Membrane transporters in drug discovery and development: A new mechanistic ADME era

Molecular Pharmaceutics

Volumn 3, Issue 1, 2006, Pages 1-2

  Ware, Joseph A ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; CARRIER PROTEIN; GLYCOPROTEIN P; MEMBRANE TRANSPORTER; UNCLASSIFIED DRUG;

CELL STRAIN CACO 2; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG RESEARCH; DRUG TRANSPORT; EDITORIAL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

CACO-2 CELLS; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HUMANS; MEMBRANE TRANSPORT PROTEINS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33644698486     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp058084b     Document Type: Editorial

References (2)

1. Juliano, R. L.; Ling, V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim. Biophys. Acta 1976, 455, 152-62.
2. Schinkel, A. H.; Smit, J. J.; van Tellingen, O.; Beijnen, J. H.; Wagenaar, E.; van Deemter, L.; Mol, C. A.; van der Valk, M. A.; Robanus-Maandag, E. C.; te Riele, H. P.; et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 1994, 77, 491-502.