The dasyscyphins A∼C and niveulone, new biologically active compounds from the ascomycete Dasyscyphus niveus

Journal of Antibiotics

Volumn 59, Issue 1, 2006, Pages 53-56

  Mierau, Viktor ^a   Rojas De La Parra, Veronica ^b   Sterner, Olov ^b   Anke, Timm ^a  

^a Institute of Biotechnology and Drug Research   (Germany)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Cytotoxic activities; Dasyscyphins A C; Dasyscyphus niveus; Niveulone

Indexed keywords

DASYSCYPHIN; NIVEULONE; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTINEOPLASTIC ANTIBIOTIC; DASYSCYPHIN A; DASYSCYPHIN B; DASYSCYPHIN C; DITERPENE; DNA; RNA;

ANTIMICROBIAL ACTIVITY; ARTICLE; ASCOMYCETES; BIOLOGICAL ACTIVITY; CYTOTOXICITY; FERMENTATION MEDIUM; FUNGAL STRAIN; HUMAN; HUMAN CELL; PRIORITY JOURNAL; BACTERIUM; BIOSYNTHESIS; DRUG EFFECT; FERMENTATION; FUNGUS; ISOLATION AND PURIFICATION; LEUKEMIA CELL LINE; METABOLISM; MICROBIOLOGICAL EXAMINATION; YEAST;

ASCOMYCOTA; DASYSCYPHUS; FUNGI;

ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; ASCOMYCOTA; BACTERIA; DITERPENES; DNA, NEOPLASM; FERMENTATION; FUNGI; HUMANS; JURKAT CELLS; MICROBIAL SENSITIVITY TESTS; RNA, NEOPLASM; YEASTS;

EID: 33644555234     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2006.8     Document Type: Article

References (11)

1. Takahashi S, Hosoya T. New terpene compounds F-12436A, B, and C of Dasyscyphella nivea having antibacterial activity. JP 09176091 07.08 (1997)
2. Mierau V, Anke T, Sterner O. Two new biologically active cyclopentenones from Dasyscyphus sp. A47-98. J. Antibiot 57: 311-315 (2004)
3. Tanaka M, Nara F, Suzuki-Konagai K, Hosoya T, Ogita T. Structural elucidation of scyphostatin, an inhibitor of membrane-bound neutral sphingomyelinase. J Am Chem Soc 119: 7871-7872 (1997)
4. Rojas de la Parra V, Mierau V, Anke T, Sterner O. Niveulone, a heterocyclic spiro terpenoid from the ascomycete Dasyscyphus niveus. J. Antibiot, submitted
5. Rojas de la Parra V, Mierau V, Anke T, Sterner O. Cytotoxic terpenoids from Dasyscyphus niveus. Tetrahedron, in print
6. Anke H, Bergendorff O, Sterner O. Assays of the biological activities of guaiane sesquiterpenoids isolated from the fruit bodies of edible Lactarius species. Food Chem Toxicol 27: 393-397 (1989)
7. Filip P, Weber RWS, Sterner O, Anke T. Hormonemate, a new cytotoxic and apoptosis-inducing compound from the endophytic fungus Hormonema dematioides. I. Identification of the producing strain, and isolation and biological properties of hormonemate. Z Naturforsch 56c: 547-552 (2003)
8. Goclik E, Konig G M, Wright A D, Kaminsky R. Pelorol from the tropical marine sponge Dactylospongia elegans. J Nat Prod 63: 1150-1152 (2000)
9. Kwak JH, Schmitz FJ, Kelly M. Sesquiterpene quinols/quinones from the Micronesian sponge Petrosaspongia metachromia. J Nat Prod 63: 1153-1156 (2000)
10. Venkateswarlu Y, Faulkner DY. Smenochromenes, unusual macrocyclic sesquiterpene hydroquinone derivatives from a seychelles sponge of the genus Smenospongia. J Org Chem 56: 6271-6274 (1991)
11. Pendaries C, Tronchere H, Plantavid M, Payrastre B. Phosphoinositide signaling disorders in human diseases. FEBS Lett 546(1): 25-31 (2003)