MIB-1 and MCM-2 immunohistochemical analysis does not aid in identification of serrated colorectal polyps with abnormal proliferation

American Journal of Clinical Pathology

Volumn 125, Issue 3, 2006, Pages 407-412

  Gray, David ^a   Obermann, Ellen C ^b   Evans, Mark ^a   Hartmann, Arndt ^b   Cooper, Kumarasen ^a   Blaszyk, Hagen ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Hyperplastic polyp; MCM 2; MIB 1; Serrated neoplasia pathway; Serrated polyp

Indexed keywords

EOSIN; HEMATOXYLIN; KI 67 ANTIGEN; MINICHROMOSOME MAINTENANCE PROTEIN 2;

ARTICLE; CELL PROLIFERATION; COLON BIOPSY; COLON POLYP; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE CRYPT; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SERRATED POLYP WITH ABNORMAL PROLIFERATION; TRANSVERSE COLON;

EID: 33644648198     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/E1BG63G8XAW32DNE     Document Type: Article

References (12)

1. Rashid A, Houlihan PS, Booker S, et al. Phenotypic and molecular characteristics of hyperplastic polyposis. Gastroenterology. 2000;119:323-332.
2. Hawkins NJ, Gorman P, Tomlinson NJ, et al. Colorectal carcinomas arising in the hyperplastic polyposis syndrome progress through the chromosomal instability pathway. Am J Pathol. 2000;157:385-392.
3. Jass JR, Iino H, Ruszkiewicz A, et al. Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. Gut. 2000;47:43-49.
4. Snover DC, Jass JR, Fenoglio-Preiser C, et al. Serrated polyps of the large intestine. Am J Clin Pathol. 2005;124:773-775.
5. Goldstein NS, Bhanot P, Odish E, et al. Hyperplastic-like colon polyps that preceded microsatellite unstable adenocarcinomas. Am J Clin Pathol. 2003;119:778-796.
6. Torlakovic E, Skovlund E, Snover DC, et al. Morphologic reappraisal of serrated colorectal polyps. Am J Surg Pathol. 2003;27:65-81.
7. O'Brien MJ, Yang S, Clebanoff JL, et al. Hyperplastic (serrated) polyps of the colorectum: relationship of CpG island methylator phenotype and k-ras mutation to location and histologic subtype. Am J Surg Pathol. 2004;28:423-434.
8. Jass JR. Hyperplastic polyps and colorectal cancer: is there a link? Clin Gastroenterol Hepatol. 2004;2:1-8.
9. Huang CS, O'Brien MJ, Yang S, et al. Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway. Am J Gastroenterol. 2004;99:2242-2255.
10. Coard KC, Freeman VL. Gleason grading of prostate cancer: level of concordance between pathologists at the University Hospital of the West Indies. Am J Clin Pathol. 2004;122:272-376.
11. Kang M, Mitoni H, Sada M, et al. Ki-67, p53, and bcl-2 expression of serrated adenomas of the colon. Am J Surg Pathol. 1997;21:417-423.
12. Lazarus R, Junttila OE, Karttunen TJ, et al. The risk of metachronous neoplasia in patients with serrated adenoma. Am J Clin Pathol. 2005;123:349-359.