Risk assessment of human myelotoxicity of anticancer drugs: A predictive model and the in vitro colony forming unit granulocyte/macrophage (CFU-GM) assay

Pharmazie

Volumn 61, Issue 2, 2006, Pages 135-139

  Masubuchi, Noriko ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; 9 AMINOCAMPTOTHECIN; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; EXATECAN; IRINOTECAN; TOPOTECAN;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BONE MARROW TOXICITY; COLONY FORMING UNIT GM; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IC 50; IN VITRO STUDY; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; RISK ASSESSMENT; TOXICOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AREA UNDER CURVE; BONE MARROW DISEASES; CAMPTOTHECIN; DATA INTERPRETATION, STATISTICAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MICE; NEUTROPENIA; PREDICTIVE VALUE OF TESTS; RISK ASSESSMENT; STEM CELLS; TUMOR STEM CELL ASSAY;

EID: 33644550695     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Bradley TR, Metcalf D (1966) The growth of mouse bone marrow cells in vitro. Aust J Exp Biol Med Sci 44: 287-300.
2. Erickson-Miller CL, May RD, Tomaszewski J, Osborn B, Murphy MJ, Page JG, Parchment RE (1997) Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro. Cancer Chemother Pharmacol 39: 467-472.
3. Masubuchi N, May RD, Atsumi R (2004) A predictive model of human myelotoxicity using five camptothecin derivatives and the in vitro colony-forming unit granulocyte/macrophage assay. Clin Cancer Res 10: 6722-6731.
4. Parchment RE, Gordon M, Grieshaber CK, Sessa C, Volpe D, Ghielmini M (1998) Predicting hematological toxicity (myelosuppression) of cytotoxic drug therapy from in vitro tests. Ann Oncol 9: 357-364.
5. Pessina A, Albella B, Bueren J, Brantom P, Casati S, Gribaldo L, Croera C, Gagliardi G, Foti P, Parchment R, Parent-Massin D, Sibiril Y, Van Den Heuvel R (2001) Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay. Toxicology In Vitro 15: 729-740.