Successful autologous stem cell transplantation in a severely immunocompromised patient with relapsed AIDS-related B-cell lymphoma

European Journal of Medical Research

Volumn 11, Issue 2, 2006, Pages 73-76

  Hoffmann, Christian ^a,b   Repp, R ^a   Schoch, R ^a   Gahn, B ^a   Schub, N ^a   Beck, C ^a   Humpe, A ^a   Kneba, M ^a   Horst, H A ^a   Schmitz, N ^c   Gramatzki, M ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b Ifi Institute   (Germany)

^c DEPARTMENT OF CARDIOLOGY   (Germany)

Author keywords

Autologous stem cell transplantation; HAART; HIV AIDS; Lymphoma

Indexed keywords

CARBOPLATIN; CARMUSTINE; CYCLOPHOSPHAMIDE; CYTARABINE; DOXORUBICIN; EFAVIRENZ; ETOPOSIDE; IFOSFAMIDE; LAMIVUDINE; MELPHALAN; PREDNISONE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RITUXIMAB; TENOFOVIR; VINCRISTINE;

ADULT; AIDS RELATED COMPLEX; AUTOLOGOUS STEM CELL TRANSPLANTATION; B CELL LYMPHOMA; CANCER COMBINATION CHEMOTHERAPY; CANCER RECURRENCE; CASE REPORT; CD4 LYMPHOCYTE COUNT; DISEASE SEVERITY; FEVER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOSUPPRESSIVE TREATMENT; MALE; MUCOSA INFLAMMATION; PNEUMOCYSTIS PNEUMONIA; REVIEW; VIREMIA; VIRUS LOAD;

ADULT; B-LYMPHOCYTES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HIV INFECTIONS; HUMANS; IMMUNOCOMPROMISED HOST; LYMPHOMA, AIDS-RELATED; MALE; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME;

EID: 33644758578     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (23)

1. Goedert JJ, Cote TR, Virgo P, Scoppa SM, et al (1998) Spectrum of AIDS-associated malignant disorders. Lancet 351:1833-1839
2. Clarke CA, Glaser SL (2001) Epidemiologic trends in HIV-associated lymphomas. Curr Opin Oncol 13:354-359
3. International Collaboration on HIV and Cancer (2000) Highly active antiretroviral therapy and incidence of cancer in human immunodeficiency virus-infected adults. J Natl Cancer Inst 92:1823-1830
4. Kirk O, Pedersen C, Cozzi-Lepri A et al (2001) Non-Hodgkin lymphoma in HIV-infected patients in the era of highly active antiretroviral therapy. Blood 98:3406-3412
5. Moses A, Nelson J, Bagby GC Jr (1998) The influence of human immunodeficiency virus-1 on hematopoiesis. Blood 91:1479-95
6. Kaplan LD, Straus DJ, Testa MA, et al (1997) Low-dose compared with standard-dose m-BACOD chemotherapy for non-Hodgkin's lymphoma associated with human immunodeficiency virus infection. N Engl J Med 336:1641-1648
7. Levine AM, Seneviratne L, Espina EM, et al (2000) Evolving characteristics of AIDS-related lymphoma. Blood 96: 4084-4090
8. Tirelli U, Spina M, Vaccher E, et al (1995) Clinical evaluation of 451 patients with HIV related non-Hodgkin's lymphoma: experience on the Italian cooperative group on AIDS and tumors (GICAT). Leuk Lymphoma 20:91-6
9. Antinori A, Cingolani A, Alba L, et al (2001) Better response to chemotherapy and prolonged survival in AIDS-related lymphomas responding to highly active antiretroviral therapy. AIDS 15:1483-1491
10. Hoffmann C, Wolf E, Fatkenheuer G, et al (2003) Response to highly active antiretroviral therapy strongly predicts outcome in patients with AIDS-related lymphoma. AIDS 17:1521-1529
11. Ratner L, Lee J, Tang S, et al (2001) Chemotherapy for human immunodeficiency virus-associated non-Hodgkin's lymphoma in combination with highly active antiretroviral therapy. J Clin Oncol 19:2171-2178
12. Powles T, Imami N, Nelson M, Gazzard BG, Bower M (2002) Effects of combination chemotherapy and highly active antiretroviral therapy on immune parameters in HIV-1 associated lymphoma. AIDS 16:531-536
13. Gratwohl A, Baldomero H, Passweg J, et al (2003) Hematopoietic stem cell transplantation for hematological malignancies in Europe. Leukemia 17:941-59
14. Gabarre J, Azar N, Autran B, Kadama C, Leblond V (2000) High-dose therapy and autologous haematopoietic stem-cell transplantation for HIV-1-associated lymphoma. Lancet 355:1071-1072
15. Gabarre J, Marcelin AG, Azar N, et al (2004) High-dose therapy plus autologous hematopoietic stem cell transplantation for human immunodeficiency virus (HIV)-related lymphoma: results and impact on HIV disease. Haematologica 89:1100-8
16. Re A, Cattaneo C, Michieli M, et al (2003) High-dose therapy and autologous peripheral-blood stem-cell transplantation as salvage treatment for HIV-associated lymphoma in patients receiving highly active antiretroviral therapy. J Clin Oncol 21:4423-7
17. Re A, Cattaneo C, Michieli MG, et al (2004) Ann Arbor stage is the most important predictor of survival for refractory and relapsed HIV-associated lymphoma enrolled in a program of high dose therapy and autologous peripheral blood stem cell transplantation. Abstract 893. 46th ASH Annual Meeting 2004, San Diego, USA
18. Krishnan A, Molina A, Zaia J, et al (2005) Durable remissions with autologous stem cell transplantation for high-risk HIV-associated lymphomas. Blood 105:874-878
19. Serrano D, Carrion R, Balsalobre P, et al (2005) HIV-associated lymphoma successfully treated with peripheral blood stem cell transplantation. Exp Hematol 33:487-94
20. Scadden DT (2004) Autologous stem cell transplantation for AIDS-related lymphomas: AIDS Malignancy Consortium 020. Abstract S15, 8th International Conference on Malignancies in AIDS and Other Immunodeficiencies 2004, Bethesda, Maryland, USA.
21. Campbell P, Iland H, Gibson J, Joshua D (1999) Syngeneic stem cell transplantation for HIV-related lymphoma. Br J Haematol 105:795-8
22. Kang EM, de Witte M, Malech H, et al (2002) Nonmyeloablative conditioning followed by transplantation of genetically modified HLA-matched peripheral blood progenitor cells for hematologic malignancies in patients with acquired immunodeficiency syndrome. Blood 99:698-701
23. Schooley RT, Mladenovic J, Sevin A, et al (2000) Reduced mobilization of CD34+ stem cells in advanced human immunodeficiency virus type 1 disease. J Infect Dis 181:148-57