Risk of colorectal cancer in monoallelic and biallelic carriers of MYH mutations: A population-based case-family study

Cancer Epidemiology Biomarkers and Prevention

Volumn 15, Issue 2, 2006, Pages 312-314

  Jenkins, Mark A ^a   Croitoru, Marina E ^b   Monga, Neerav ^d   Cleary, Sean P ^b   Cotterchio, Michelle ^d   Hopper, John L ^a   Gallinger, Steven ^c,d  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MOUNT SINAI HOSPITAL   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

^d CANCER CARE ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALLELE; ARTICLE; BIALLELE; CANCER RISK; COLORECTAL CANCER; CONFIDENCE INTERVAL; GENE MUTATION; GENE SEGREGATION; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MONOALLELE; MYH GENE; ONCOGENE; POPULATION BASED CASE CONTROL STUDY; PREDICTION; PRIORITY JOURNAL;

ADULT; AGED; ALLELES; COHORT STUDIES; COLORECTAL NEOPLASMS; DNA REPAIR; GERM-LINE MUTATION; HUMANS; MIDDLE AGED; MUTATION; MYOSIN HEAVY CHAINS; RISK ASSESSMENT;

EID: 33644747476     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-05-0793     Document Type: Article

References (19)

1. Al-Tassan N, Chmiel NH, Maynard J, et al. Inherited variants of MYH associated with somatic G:C>T:A mutations in colorectal tumors. Nat Genet 2002;30:227-32.
2. Sieber OM, Lipton L, Crabtree M, et al. Multiple colorectal adenomas, classical adenomatous polyposis and germ-line mutations in MYH. N Engl J Med 2003;348:791-9.
3. Croitoru M, Cleary S, Di Nicola N, et al. Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk. J Nat Cancer Inst 2004;96:1631-4.
4. Enholm S, Hienonen T, Suomalainen A, et al. Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients. Am J Pathol 2003;163:827-32.
5. Fleischmann C, Peto J, Cheadle J, Shah B, Sampson J, Houlston RS. Comprehensive analysis of the contribution of germline MYH variation to early-onset colorectal cancer. Int J Cancer 2004;109:554-8.
6. Kambara T, Whitehall VLJ, Spring KJ, et al. Role of inherited defects of MYH in the development of sporadic colorectal cancer. Genes Chromosomes Cancer 2004;40:1-9.
7. Wang L, Baudhuin LM, Boardman LA, et al. MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polyps. Gastroenterology 2004;127:9-16.
8. Peterlongo P, Mitra N, Chuai S, et al. Colorectal cancer risk in individuals with biallelic or monoallelic mutations of MYH. Int J Cancer 2005;114:505-7.
9. Farrington SM, Tenesa A, Barnetson R, et al. Germline susceptibility to colorectal cancer due to base-excision repair gene defects. Am J Hum Genet 2005;77:112-9.
10. Cotterchio M, McKeown-Eyssen G, Sutherland H, et al. Ontario Familial Colon Cancer Registry: methods and first-year response rates. Chronic Dis Can 2000;21:81-6.
11. Vasen HF, Watson P, Mecklin JP, Lynch HT. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 1999;116:1453-6.
12. StataCorp. Stata statistical software: release 8.0. College Station (TX): Stata Corporation; 2003.
13. Lange K, Boehnke M, Weeks D. Programs for pedigree analysis. Los Angeles: Department of Biomathematics, University of California at Los Angeles; 1987.
14. Hopper JL, Southey MC, Dite GS, et al. Population-based estimate of the average age-specific cumulative risk of breast cancer for a defined set of protein-truncating mutations in BRCA1 and BRCA2. Australian Breast Cancer Family Study. Cancer Epidemiol Biomarkers Prev 1999;8:741-7.
15. Antoniou A, Pharoah PD, Narod S, et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 2003;72:1117-30.
16. Johns LE, Houlston RS. A systematic review and meta-analysis of familial prostate cancer risk. BJU Int 2003;91:789-94.
17. Baglietto L, Jenkins MA, Severi G, et al. Two measures of familial aggregation from case-control and cohort studies: the example of colorectal cancer. J Clin Epidemiol. In press 2005.
18. White H. A heteroskedasticity-consistent covariance matrix estimator and a direct test for heteroskedasticity. Econometrica 1980;48:817-30.
19. Hopper JL, Bishop DT, Easton DF. Population-based family studies in genetic epidemiology. Lancet 2005;366:1397-406.