Putative antinociceptive effect of alpha-tocopherol in mice

Pain Clinic

Volumn 18, Issue 1, 2006, Pages 57-62

  Kilic, Fatma Sultan ^a   Sirmagul, Basar ^a   Oner, Setenay ^a   Erol, Kevser ^a  

^a ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

Author keywords

Alpha tocopherol; Analgesic effects; Mice

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; ANTIOXIDANT; ARGININE; DIPYRONE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; MALE; MOUSE; NONHUMAN;

EID: 33644525627     PISSN: 01691112     EISSN: None     Source Type: Journal    
DOI: 10.1163/156856906775249893     Document Type: Article

References (36)

1. Edmonds SE, Winyard PG, Guo R, et al., Putative analgesic activity of repeated oral doses of Vitamin E in the treatment of rheumatoid arthritis. Results of a prospective placebo controlled double blind trial, Annals Rheum Dis 56, 649-55 (1997).
2. Fairbuirn K, Burton G, Ingold K, et al., Is there an increased need for antioxidant vitamins in rheumatoid arthritis? Br J Rheumatol 33, 153 (1994).
3. Wittenborg A, Petersen G, Lorkowski G, et al., Effectivenes of vitamin E in comparison with diclofenac sodium in treatment of patients with chronic poliarthritis, Z Rheumatol 57, 215-21 (1998).
4. Machtey I, Ouaknine L, Tocopherol in osteoarthritis: a controlled pilot study, J Amer Geriat Soc 26, 328-30 (1978).
5. Kolarz G, Scharek O, Shohoumi MEL, et al., Hochdosiertes Vitamin E bei chronisher Polyarthritis, Aktuelle Rheumatologie 15, 233-7 (1990).
6. Douglas C, Chan AC, Choy PC, Vitamin E inhibits platelet phospholipase A2, Biochim Biophys Acta 876, 639-45 (1986).
7. Redanna P, Rao MK, Reddy CC, Inhibition of 5-lipoxygenase by vitamin E, FEBS Lett 193, 39-43 (1995).
8. Burton GW, Joyce A, Ingold KU, First proof that Vitamin E is the major lipid-soluble, chain-breaking antioxidant in human blood plasma, Lancet 2, 327-33 (1982).
9. Burton GW, Ingold KU, Vitamin E as an in vitro and in vivo antioxidant, Ann NY Acad Sci 570, 7-22 (1989).
10. Packer L, Kagan E, Vitamin E: the antioxidant harvesting center of membranes and lipoproteins, in: Vitamin E Health and Disease, Packer L, Fochs L (Eds), pp. 179-99, Marcel Decker, New York (1993).
11. de Groot, H, Hegi U, Sies H, Loss of alpha-tocopherol upon exposure to nitric oxide or the sydnonimine SIN-1, FEBS Lett 315, 139-42 (1993).
12. Azzi A, Ricciarelli R, Zingg JM, Non-antioxidant molecular functions of alpha-tocopherol (Vitamin E), FEBS Lett 519, 8-10 (2002).
13. Moody EJ, Simon BA, Johns RA, Therapeutic gases, oxygen, carbon dioxide, nitric oxide, and helium, in: Goodman and Gilman's Pharmacological Basis of Therapeutics, Hardman JG, Limbird LE, Gilman AG (Eds), 10th edn, pp. 385-97. McGraw-Hill, New York (2001).
14. Moore PK, Oluyomi AO, Babbedge RC, et al., MS,L: L-NG- nitro arginine methyl ester exhibits antinociceptive activity in mouse, Brit J Pharmacol 102, 198-202 (1991).
15. Bianchi C, Franceshini J, Experimental observations of Haffner's method for testing analgesic drugs, Brit J Pharmacol 9, 280-4 (1954).
16. Dajani EZ, Larsen KR, Taylor J, et al., 1′,1′-Dimethyl-8- tetrahydrocannabinol-11-oic acid: a novel, orally effective cannabinoid with analgesic and anti-inflammatory properties, J Pharmacol Exp Ther 291, 31-8 (1999).
17. D'Amour FE, Smith DL, A method for determining loss of pain sensation, J Pharmacol Exp Ther 72, 74-79 (1941).
18. Eddy NB, Leinbach D, Synthetic analgesics (II): Dithienylbutenyl and dithienylbutylamines, J Pharmacol Exp Ther 107, 385-97 (1953).
19. Valverde O, Maldanado R, Fournie-Zahiski MC, et al., Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins, J Pharm Exp Ther 270, 77-88 (1994).
20. Schmauss C, Yaksh TL, In vivo studies an spinal opiate receptor systems mediating antinociception II. Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visseral chemical and cutaneous thermal stimuli in the rat, J Pharm Exp Ther 228, 1-12 (1984).
21. Budzinski M, Misterek K, Gumulka W, et al., Inhibition of inducible nitric oxide synthase in persistent pain, Life-Sci 66, 301-5 (2000).
22. Kawamata T, Omote K, Activation of spinal N-methyl-D-aspartate receptors stimulates a nitric oxide (cyclic guanosine-3,5-monophosphate) glutamate release cascade in nociceptive signalling, Anesthesiology 91, 1415-24 (1999).
23. Ashina M, Lassen LH, Bendtsen L, et al., Inhibition of nitric-oxide synthase has an analgesic effect in chronic pain, Ugeskr Laeger 67, 171-3 (2000).
24. Kayaalp SO, Rasyonel tedavi yönünden, Tibbi Farmakoloji 9, 384-97 (2000).
25. Machelska H, Labuz D, Przewlocki R, et al., Inhibition of nitric opxide synthase enhances antinociception mediated by mu, delta, and kappa opioid receptors in acute and prolonged pain in rat spinal cord, J Pharm Eexp Ther 282, 977-84 (1997).
26. Dambisya YM, Lee TL, Effects L-NG-nitro arginine methyl ester (L-NAME), L-NG-monomethyl arginine (L-NMMA) and L-arginine on the antinociceptive effects of morphine in mice, Methods Find Exp Clin Pharmacol 9, 577-82 (1995).
27. Kawabata A, Mamalac S, Manobe Y, et al., Effect of topical administration of L-arginine on formalin-induced nociception in the mause: a dual role of peripherally formed NO in pain modulation, Br J Pharmacol 112, 547-50 (1994).
28. Gupta RC, Milatovic D, Dettbarn WD, Nitric oxide modulates high-energy phosphates in brain regions of rats intoxicated with diisopropylphosphorofluoridate or carbofuran: prevention by N-tert-butyl-alpha- phenylnitrone or vitamin E, Arch Toxicol 75, 346-56 (2001).
29. Wei ZY, Roering SC, Spinal morphine clonidine antinociceptive synergism is regulated by protein kinase C, but not protein kinase A activity, J Pharm Exp Ther 287, 937-43 (1998).
30. Hoffman BB, Taylor P, Neurotransmission the autonomie and somatic motor nervous systems, in: Goodman and Gilman's Pharmacological Basis of Therapeutics, Hardman JG, Limberd LE, Gilman AG, (Eds), 10th edn, pp. 115-55. McGraw-Hill, New York (2001).
31. Tasinato A, Boscoboinik D, Bartoli M, et al., d-Alpha-tocopherol inhibition of vascular smooth moscle cell proliferation occurs at physiological concentration correlates with protein kinase C inhibition and is independent of its antioxidant properties, Proc Natl Acad Sci USA 92, 12190-4 (1995).
32. Herbert V, The antioxidant supplement myth, Am J Clin Nutr 60, 157-8 (1994).
33. Chow CK, Hong CB, Dietary vitamin E and selenium and toxicity of nitrite and nitrate, Toxicology 180, 195-207 (2002).
34. Freedman JE, Li L, Sauter R, et al., Alpha-tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide release, FASEB J 14, 2377-9 (2000).
35. Fukuzawa K, Kogure K, Morita M, et al., Tokumura A: enhancement of nitric-oxide and superoxide generation by alpha-tocopheryl succinate and its apoptotic and anticancer effects, Biochemistry (Mosc) 69, 50-7 (2004).
36. Green D, O'Driscoll G, Ramkin JM, et al., Beneficial effect of vitamin E administration on nitric-oxide function in subjects with hypercholesterolemia, Clin Sci (Lond) 95, 361-7 (1998).