Some factors affecting the stability of interferon alpha 2b in solution

Biologicals

Volumn 34, Issue 1 SPEC. ISS., 2006, Pages 15-19

  Ruiz, Llamil ^a   Reyes, Nuria ^a   Aroche, Kethia ^a   Báez, Reynier ^a   Aldana, Raymersy ^a   Hardy, Eugenio ^a  

^a CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

Author keywords

Albumin free formulation; Interferon; Protein concentration; Stability

Indexed keywords

ALBUMIN; DISODIUM HYDROGEN PHOSPHATE; DRUG VEHICLE; EDETATE DISODIUM; METHYL PARABEN; POLYSORBATE 80; PROPYL PARABEN; RECOMBINANT ALPHA2B INTERFERON; SODIUM DIHYDROGEN PHOSPHATE; STABILIZING AGENT;

ACCELERATION; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; DRUG FORMULATION; DRUG MEGADOSE; DRUG PURITY; DRUG SCREENING; DRUG STABILITY; HUMAN; HUMAN CELL; LIQUID; LOW DRUG DOSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SAMPLE; STORAGE TEMPERATURE; VIRUS TITRATION;

EID: 33644531615     PISSN: 10451056     EISSN: 10958320     Source Type: Journal    
DOI: 10.1016/j.biologicals.2005.07.002     Document Type: Article

References (17)

1. A. Isaacs, and J. Lindenman Virus interference-1. The interferons Proc R Soc Lond B Biol Sci 147 1957 258 267
2. R. Bordens, S.E. Grossberg, P.P. Trotta, and T.L. Nagabhushan Molecular and biologic characterization of recombinant interferon-alpha2b Semin Oncol 24 1997 S9-41 S9-51
3. Requirements for human interferons made by recombinant DNA techniques 1988 World Health Organization Technical Series No. 771
4. A. Sasson Biotecnologías aplicadas a la producción de fármacos y vacunas 1998 Elfos Scientiae Ciudad de la Habana
5. A. Beldarraín, C. Cruz, O. Cruz, M. Navarro, and M. Gil Purification and conformational properties of a human interferon alpha 2b produced in Escherichia coli Biotechnol Appl Biochem 33 2001 173 182
6. Kwan HK. Biologically stable alpha-interferon formulations. United States Patent 4496537; 1985.
7. Gross G, Del Terzo S, Kumar S. Stabilizer interferon alpha solutions. United States Patent 5762923; 1998.
8. L.l. Ruiz, N. Reyes, L. Duany, A. Franco, K. Aroche, and E. Hardy Long-term stabilization of recombinant human interferon α 2b in aqueous solution without serum albumin Int J Pharm 264 2003 57 72
9. J. Ferrero, M.E. Ochagavía, A. Aguilera, and P. López-Saura Interferon antiviral activity titration using the "SUMA" device system Biotecnol Apl 11 1994 34 42
10. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
11. USP 26 2003 United States Pharmacopoeia Convention, Inc. Rockville, MD
12. British pharmacopoeia 1998 London, U.K.
13. H. Santana, Y. Espino, A. Franco, G. Furrazola, and E. Hardy A sandwich-type enzyme-linked immunosorbent assay for the analysis of recombinant human interferon α-2b Biotechnol Tech 5 1999 341 346
14. D.N. Lecker, and A. Khan Theoretical and experimental studies of the effects of heat, EDTA, and enzyme concentration on the inactivation rate of alpha amylase from Bacillus sp. Biotechnol Prog 12 1996 713 717
15. W. Wang Instability, stabilization, and formulation of liquid protein pharmaceuticals Int J Pharm 185 1999 129 188
16. R.W. Ruddon, and E. Bedows Assisted protein folding J Biol Chem 272 1997 3125 3128
17. J.R. Hart Chelating agents as preservatives potentiators J.J. Kabara Cosmetic and drug preservation: principles and practices Cosmetic science and technology series vol. I 1984 Marcel Dekker New York 323 337