUNG INJURY; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; RAT; REPERFUSION INJURY; SKIN INJURY; STOMACH INJURY; TISSUE LEVEL; TREATMENT OUTCOME; UREA NITROGEN BLOOD LEVEL; VISCERA;

ADMINISTRATION, TOPICAL; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BLOOD UREA NITROGEN; CREATINE; FEMALE; GLUTATHIONE; INJECTIONS, INTRAPERITONEAL; KIDNEY DISEASES; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; LIVER DISEASES; MAGNETICS; MALE; MALONDIALDEHYDE; MELATONIN; PEROXIDASE; PRESSURE ULCER; RATS; RATS, WISTAR; REPERFUSION INJURY; SKIN;

EID: 33644799858     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2005.00313.x     Document Type: Article

References (43)

1. C renshaw RP V istnes LM. A decade of pressure sore research: 1977-1987 J Rehabil Res Dev 1989 26 63 74
2. K osiak M. Etiology and pathology of ischemic ulcers Arch Phys Med Rehabil 1959 40 62 69
3. H ouwing R O vergoor M K on M J ansen G V an A sbeck BS H aalboom JR. Pressure-induced skin lesions in pigs: reperfusion injury and the effects of vitamin E J Wound Care 2000 9 36 40
4. W erns SW L ucchesi BR. Free radical and ischemic tissue injury Trends Pharmacol Sci 1990 11 161 166
5. G ranger DN K orthuis RJ. Physiological mechanisms of postischemic tissue injury Annu Rev Physiol 1995 57 311 332
6. K ettle AJ W interbourn CC. Myeloperoxidase: a key regulator of neutrophil oxidant roduction Redox Rep 1997 3 3 15
7. S undin BM H ussein MA G lasofer S et al. The role of allopurinol and deferoxamine in preventing pressure ulcers in pigs Plast Reconstr Surg 2000 105 1408 1421
8. T an DX P oeggeler B R eiter RJ. The pineal hormone melatonin inhibits DNA adduct formation induced by the chemical carcinogen safrole in vivo Cancer Lett 1993 70 65 71
9. T an DX C hen LD P oeggeler B M anchester LC R eiter RJ. Melatonin: a potent, endogenous hydroxyl radical scavenger Endocr J 1993 1 57 60
10. M elchiorri D R eiter RJ S ewerynek E. Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions FASEB J 1995 9 1205 1210
11. H andeland R. Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance Endocrine 2005 27 119 130
12. Ş ener G Ş ehirli AO K eyer -U ysal M A rbak S E rsoy Y Y eǧen BÇ. The protective effect of melatonin on renal ischemia-reperfusion in rat J Pineal Res 2002 32 120 126
13. Ş ener G J ahovic N T osun O A tasoy B Y eǧen BÇ. Melatonin ameliorates ionizing radiation-induced oxidative organ damage in rats Life Sci 2003 374 563 572
14. O nuki J A lmeida EA M edeiros MN D i M ascio P. Inhibition of 5-aminolevulinic acid-induced DNA damage by melatonin, N1-acetyl-N2-formyl-5- methoxykynuramine, quercetin or resveratrol J Pineal Res 2005 38 107 115
15. S ilva SO R odrigues MR C arvalho SR C atalani LH C ampa A X imenes VF. Oxidation of melatonin and its catabolites, N1-acetyl-N2 -formyl-5- methoxykynuramine and N1-acetyl-5-methoxykynuramine, by activated leukocytes J Pineal Res 2004 37 171 175
16. P oeggeler B S aarela S R eiter RJ et al. Melatonin - a highly potent endogenous radical scavenger and electron donor: new aspects of the oxidation chemistry of this indole accessed in vitro Ann N Y Acad Sci 1994 738 419 420
17. P ieri C M arra M M oroni F et al. Melatonin: a peroxyl radical scavenger more effective than vitamin E Life Sci 1994 55 PL271 276
18. G ilad E C uzzocrea S Z ingarelli B S alzman AL. Melatonin is a scavenger of peroxynitrite Life Sci 1997 60 169 174
19. R odriguez C M ayo JC S ainz RM et al. Regulation of antioxidant enzymes: a significant role for melatonin J Pineal Res 2004 36 1 9
20. R eiter RJ T an DX O suna C et al. Actions of melatonin in the reduction of oxidative stress J Biomed Sci 2000 7 444 458
21. P eirce SM S kalak TC R ieger JM M acdonald TL L inden J. Selective A(2A) adenosine receptor activation reduces skin pressure ulcer formation and inflammation Am J Physiol Heart Circ Physiol 2001 281 H67 74
22. R atliff CR D onovan A S chuch J R odeheaver GT. Hospital replacement mattresses: do they stand the test of time In: 30th Annual Wound Ostomy and Continence Conference Salt Lake City, UT 1998 p. 7
23. T alke H S chubert GE. Enzymatic urea determination in the blood and serum in the Warburg optical test Klin Wochenschr 1965 43 174 175
24. M oss DW H enderson AR K achmar JF. Enzymes In Fundamentals of Clinical Chemistry Ed Tietz NW WB Saunders Company Philadelphia 1987 pp 372 373
25. S lot C. Plasma creatinine determination. A new and specific Jaffe reaction method Scand J Clin Lab Invest 1965 17 381 387
26. M artinek RG. A rapid ultraviolet spectrophotometric lactic dehydrogenase assay Clin Chem Acta 1972 40 91 99
27. B euge JA A ust SD. Microsomal lipid peroxidation Methods Enzymol 1978 53 302 311
28. B eutler E. Glutathione in Red Blood Cell Metabolism. A Manual of Biochemical Methods Grune & Stratton New York 1975 pp 112 114
29. B radley PP P riebat DA C hristersen RD R othstein G. Measurement of cutaneous inflammation. Estimation of neutrophil content with an enzyme marker J Invest Dermatol 1982 78 206 209
30. H illegas LM G riswold DE B rickson B A lbrightson -W inslow C. Assessment of myeloperoxidase activity in whole rat kidney J Pharmacol Methods 1990 24 285 295
31. L opez D e L eon A R ojkind M. A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections J Histochem Cytochem 1985 33 737 743
32. S en CK K hanna S G ordillo G B agchi D B agchi M R oy S. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm Ann N Y Acad Sci 2002 957 239 249
33. H unt TK H opf H H ussain Z. Physiology of wound healing Adv Skin Wound Care 2000 13 2 Suppl. 6 11
34. P arks DA G ranger DN. Ischemia-reperfusion injury: a radical view Hepatology 1988 8 680 682
35. Z immerman BJ G risham MB G ranger DN. Role of oxidants in ischemia-reperfusion induced granulocyte infiltration Am J Physiol 1990 258 G185 G190
36. L aight DW L ad N W oodward B W aterfall JF. Assesment of myeloperoxidase activity in renal tissue after ischemia/reperfusion Eur J Pharmacol 1994 292 81 88
37. R oss D. Glutathione, free radicals and chemotherapeutic agents Pharmacol Ther 1988 37 231 249
38. R eiter RJ T an DX M anchester LC Q i W. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence Cell Biochem Biophys 2001 34 237 256
39. P ierrefiche G T opall G C ourboin G H enriet I L aborit H. Antioxidant activity of melatonin in mice Res Commun Chem Pathol Pharmacol 1993 80 211 223
40. G arcia JJ R eiter RJ G uerrero JM et al. Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation FEBS Lett 1997 408 297 300
41. l eon J A cuna -C astroviejo D E scames G T an DX R eiter RJ. Melatonin mitigates mitochondrial malfunction J Pineal Res 2005 38 1 9
42. R eiter RJ T an DX M anchester LC L opez -B urillo S S ainz RM M ayo JC. Melatonin: detoxification of oxygen and nitrogen-based toxic reactants Adv Exp Med Biol 2003 527 539 548
43. A cuna -C astroviejo D M artin M M acias M et al. Melatonin, mitochondria and cellular bioenergetics J Pineal Res 2001 30 65 74