Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations

Molecular Psychiatry

Volumn 11, Issue 3, 2006, Pages 301-311

  Belfer, I ^a,b   Hipp, H ^a,b   McKnight, C ^a,b   Evans, C ^a,b   Buzas, B ^a,b   Bollettino, A ^a,b   Albaugh, B ^c   Virkkunen, M ^d   Yuan, Q ^b   Max, M B ^a   Goldman, D ^b   Enoch, M A ^b  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^c Center for Human Behavior Studies   (United States)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Alcoholism; Anxiety; Galanin; Haplotype; Linkage disequilibrium; Single nucleotide polymorphism

Indexed keywords

GALANIN;

ADULT; AFRICAN AMERICAN; ALCOHOLISM; ANXIETY DISORDER; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; ETHNIC DIFFERENCE; FEMALE; GENETIC ASSOCIATION; GENETIC RECOMBINATION; GENOTYPE; HAPLOTYPE; HUMAN; INDIAN; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; PERSONALITY TEST; PRIORITY JOURNAL; QUESTIONNAIRE; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; VULNERABLE POPULATION;

AFRICAN CONTINENTAL ANCESTRY GROUP; ALCOHOLISM; ANXIETY; BASE SEQUENCE; DNA PRIMERS; ETHNIC GROUPS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FINLAND; GALANIN; GENOTYPE; HARM REDUCTION; HUMANS; INDIANS, NORTH AMERICAN; MALE; QUESTIONNAIRES; UNITED STATES;

EID: 33644632419     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4001768     Document Type: Article

References (44)

1. Jacobowitz DM, Kresse A, Skofitsch G. Galanin in the brain: chemoarchitectonics and brain cartography - a historical review. Peptides 2004; 25: 433-464.
2. Wrenn CC, Crawley JN. Pharmacological evidence supporting a role for galanin in cognition and affect. Prog Neuropsychopharmacol Biol Psychiatry 2001; 25: 283-299.
3. Crawley JN. Biological actions of galanin. Regul Pept 1995; 59: 1-16.
4. Hokfelt T, Broberger C, Diez M, Xu ZQ, Shi T, Kopp J et al. Galanin and NPY, two peptides with multiple putative roles in the nervous system. Horm Metab Res 1999; 31: 330-334.
5. Yoshitake T, Wang FH, Kuteeva E, Holmberg K, Yamaguchi M, Crawley JN et al. Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test. Proc Natl Acad Sci USA 2004; 101: 354-359.
6. Yoshitake T, Reenila I, Ogren SO, Hokfelt T, Kehr J. Galanin attenuates basal and antidepressant drug-induced increase of extracellular serotonin and noradrenaline levels in the rat hippocampus. Neurosci Lett 2003; 339: 239-242.
7. Charney DS. Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. Am J Psychiatry 2004; 161: 195-216.
8. Hokfelt T, Xu ZQ, Shi TJ, Holmberg K, Zhang X. Galanin in ascending systems. Focus on coexistence with 5-hydroxytryptamine and noradrenaline. Ann NY Acad Sci 1998; 863: 252-263.
9. Ma X, Tong YG, Schmidt R, Brown W, Payza K, Hodzic L et al. Effects of galanin receptor agonists on locus coeruleus neurons. Brain Res 2001; 919: 169-174.
10. Sevcik J, Finta EP, Illes P. Galanin receptors inhibit the spontaneous firing of locus coeruleus neurones and interact with mu-opioid receptors. Eur J Pharmacol 1993; 230: 223-230.
11. Khoshbouei H, Cecchi M, Morilak DA. Modulatory effects of galanin in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress. Neuropsychopharmacology 2002; 27: 25-34.
12. Bing O, Moller C, Engel JA, Soderpalm B, Heilig M. Anxiolytic-like action of centrally administered galanin. Neurosci Lett 1993; 164: 17-20.
13. Holmes A, Yang RJ, Crawley JN. Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic mice. J Mol Neurosci 2002; 18: 151-165.
14. Kuteeva E, Hokfelt T, Ogren SO. Behavioural characterisation of young adult transgenic mice overexpressing galanin under the PDGF-B promoter. Regul Pept 2005; 125: 67-78.
15. Khoshbouei H, Cecchi M, Dove S, Javors M, Morilak DA. Behavioral reactivity to stress: amplification of stress-induced noradrenergic activation elicits a galanin-mediated anxiolytic effect in central amygdala. Pharmacol Biochem Behav 2002; 71: 407-417.
16. Brady KT, Sonne SC. The role of stress in alcohol use, alcoholism treatment, and relapse. Alcohol Res Health 1999; 23: 263-271.
17. Breese GR, Chu K, Dayas CV, Funk D, Knapp DJ, Koob GF et al. Stress enhancement of craving during sobriety: a risk for relapse. Alcohol Clin Exp Res 2005; 29: 185-195.
18. Rada P, Mark GP, Hoebel BG. Galanin in the hypothalamus raises dopamine and lowers acetylcholine release in the nucleus accumbens: a possible mechanism for hypothalamic initiation of feeding behavior. Brain Res 1998; 798: 1-6.
19. Leibowitz SF, Avena NM, Chang GQ, Karatayev O, Chau DT, Hoebel BG. Ethanol intake increases galanin mRNA in the hypothalamus and withdrawal decreases it. Physiol Behav 2003; 79: 103-111.
20. Lewis MJ, Johnson DF, Waldman D, Leibowitz SF, Hoebel BG. Galanin microinjection in the third ventricle increases voluntary ethanol intake. Alcohol Clin Exp Res 2004; 28: 1822-1828.
21. Rada P, Avena NM, Leibowitz SF, Hoebel BG. Ethanol intake is increased by injection of galanin in the paraventricular nucleus and reduced by a galanin antagonist. Alcohol 2004; 33: 91-97.
22. Thiele TE, Stewart RB, Badia-Elder NE, Geary N, Massi M, Leibowitz SF et al. Overlapping peptide control of alcohol self-administration and feeding. Alcohol Clin Exp Res 2004; 28: 288-294.
23. Evans H, Baumgartner M, Shine J, Herzog H. Genomic organization and localization of the gene encoding human preprogalanin. Genomics 1993; 18: 473-477.
24. Kofler B, Lapsys N, Furler SM, Klaus C, Shine J, Iismaa TP. A polymorphism in the 3′ region of the human preprogalanin gene. Mol Cell Probes 1998; 12: 431-432.
25. Eckenrode S, Marron MP, Nicholls R, Yang MC, Yang JJ, Guida Fonseca LC et al. Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses. Hum Genet 2000; 106: 14-18.
26. Vrontakis ME, Torsello A, Friesen HG. Galanin. J Endocrinol Invest 1991; 14: 785-794.
27. Association AP. Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association Press: Washington DC, revised, 1987.
28. Endicott J, Spitzer RL. A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 1978; 35: 837-844.
29. Skinner HA, Sheu WJ. Reliability of alcohol use indices. The Lifetime Drinking History and the MAST. J Stud Alcohol 1982; 43: 1157-1170.
30. Lappalainen J, Long JC, Eggert M, Ozaki N, Robin RW, Brown GL et al. Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. Arch Gen Psychiatry 1998; 55: 989-994.
31. Enoch MA, Albaugh B, Virkkunen M, Goldman D. Anxious temperament mediates linkage of GABRA2 haplotypes with alcoholism (submitted).
32. Spitzer RL, Williams JB, Gibbon M, First MB. The Structured Clinical Interview for DSM-III-R (SCID). I: history, rationale, and description. Arch Gen Psychiatry 1992; 49: 624-629.
33. Williams JB, Gibbon M, First MB, Spitzer RL, Davies M, Borus J et al. The Structured Clinical Interview for DSM-III-R (SCID). II. Multisite test-retest reliability. Arch Gen Psychiatry 1992; 49: 630-636.
34. Cloninger CR. A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry 1987; 44: 573-588.
35. Heath AC, Cloninger CR, Martin NG. Testing a model for the genetic structure of personality: a comparison of the personality systems of Cloninger and Eysenck. J Pers Soc Psychol 1994; 66: 762-775.
36. Shi MM, Myrand SP, Bleavins MR, de la Iglesia FA. High throughput genotyping for the detection of a single nucleotide polymorphism in NAD(P)H quinone oxidoreductase (DT diaphorase) using TaqMan probes. Mol Pathol 1999; 52: 295-299.
37. Mulligan CJ, Hunley K, Cole S, Long JC. Population genetics, history, and health patterns in native Americans. Annu Rev Genomics Hum Genet 2004; 5: 295-315.
38. Stephens M, Donnelly P. A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003; 73: 1162-1169.
39. Long JC, Williams RC, Urbanek M. An E-M algorithm and testing strategy for multiple-locus haplotypes. Am J Hum Genet 1995; 56: 799-810.
40. Clamp M, Cuff J, Searle SM, Barton GJ. The Jalview Java alignment editor. Bioinformatics 2004; 20: 426-427.
41. Ke X, Cardon LR. Efficient selective screening of haplotype tag SNPs. Bioinformatics 2003; 19: 287-288.
42. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B et al. The structure of haplotype blocks in the human genome. Science 2002; 296: 2225-2229.
43. Shen ES, Meade EH, Perez MC, Deecher DC, Negro-Vilar A, Lopez FJ. Expression of functional estrogen receptors and galanin messenger ribonucleic acid in immortalized luteinizing hormone-releasing hormone neurons: estrogenic control of galanin gene expression. Endocrinology 1998; 139: 939-948.
44. Ponchon M, Lause P, Maiter D. In vitro effects of oestradiol on galanin gene expression in rat anterior pituitary cells. J Neuroendocrinol 2000; 12: 559-564.