Tiagabine increases slow-wave sleep in a dose-dependent fashion without affecting traditional efficacy measures in adults with primary insomnia

Journal of Clinical Sleep Medicine

Volumn 2, Issue 1, 2006, Pages 35-41

  Walsh, James K ^a,g   Perils, Michael ^b   Rosenthal, Murray ^c   Krystal, Andrew ^d   Jiang, John ^e   Roth, Thomas ^f  

^a ST LUKE S HOSPITAL   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c BMR Healthquest   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e CEPHALON INC   (United States)

^f HENRY FORD HOSPITAL   (United States)

^g Sleep Medicine and Research Center   (United States)

Author keywords

Primary insomnia; Sleep disturbance; Slow wave sleep; Stage 3 and 4 sleep; Tiagabine

Indexed keywords

PLACEBO; TIAGABINE;

ADULT; ANXIETY DISORDER; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DAYTIME SOMNOLENCE; DIZZINESS; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HEADACHE; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MALE; NAUSEA; POLYSOMNOGRAPHY; PSYCHOMOTOR PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; SLEEP STAGE; SLEEP TIME; SLEEP WAKING CYCLE; SLOW WAVE SLEEP; SOMNOLENCE;

EID: 33644659911     PISSN: 15509389     EISSN: 15509397     Source Type: Journal    
DOI: 10.5664/jcsm.26433     Document Type: Article

References (19)

1. Roehrs T, Roth T. 'Hypnotic' prescription patterns in a large managed-care population. Sleep Med 2004;5:463-6.
2. Walsh JK, Schweitzer PK. Ten-year trends in the pharmacological treatment of insomnia. Sleep 1999;22:371-5.
3. Walsh JK. Drugs used to treat insomnia in 2002: regulatory-based rather than evidence-based medicine. Sleep 2004;27:1441-2.
4. Taylor FB. Tiagabine for posttraumatic stress disorder: a case series of 7 women. J Clin Psychiatry 2003;64:1421-5.
5. Rosenthal M. Tiagabine for the treatment of generalized anxiety disorder: A randomized, open-label, clinical trial with paroxetine as a positive control. J Clin Psychiatry 2003;64:1245-9.
6. Borden LA, Murali Dhar TG, Smith KE, et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol 1994;269:219-24.
7. Fink-Jensen A, Suzdak PD, Swedberg M.D., et al. The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats. Eur J Pharmacol 1992;220:197-201.
8. Mathias S, Wetter TC, Steiger A, Lancel M. The GABA uptake inhibitor tiagabine promotes slow wave sleep in normal elderly subjects. Neurobiol Aging 2001;22:247-53.
9. Walsh JK, Zammit GK, Schweitzer PK, Ondrasik J, Roth T. Tiagabine enhances slow wave sleep and sleep maintenance in primary insomnia. Sleep Med 2005:[epub ahead of print].
10. Walsh JK, Randazzo AC, Frankowski S, Shannon K, Schweitzer PK, Roth T. Dose-response effects of tiagabine on the sleep of older adults. Sleep 2005;28:673-6.
11. th ed. Washington: American Psychiatric Association; 2000.
12. nd ed. Philadelphia: W.B. Saunders Company; 1994:943-60.
13. Rechtschaffen A, Kales A. A manual of standardized terminology, techniques and scoring system for sleep stages in human subjects. Washington: US Government Printing Office; 1968.
14. Stone BM. Pencil and paper tests-sensitivity to psychotropic drugs. Br J Clin Pharmacol 1984;18 Suppl 1:15S-20S.
15. Roehrs T, Bonahoom A, Pedrosi B, Rosenthal L, Roth T. Disturbed sleep predicts hypnotic self-administration. Sleep Med 2002;3:61-6.
16. Northrop Grumman Corporation. Medical Dictionary for Regulatory Activities; 2004. Available at http://www.meddramsso.com/New-Web2003/ meddra_overview/index.htm; Accessed July 16, 2005.
17. GABITRIL [package insert]. Frazer, PA: Cephalon, Inc.; 2005.
18. Ambrosini MV, Giuditta A. Learning and sleep: the sequential hypothesis. Sleep Med Rev 2001;5:477-90.
19. Edinger JD, Glenn DM, Bastian LA, Marsh GR. Slow-wave sleep and waking cognitive performance II: Findings among middle-aged adults with and without insomnia complaints. Physiol Behav 2000;70:127-34.