Anti-tumour effects of triple therapy with octreotide, galanin and serotonin in comparison with those of 5-fluorouracil/leukovorin on human colon cancer

International Journal of Oncology

Volumn 27, Issue 2, 2005, Pages 427-432

  Tjomsland, Veronica ^a   El Salhy, Magdy ^a  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

5 fluorouracil; Adenocarcinoma; Colon; Galanin; Leukovorin; Octreotide; Serotonin

Indexed keywords

ANTINEOPLASTIC AGENT; CD31 ANTIGEN; EPIDERMAL GROWTH FACTOR; FLUOROURACIL; FOLINIC ACID; GALANIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OCTREOTIDE; SEROTONIN; VASCULOTROPIN A;

ANIMAL; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL PROLIFERATION; COLON TUMOR; COMPARATIVE STUDY; DRUG EFFECT; DRUG SCREENING; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NICK END LABELING; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTIGENS, CD31; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BODY WEIGHT; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; EPIDERMAL GROWTH FACTOR; FLUOROURACIL; GALANIN; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LEUCOVORIN; MICE; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; OCTREOTIDE; POLY(ADP-RIBOSE) POLYMERASES; SEROTONIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 33644677527     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.27.2.427     Document Type: Article

References (24)

1. Parkin DM. Bray FI and Devesa SS: Cancer burden in the year 2000. The global picture. Eur J Cancer 37: 4-66. 2001.
2. Simmondx PC: Palliative chemotherapy for advanced colorectal cancer: systematic review and meta-analysis. Colorectal cancer Collaborative Group. BMJ 321: 531-535.'2(KK).
3. Primrose JN: Treatment of colorectal metastases: surgery, cryo-therapy, or radio frequency ablation. Gut 50: 1-5. 2002.
4. Van Laarhoven II and Puni C: Systemic treatment of advanced colorectal carcinoma: Eur J Gastroenirol Hepatol 16: 283-289. 2004.
5. O'Connel MJ: Current status of adjuvant therapy for colorectal cancer. Oncol 18; 751-758. 2004.
6. Ducreux M and Boige V: Adjuvant chemotherapy for colon cancer. Best Pract Res Clin Gastroenterol 16: 283-298. 2002.
7. Nicum S. Midglev R and Kerr DJ: Colorectal cancer. Acta Oncol 42: 263-275. 2003.
8. X. Sobrcro A. Kerr D. Glimelius B. Van Cutscm E. Milano G. Pritchard DM. Rougicr P and Aapro M: New directions in the treatment of colorectal cancer: a look to the future. Eur J Cancer 36: 559-566. 2000
9. Michael M and Zalchberg JR: Chemotherapy for advanced colorectal cancer. BMJ 321: 521-522. 2000.
10. Van Cutscm E. Verslype C and Demedts I: The treatment of advanced colorectal cancer: where are we now and where do we go? Best Pract Res Clin Gastroenterol 16: 319-330, 2(XX).
11. Diaz-Rubio E: New chemotherapeutic advances in pancreatic, colorectal, and gastric cancers. Oncologist 9: 2X2-294. 2004.
12. Goldberg RM: Current approaches to list-line treatment of advanced colorectal cancer. Clin Colorectal Cancer I: 9-15 2004.
13. Penland SK and Goldberg RM: Current strategies in previously untreted colorectal cancer. Oncology 18: 715-722. 2004.
14. El-Sahly M and Sitohy B: Triple therapy with octreotide, galanin and serotonin induces necrosis and increases apoptosis of a rat colon carcinoma. Regul Pept 108: 55-62. 2002.
15. El-Salhy M. Sitohy B and Norrgärd 6: Triple therapy with octreotide, galanin. and serotonin reduces the size and blood vessel density and increases apoptosis of a rat colon carcinoma. Regul Pept III: 145-152. 2003.
16. Sitohy B and El-Salhy M: A comparison between double and triple therapies of octreotide, galanin and serotonin on a rat colon carcinoma. Histol Histopathol 18: 103-110.2003.
17. El-Salhy M and Dennerqvist V: Effects of triple therapy with octreotide, galanin and serotonin on liver metastasis of human colon cancer in xenografts. Oncol Rep II: 1177-1182. 2004.
18. El-shalhy M: Comparison between triple therapy with octreotide, galanin and serotonin. 5-Huorouracil/leukovorin. and sequential treatment with both, on human colon cancer. Oncol Rep 11: 1161-1168. 2004.
19. El-Salhy M and Starefeldt A: The direct effects of octreotide, galanin and serotonin on human colon cancer cells. Oncol Rep 10: 1723-1728. 2003.
20. Kerr J. Wexlor R. Mousa S. Robinson C. Wexler E. Mohamed S. Voss M. Devenny J. Czermiak A Jr and Slee A: Novel small moleculr of alpha γ. Integrin antagonists:comperative anticancer efficacy with known angiogenesis inhibitors. Anticancer Res 19: 959-956. 1999.
21. Midgely OR and Kerr D: Colorectal cancer. Lancet 353: 391-399. 1999.
22. Heath KJ: Principles of Cell Proliferation. Blackwell Science Ltd.. Oxford. 2001.
23. Chao CJJ. Peng LW and Chen HS: Effects of epidermal growth factor and its signal transduction inhibitors on apoptosis in human colorectal cancer cells. World J Gastroenterol 10: 540-544. 2004.
24. Cuba M. Seelinger H. Kleespies A. Jauch WK and Bruns C: Vascular endothelial growth factor in colorectal cancer. Int J Colorectal Dis 19: 510-517. 2004.