High performance liquid chromatographic determination of ginkgotoxin and ginkgotoxin-5′-glucoside in Ginkgo biloba seeds

Journal of Liquid Chromatography and Related Technologies

Volumn 29, Issue 4, 2006, Pages 605-616

  Yoshimura, Teruki ^a   Udaka, Nobuyoshi ^a   Morita, Junsuke ^a   Jinyu, Zhang ^a   Sasaki, Keiko ^a   Kobayashi, Daisuke ^a   Wada, Keiji ^a   Hori, Yasushi ^b  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^b NIIGATA CITY GENERAL HOSPITAL   (Japan)

Author keywords

Fluorescence detection; Ginkgo biloba seeds; Ginkgotoxin; Ginkgotoxin 5 glucoside; HPLC

Indexed keywords

FLUORESCENCE; SEPARATION; TOXIC MATERIALS; VITAMINS;

FLUORESCENCE DETECTION; GINKGO BILOBA SEEDS; GINKGOTOXIN; GINKGOTOXIN-5′-GLUCOSIDE;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

4' O METHYLPYRIDOXIN; GINKGO BILOBA EXTRACT; GINKGOTOXIN 5' GLUCOSIDE; GLUCOSIDE; PYRIDOXINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CALIBRATION; DRUG DETERMINATION; ELUTION; FLUORESCENCE; GINKGO BILOBA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PH MEASUREMENT; PLANT SEED; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE;

GINKGO BILOBA;

EID: 33644647132     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070500531466     Document Type: Article

References (12)

1. Wada, K.; Haga, M. Ginkgo Biloba - A Global Treasure; Springer-Verlag: Tokyo, Japan, 1997; 309.
2. Wada, K. Ginkgo Biloba. Medicinal and Aromatic Plants-Industrial Profiles; Harwood Academic Publishers: Amsterdam, The Netherlands, 2000; Vol. 12, 453.
3. 6, 4′-methoxypyridoxine from the seed of Ginkgo biloba L. Chem. Pharm. Bull. 1985, 33, 3555-3557.
4. Wada, K.; Ishigaki, S.; Ueda, K.; Take, Y.; Sakata, M.; Haga, M. Study on the constituents of edible and medicinal plants. I. Isolation and identification of 4-O-methylpyridoxine, toxic principle from the seed of Ginkgo biloba L. Chem. Pharm. Bull. 1988, 36, 1779-1782.
5. Scott, P.M.; Lau, B.P.-Y.; Lawrence, G.A.; Lewis, D.A. Analysis of Ginkgo biloba for the presence of ginkgotoxin and ginkgotoxin 5′-glucoside. J. AOAC Int. 2000, 83, 1313-1320.
6. Lawrence, G.A.; Scott, P.M. Improved extraction of ginkgotoxin (4′-O-methylpyridoxine) from Ginkgo biloba Products. J. AOAC Int. 2005, 88, 26-29.
7. Vanderslice, J.T.; Brownlec, S.G.; Cortissoz, M.E.; Maire, C.E. Modern Chromatographic Analysis of the Vitamins; Marcel Dekker: New York, 1985; Vol. 30, 436.
8. 6 vitamers and metabolites in a biological sample. Methods in Enzymol. 1997, 280, 3-12.
9. Yagi, M.; Wada, K.; Sakata, M.; Kokubo, M.; Haga, M. Studies on the constituents of edible and medicinal plants. IV. Determination of 4-O-methylpyridoxine in serum of the patient with Gin-nan food poisoning. Yakugaku Zasshi 1993, 113, 596-599.
10. 6. II. Reactions and derivatives. J. Am. Chem. Soc. 1940, 62, 3203-3205.
11. 6 and its identification as 5′-O-(β-D-glucopyranosyl)pyridoxine. Agric. Biol. Chem. 1977, 41, 1061-1067.
12. Bollenback, G.N.; Long, J.W.; Benjamin, D.G.; Lindquist, J.A. The synthesis of aryl-D-glucopyrano- siduronic acids. J. Am. Chem. Soc. 1955, 77, 3310-3315.