Second-trimester prediction of severe placental complications in women with combined elevations in alpha-fetoprotein and human chorionic gonadotrophin

American Journal of Obstetrics and Gynecology

Volumn 194, Issue 3, 2006, Pages 821-827

  Alkazaleh, Fawaz ^a   Chaddha, Vandana ^a   Viero, Sandra ^a   Malik, Aasim ^a   Anastasiades, Colleen ^a   Sroka, Hana ^a   Chitayat, David ^a   Toi, Ants ^a   Windrim, Rory C ^a   Kingdom, John C ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Alpha fetoprotein; Human chorionic gonadotropin; Maternal serum screening; Placental dysfunction; Ultrasound

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA FETOPROTEIN; ALPHA TOCOPHEROL; ASCORBIC ACID; BETAMETHASONE; CHORIONIC GONADOTROPIN;

ADULT; CONFERENCE PAPER; DOPPLER FLOWMETRY; FEMALE; FETUS DEATH; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; ISCHEMIA; MAJOR CLINICAL STUDY; MATERNAL SERUM; PLACENTA DISORDER; PREGNANCY COMPLICATION; PREGNANCY DISORDER; PREMATURE LABOR; PRENATAL GROWTH; PRIORITY JOURNAL; PROSPECTIVE STUDY; SECOND TRIMESTER PREGNANCY; THROMBOSIS; UTERINE ARTERY; UTERUS MALFORMATION;

ADULT; ALPHA-FETOPROTEINS; CHORIONIC GONADOTROPIN; FEMALE; HUMANS; PLACENTA DISEASES; PREDICTIVE VALUE OF TESTS; PREGNANCY; PREGNANCY TRIMESTER, SECOND; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; ULTRASONOGRAPHY, DOPPLER; UTERUS;

EID: 33644694443     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2005.09.010     Document Type: Conference Paper

References (25)

1. J. Rankin, S. Glinianaia, R. Brown, and M. Renwick The changing prevalence of neural tube defects: a population-based study in the north of England, 1984-96. Northern Congenital Abnormality Survey Steering Group Paediatr Perinat Epidemiol 14 2000 104 110
2. B. Khoshnood, C. De Vigan, V. Vodovar, J. Goujard, and F. Goffinet A population-based evaluation of the impact of antenatal screening for Down's syndrome in France, 1981-2000 BJOG 111 2004 485 490
3. D.K. Waller, L.S. Lustig, G.C. Cunningham, M.S. Golbus, and E.B. Hook Second-trimester maternal serum alpha-fetoprotein levels and the risk of subsequent fetal death N Engl J Med 325 1991 6 10
4. N. Lepage, D. Chitayat, J. Kingdom, and T. Huang Association between second-trimester isolated high maternal serum maternal serum human chorionic gonadotropin levels and obstetric complications in singleton and twin pregnancies Am J Obstet Gynecol 188 2003 1354 1359
5. D. Chitayat, S.A. Farrell, T. Huang, C. Meier, P.R. Wyatt, and A.M. Summers Double-positive maternal serum screening results for down syndrome and open neural tube defects: an indicator for fetal structural or chromosomal abnormalities and adverse obstetric outcomes Am J Obstet Gynecol 187 2002 758 763
6. L. Dugoff, J.C. Hobbins, F.D. Malone, J. Vidaver, L. Sullivan, J.A. Canick for the FASTER Trial Research Consortium Quad screen as a predictor of adverse pregnancy outcome Obstet Gynecol 106 2005 260 267
7. T. Huang, T. Owolabi, A.M. Summers, C. Meier, and P.R. Wyatt The identification of risk of spontaneous fetal loss through second-trimester maternal serum screening Am J Obstet Gynecol 193 2005 395 403
8. S. Viero, V. Chaddha, F. Alkazaleh, M.J. Simchen, A. Malik, and E. Kelly Prognostic value of placental ultrasound in pregnancies complicated by absent end-diastolic flow velocity in the umbilical arteries Placenta 25 2004 735 741
9. P.S. Konchak, I.M. Bernstein, and E.L. Capeless Uterine artery Doppler velocimetry in the detection of adverse obstetric outcomes in women with unexplained elevated maternal serum alpha-fetoprotein levels Am J Obstet Gynecol 173 1995 1115 1119
10. B. Bromley, F.D. Frigoletto Jr., B.L. Harlow, S. Pauker, and B.R. Benacerraf The role of Doppler velocimetry in the structurally normal second-trimester fetus with elevated levels of maternal serum alpha-fetoprotein Ultrasound Obstet Gynecol 4 1994 377 380
11. M. Palacio, E. Jauniaux, J. Kingdom, E. Dell, A. Sheldrake, and C.H. Rodeck Perinatal outcome in pregnancies with a positive serum screening for Down's syndrome due to elevated levels of free beta-human chorionic gonadotropin Ultrasound Obstet Gynecol 13 1999 58 62
12. E. Jauniaux, G. Moscoso, S. Campbell, D. Gibb, M. Driver, and K.H. Nicolaides Correlation of ultrasound and pathologic findings of placental anomalies in pregnancies with elevated maternal serum alpha-fetoprotein Eur J Obstet Gynecol Reprod Biol 37 1990 219 230
13. M.A. Williams, D.E. Hickok, R.W. Zingheim, D.A. Luthy, J. Kimelman, and D.A. Nyberg Elevated maternal serum alpha-fetoprotein levels and midtrimester placental abnormalities in relation to subsequent adverse pregnancy outcomes Am J Obstet Gynecol 167 1992 1032 1037
14. F. Alkazaleh, S. Viero, M. Walker, M. Walker, G. Smith, and C. Laskin Ultrasound diagnosis of severe thrombotic placental damage in the second trimester Ultrasound Obstet Gynecol 23 2004 472 476
15. G. Albaiges, H. Missfelder-Lobos, C. Lees, M. Parra, and K.H. Nicolaides One-stage screening for pregnancy complications by color Doppler assessment of the uterine arteries at 23 weeks' gestation Obstet Gynecol 96 2000 559 564
16. L. Duley, D.J. Henderson-Smart, M. Knight, and J.F. King Antiplatelet agents for preventing pre-eclampsia and its complications Cochrane Database Syst Rev 2004 (1):CD004659
17. L.C. Chappell, P.T. Seed, A.L. Briley, F.J. Kelly, R. Lee, and B.J. Hunt Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial Lancet 354 1999 810 816
18. M.J. Simchen, F. Alkazaleh, S.L. Adamson, R. Windrim, J. Telford, and J. Beyene The fetal cardiovascular response to antenatal steroids in severe early-onset intrauterine growth restriction Am J Obstet Gynecol 190 2004 296 304
19. ACOG technical bulletin Hypertension in pregnancy. Number 219-January 1996 (replaces no 91, February 1986). Committee on Technical Bulletins of the American College of Obstetricians and Gynecologists Int J Gynaecol Obstet 53 1996 175 183
20. B. Huppertz, and J.C.P. Kingdom Apoptosis in the trophoblast - role of apoptosis in placental morphogenesis J Soc Gyn Invest 11 2004 353 362
21. F. Reister, H.G. Frank, J.C. Kingdom, W. Heyl, P. Kaufmann, and W. Rath Macrophage-induced apoptosis limits endovascular trophoblast invasion in the uterine wall of preeclamptic women Lab Invest 81 2001 1143 1152
22. G.C. Smith, J.A. Crossley, D.A. Aitken, J.P. Pell, A.D. Cameron, and J.M. Connor First-trimester placentation and the risk of antepartum stillbirth JAMA 292 2004 2249 2254
23. C.K. Yu, A.T. Papageorghiou, M. Parra, D.R. Palma, and K.H. Nicolaides Randomized controlled trial using low-dose aspirin in the prevention of pre-eclampsia in women with abnormal uterine artery Doppler at 23 weeks' gestation Ultrasound Obstet Gynecol 22 2003 233 239
24. J.C. Gris, E. Mercier, I. Quere, G. Lavigne-Lissalde, E. Cochery-Nouvellon, and M. Hoffet Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder Blood 103 2004 3695 3699
25. F. Audibert, Y. Benchimol, C. Benattar, C. Champagne, and R. Frydman Prediction of preeclampsia or intrauterine growth restriction by second trimester serum screening and uterine Doppler velocimetry Fetal Diagn Ther 20 2005 48 53