Evaluation of BM-573, a novel TXA2 synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion

Prostaglandins and Other Lipid Mediators

Volumn 79, Issue 1-2, 2006, Pages 53-73

  Kolh, Philippe ^a,e   Rolin, Stéphanie ^b   Tchana Sato, Vincent ^a   Pétein, Michel ^c   Ghuysen, Alexandre ^a   Lambermont, Bernard ^a   Hanson, Julien ^a   Magis, David ^a   Segers, Patrick ^d   Masereel, Bernard ^b   D'Orio, Vincent ^a   Dogne, Jean Michel ^b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF NAMUR   (Belgium)

^c INSTITUTE OF PATHOLOGY AND GENETICS   (Belgium)

^d GHENT UNIVERSITY   (Belgium)

^e UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Contractile function; Hemodynamics; Myocardial ischemia; Pig; Reperfusion injury; Thromboxane receptor antagonist; Thromboxane synthase inhibitor

Indexed keywords

ARACHIDONIC ACID; BM 573; DESMIN; N TERT BUTYL N' [2 (4 METHYLPHENYLAMINO) 5 NITROBENZENESULFONYL]UREA; THROMBOXANE RECEPTOR BLOCKING AGENT; THROMBOXANE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ELECTRON MICROSCOPY; FEMALE; HEART AFTERLOAD; HEART EJECTION FRACTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; HEART OUTPUT; HEART PROTECTION; HEART STROKE VOLUME; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; REPERFUSION INJURY; SWINE; THROMBOCYTE AGGREGATION;

ANIMALS; BLOOD PRESSURE; CARDIAC OUTPUT; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; FEMALE; INFUSIONS, INTRAVENOUS; MALE; MYOCARDIAL REPERFUSION INJURY; RECEPTORS, THROMBOXANE; SULFONYLUREA COMPOUNDS; SWINE; THROMBOXANE-A SYNTHASE; VENTRICULAR FUNCTION, LEFT;

EID: 33644537934     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2005.10.002     Document Type: Article

References (52)

1. GISSI Investigators. Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI). Lancet 1986;1:397.
2. C.L. Grines, K.F. Browne, and J. Marco A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. The Primary Angioplasty in Myocardial Infarction Study Group N Engl J Med 328 1993 673
3. F. Zijlstra, M.J. de Boer, J.C. Hoorntje, S. Reiffers, J.H. Reiber, and H. Suryapranata A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction N Engl J Med 328 1993 680
4. GUSTO Investigators. An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. The GUSTO investigators. N Engl J Med 1993;329:673.
5. D.J. Hearse, S.M. Humphrey, W.G. Nayler, A. Slade, and D. Border Ultrastructural damage associated with reoxygenation of the anoxic myocardium J Mol Cell Cardiol. 7 1975 315
6. L.H. Opie Reperfusion injury and its pharmacologic modification Circulation 80 1989 1049
7. K.A. Reimer, M. Tanaka, C.E. Murry, V.J. Richard, and R.B. Jennings Evaluation of free radical injury in myocardium Toxicol Pathol 18 1990 470
8. Y. Haga, N. Hatori, M. Nordlander, R. Nordlander, P.O. Sjoquist, and L. Ryden Coronary venous retroinfusion of felodipine reducing infarct size without affecting regional myocardial blood flow Eur Heart J 14 1993 1386
9. N. Hatori, Y. Haga, P.O. Sjoquist, M. Nordlander, and L. Ryden Coronary venous retroinfusion of felodipine reduces myocardial necrosis after coronary occlusion and reperfusion J Cardiovasc Pharmacol 22 1993 160
10. Q.D. Wang, X.S. Li, J.M. Lundberg, and J. Pernow Protective effects of non-peptide endothelin receptor antagonist bosentan on myocardial ischaemic and reperfusion injury in the pig Cardiovasc Res 29 1995 805
11. D.J. Fitzgerald, L. Roy, F. Catella, and G.A. FitzGerald Platelet activation in unstable coronary disease N Engl J Med 315 1986 983
12. M. Tada, T. Kuzuya, S. Hoshida, and M. Nishida Arachidonate metabolism in myocardial ischemia and reperfusion J Mol Cell Cardiol 20 Suppl. 2 1988 135
13. M. Tanabe, Z.I. Terashita, and S. Fujiwara Coronary circulatory failure and thromboxane A2 release during coronary occlusion and reperfusion in anaesthetised dogs Cardiovasc Res 16 1982 99
14. T. Kuzuya, S. Hoshida, M. Nishida, Y. Kim, T. Kamada, and M. Tada Increased production of arachidonate metabolites in an occlusion-reperfusion model of canine myocardial infarction Cardiovasc Res 21 1987 551
15. K. Higo, J. Sano, A. Karasawa, and K. Kubo The novel thromboxane A2 receptor antagonist KW-3635 reduces infarct size in a canine model of coronary occlusion and reperfusion Arch Int Pharmacodyn Ther 323 1993 32
16. A.M. Bhat, H. Sacks, J.A. Osborne, and A.M. Lefer Protective effect of the specific thromboxane receptor antagonist, BM-13505, in reperfusion injury following acute myocardial ischemia in cats Am Heart J 117 1989 799
17. P. Golino, G. Ambrosio, and B. Villari Endogenous prostaglandin endoperoxides may alter infarct size in the presence of thromboxane synthase inhibition: studies in a rabbit model of coronary artery occlusion-reperfusion J Am Coll Cardiol 21 1993 493
18. Z.D. Ge, J.A. Auchampach, G.M. Piper, and G.J. Gross Comparison of cardioprotective efficacy of two thromboxane A2 receptor antagonists J Cardiovasc Pharmacol 41 2003 481
19. S. Rolin, J.M. Dogne, C. Michaux, J. Delarge, and B. Masereel Activity of a novel dual thromboxane A(2)receptor antagonist and thromboxane synthase inhibitor (BM-573) on platelet function and isolated smooth muscles Prostaglandins Leukot Essent Fatty Acids 65 2001 67
20. S. Rolin, M. Petein, and V. Tchana-Sato BM-573, a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, prevents pig myocardial infarction induced by coronary thrombosis J Pharmacol Exp Ther 306 2003 59
21. Dogne JM, Hanson J, de Leval X, et al. Pharmacological characterization of N-tert-butyl-N′-[2-(4′-methylphenylamino)-5-nitrobenzenesulfonyl] urea (BM-573), a novel thromboxane A2 receptor antagonist and thromboxane synthase inhibitor in a rat model of arterial thrombosis and its effects on bleeding time. J Pharmacol Exp Ther 2004;309:498.
22. J. Baan, E.T. van der Velde, and H.G. De Bruin Continuous measurement of left ventricular volume in animals and humans by conductance catheter Circulation 70 1984 812
23. H. Suga, A. Kitabatake, and K. Sagawa End-systolic pressure determines stroke volume from fixed end-diastolic volume in the isolated canine left ventricle under a constant contractile state Circ Res 44 1979 238
24. H. Suga External mechanical work from relaxing ventricle Am J Physiol 236 1979 H494 (Heart Circ Physiol 5)
25. S. Denslow Relationship between PVA and myocardial oxygen consumption can be derived from thermodynamics Am J Physiol 270 1996 H730 (Heart Circ Physiol 39)
26. N. Westerhof, G. Elzinga, and P. Sipkema An artificial arterial system for pumping hearts J Appl Physiol 31 1971 776
27. B. Lambermont, P. Kolh, O. Detry, P. Gerard, R. Marcelle, and V. D'Orio Analysis of endotoxin effects on the intact pulmonary circulation Cardiovasc Res 41 1999 275
28. K. Sagawa L. Maughan H. Suga K. Sunagawa Cardiac contraction and the pressure-volume relationship 1988 Oxford University Press New York
29. D.C. Warltier, M.G. Zyvoloski, G.J. Gross, H.F. Hardman, and H.L. Brooks Determination of experimental myocardial infarct size J Pharmacol Methods 6 1981 199
30. K. Higo, A. Karasawa, and K. Kubo Early thrombolysis by recombinant tissue-plasminogen activator is beneficial to the ischemic myocardium J Pharmacobiodyn 15 1992 33
31. J.T. Lie, P.C. Pairolero, K.E. Holley, and J.L. Titus Macroscopic enzyme-mapping verification of large, homogeneous, experimental myocardial infarcts of predictable size and location in dogs J Thorac Cardiovasc Surg 69 1975 599
32. M.C. Fishbein, S. Meerbaum, and J. Rit Early phase acute myocardial infarct size quantification: validation of the triphenyl tetrazolium chloride tissue enzyme staining technique Am Heart J 101 1981 593
33. K. Sunagawa, W.L. Maughan, and K. Sagawa Effect of regional ischemia on the left ventricular end-systolic pressure-volume relationship of isolated canine hearts Circ Res 52 1983 170
34. D.A. Kass, P. Marino, W. Maughan, and K. Sagawa Determinants of end-systolic pressure-volume relations during acute regional ischemia in situ Circulation 80 1989 1783
35. R. Coleman, I. Kennedy, and P. Humphrey Comprehensive medicinal chemistry vol. 3: membranes and receptors J. Emmett Prostanoids and their receptors 1990 Pergamon Press Oxford, UK 643
36. S.J. Coker, J.R. Parratt, I.M. Ledingham, and I.J. Zeitlin Thromboxane and prostacyclin release from ischaemic myocardium in relation to arrhythmias Nature 291 1981 323
37. N. Bowling, G.P. Dube, and W.L. Kurtz Characterization of thromboxane A2/prostaglandin H2 binding sites in guinea pig cardiac membrane preparations J Mol Cell Cardiol 26 1994 915
38. T. Imamoto, Z. Terashita, M. Tanabe, K. Nishikawa, and M. Hirata Protective effect of a novel thromboxane synthetase inhibitor, CV-4151, on myocardial damage due to coronary occlusion and reperfusion in the hearts of anesthetized dogs J Cardiovasc Pharmacol 8 1986 832
39. K.M. Mullane, and D. Fornabaio Thromboxane synthetase inhibitors reduce infarct size by a platelet-dependent, aspirin-sensitive mechanism Circ Res 62 1988 668
40. W.W. Nichols, J. Mehta, T.J. Wargovich, D. Franzini, and D. Lawson Reduced myocardial neutrophil accumulation and infarct size following thromboxane synthetase inhibitor or receptor antagonist Angiology 40 1989 209
41. K. Schror, and C. Thiemermann Treatment of acute myocardial ischaemia with a selective antagonist of thromboxane receptors (BM 13.177) Br J Pharmacol 87 1986 631
42. M.E. Brezinski, A. Yanagisawa, and A.M. Lefer Cardioprotective actions of specific thromboxane receptor antagonist in acute myocardial ischemia J Cardiovasc Pharmacol 9 1987 65
43. C.E. Hock, M.E. Brezinski, and A.M. Lefer Anti-ischemic actions of a new thromboxane receptor antagonist, SQ-29,548, in acute myocardial ischemia Eur J Pharmacol 122 1986 213
44. T. Hohlfeld, J. Meyer-Kirchrath, Y.C. Vogel, and K. Schror Reduction of infarct size by selective stimulation of prostaglandin EP(3) receptors in the reperfused ischemic pig heart J Mol Cell Cardiol 132 2000 285
45. F. White, and C. Bloor Coronary collateral circulation in the pig: correlation of collateral flow with coronary bed size Basic Res Cardiol 76 1981 189
46. W. Schaper, G. Görge, B. Winkler, and J. Schaper The collateral circulation of the heart Prog Cardiovasc Dis 31 1988 57
47. S. Miyazaki, H. Fujiwara, and T. Onodera Quantitative analysis of contraction band and coagulation necrosis after ischemia and reperfusion in the porcine heart Circulation 75 1987 1074
48. I.M. Taylor, N.A. Shaikh, and E. Downar Ultrastructural changes of ischemic injury due to coronary artery occlusion in the porcine heart J Mol Cell Cardiol 16 1984 79
49. R.B. Jennings, and C.E. Ganote Mitochondrial structure and function in acute myocardial ischemic injury Circ Res 38 Suppl. 1 1976 I80
50. L.C. Becker, R.W. Jeremy, J. Schaper, and W. Schaper Ultrastructural assessment of myocardial necrosis occurring during ischemia and 3-h reperfusion in the dog Am J Physiol 277 1999 H243
51. L. Ryden, H. Tadokoro, and P.O. Sjoquist Pharmacokinetic analysis of coronary venous retro infusion: a comparison with anterograde coronary artery drug administration using metoprolol as a tracer J Am Coll Cardiol 18 1991 603
52. C.Y. Xiao, A. Hara, and K. Yuhki Roles of prostaglandin I(2) and thromboxane A(2) in cardiac ischemia-reperfusion injury: a study using mice lacking their respective receptors Circulation 104 2001 2210