Inducers and inhibitors of biomineralization: Lessons from pathological calcification

Orthodontics and Craniofacial Research

Volumn 8, Issue 4, 2005, Pages 229-231

  Giachelli, Cecilia M ^a  

^a University of Washington   (United States)

Author keywords

Osteopontin; Phosphate; Sodiumdependent phosphate cotransporter; Vascular calcification

Indexed keywords

OSTEOPONTIN; PHOSPHATE; SIALOGLYCOPROTEIN; SODIUM PHOSPHATE COTRANSPORTER 3; SPP1 PROTEIN, HUMAN;

ANIMAL; ATHEROSCLEROSIS; BONE MINERALIZATION; CALCINOSIS; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMALS; ATHEROSCLEROSIS; CALCIFICATION, PHYSIOLOGIC; CALCINOSIS; HUMANS; OSTEOPONTIN; PHOSPHATES; SIALOGLYCOPROTEINS; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE III;

EID: 33644695343     PISSN: 16016335     EISSN: 16016343     Source Type: Journal    
DOI: 10.1111/j.1601-6343.2005.00345.x     Document Type: Review

References (10)

1. Speer MY, Giachelli CM. Regulation of cardiovascular calcification. Cardiovasc Pathol 2004;13:63-70.
2. Wada T, McKee MD, Stietz S, Giachelli CM. Calcification of vascular smooth muscle cell cultures: inhibition by osteopontin. Circ Res 1999;84:1-6.
3. Jono S, McKee MD, Murry CE, Shioi A, Nishizawa Y, Mori K et al. Phosphate regulation of vascular smooth muscle cell calcification. Circ Res 2000;87:E10-7.
4. Giachelli CM, Bae N, Almeida M, Denhardt DT, Alpers CE, Schwartz SM. Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques. J Clin Invest 1993;92:1686-96.
5. Jono S, Peinado C, Giachelli CM. Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification. J Biol Chem 2000;275:20197-203.
6. Steitz SA, Speer MY, Curinga G, Yang HY, Haynes P, Aebersold R et al. Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ Res 2001;89:1147-54.
7. Speer MY, McKee MD, Guldberg RE, Liaw L, Yang HY, Tung E et al. Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. J Exp Med 2002;196:1047-55.
8. Steitz SA, Speer MY, McKee MD, Liaw L, Almeida M, Yang H et al. Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Am J Pathol 2002;161:2035-46.
9. Beck GR Jr, Knecht N. Osteopontin regulation by inorganic phosphate is ERK1/2-, protein kinase C-, and proteasomedependent. J Biol Chem 2003;278:41921-9.
10. Beck GR Jr, Zerler B, Moran E. Phosphate is a specific signal for induction of osteopontin gene expression. Proc Natl Acad Sci USA 2000;97:8352-7.