Clinical and molecular features of a TSH-secreting pituitary microadenoma

Pituitary

Volumn 8, Issue 2, 2005, Pages 127-134

  Usui, Takeshi ^a   Izawa, Shoichiro ^b   Sano, Toshiaki ^c   Tagami, Tetsuya ^b   Nagata, Daisuke ^a   Shimatsu, Akira ^b   Takahashi, Jun A ^d   Naruse, Mitsuhide ^a  

^a Clinical Research Center   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION KYOTO MEDICAL CENTER   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

RT PCR; Somatostatin receptor; Thyroid hormone receptor; Transcription factor; Transcriptional cofactor; TSH secreting adenoma

Indexed keywords

GROWTH HORMONE; HYPOPHYSIS HORMONE; LIOTHYRONINE; NUCLEAR RECEPTOR COACTIVATOR 2; NUCLEAR RECEPTOR COREPRESSOR; PROLACTIN; SOMATOSTATIN RECEPTOR 1; SOMATOSTATIN RECEPTOR 4; STEROID RECEPTOR COACTIVATOR 1; STEROID RECEPTOR COACTIVATOR 3; THYROID HORMONE RECEPTOR BETA; THYROTROPIN; THYROXINE; TRANSCRIPTION FACTOR PIT 1;

ADULT; ALPHA CHAIN; ARTICLE; CASE REPORT; CLINICAL FEATURE; FEMALE; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE MUTATION; HISTOPATHOLOGY; HORMONE DETERMINATION; HUMAN; HYPOPHYSIS ADENOMA; IMMUNOPHENOTYPING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; SURGICAL TECHNIQUE; THYROTROPIN BLOOD LEVEL; TRANSSPHENOIDAL SURGERY;

ADENOMA; FEMALE; HUMANS; MIDDLE AGED; PITUITARY NEOPLASMS; POLYMERASE CHAIN REACTION; THYROID HORMONE RECEPTORS BETA; THYROTROPIN; THYROTROPIN-RELEASING HORMONE; TRIIODOTHYRONINE;

EID: 33644518451     PISSN: 1386341X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11102-005-3759-4     Document Type: Article

References (24)

1. Beck-Peccoz P, Brucker-Davis F, Persani L, Smallridge RC, Weintraub BD. Thyrotropin-secreting pituitary tumors. Endocr Rev 1996;17:610-638.
2. Brucker-Davis F, Oldfield EH, Skarulis MC, Doppman JL, Weintraub BD. Thyrotropin-secreting pituitary tumors: Diagnostic criteria, thyroid hormone sensitivity, and treatment outcome in 25 patients followed at the National Institutes of Health. J Clin Endocrinol Metab 1999;84:476-486.
3. Akiyoshi F, Okamura K, Fujikawa M, Sato K, Yoshinari M, Mizokami T, Hattori K, Kuwayama A, Takahashi Y, Fujishima M. Difficulty in differentiating thyrotropin secreting pituitary microadenoma from pituitary-selective thyroid hormone resistance accompanied by pituitary incidentaloma. Thyroid 1996;6:619-625.
4. Safer JD, Colan SD, Fraser LM, Wondisford FE. A pituitary tumor in a patient with thyroid hormone resistance: A diagnostic dilemma. Thyroid 2001;11:281-291.
5. Refetoff S, Weiss RE, Usala SJ. The syndromes of resistance to thyroid hormone. Endocr Rev 1993;14:348-399.
6. Weiss RE, Tunca H, Knapple WL, Faas FH, Refetoff S. Phenotype differences of resistance to thyroid hormone in two unrelated families with an identical mutation in the thyroid hormone receptor beta gene (R320C). Thyroid 1997;7:35-38.
7. Jameson JL. Mechanisms by which thyroid hormone receptor mutations cause clinical syndromes of resistance to thyroid hormone. Thyroid 1994;4:485-492.
8. Aron DC, Howlett TA. Pituitary incidentalomas. Endocrinol Metab Clin North Am 2000;29:205-221.
9. Sanno N, Oyama K, Tahara S, Teramoto A, Kato Y. A survey of pituitary incidentaloma in Japan. Eur J Endocrinol 2003;149:123-127.
10. Dong Q, Brucker-Davis F, Weintraub BD, Smallridge RC, Carr FE, Battey J, Spiegel AM, Shenker A. Screening of candidate oncogenes in human thyrotroph tumors: Absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes. J Clin Endocrinol Metab 1996;81:1134-1140.
11. Reutrakul S, Sadow PM, Pannain S, Pohlenz J, Carvalho GA, Macchia PE, Weiss RE, Refetoff S. Search for abnormalities of nuclear corepressors, coactivators, and a coregulator in families with resistance to thyroid hormone without mutations in thyroid hormone receptor beta or alpha genes. J Clin Endocrinol Metab 2000;85:3609-3617.
12. Sarlis NJ, Gourgiotis L, Koch CA, Skarulis MC, Brucker-Davis F, Doppman JL, Oldfield EH, Patronas NJ. MR imaging features of thyrotropin-secreting pituitary adenomas at initial presentation. AJR Am J Roentgenol 2003;181:577-582.
13. Li S, Crenshaw EB, 3rd, Rawson EJ, Simmons DM, Swanson LW, Rosenfeld MG. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature 1990;347:528-533.
14. Nakamura Y, Usui T, Mizuta H, Murabe H, Muro S, Suda M, Tanaka K, Tanaka I, Shimatsu A, Nakao K. Characterization of Prophet of Pit-1 gene expression in normal pituitary and pituitary adenomas in humans. J Clin Endocrinol Metab 1999;84:1414-1419.
15. Lamolet B, Pulichino AM, Lamonerie T, Gauthier Y, Brue T, Enjalbert A, Drouin J. A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins. Cell 2001;104:849-859.
16. Vallette-Kasic S, Figarella-Branger D, Grino M, Pulichino AM, Dufour H, Grisoli F, Enjalbert A, Drouin J, Brue T. Differential regulation of proopiomelanocortin and pituitary-restricted transcription factor (TPIT), a new marker of normal and adenomatous human corticotrophs. J Clin Endocrinol Metab 2003;88:3050-3056.
17. Ando S, Sarlis NJ, Krishnan J, Feng X, Refetoff S, Zhang MQ, Oldfield EH, Yen PM. Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance. Mol Endocrinol 2001;15:1529-1538.
18. Ando S, Sarlis NJ, Oldfield EH, Yen PM. Somatic mutation of TRbeta can cause a defect in negative regulation of TSH in a TSH-secreting pituitary tumor. J Clin Endocrinol Metab 2001;86:5572-5576.
19. Chanson P, Li JY, Le Dafniet M, Derome P, Kujas M, Murat A, Charpentier G, Racadot J, Peillon F. Absence of receptors for thyrotropin (TSH)-releasing hormone in human TSH-secreting pituitary adenomas associated with hyperthyroidism. J Clin Endocrinol Metab 1988;66:447-450.
20. Tagami T, Madison LD, Nagaya T, Jameson JL. Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone. Mol Cell Biol 1997;17:2642-2648.
21. Takeuchi Y, Murata Y, Sadow P, Hayashi Y, Seo H, Xu J, O'Malley BW, Weiss RE, Refetoff S. Steroid receptor coactivator-1 deficiency causes variable alterations in the modulation of T(3)-regulated transcription of genes in vivo. Endocrinology 2002;143:1346-1352.
22. Miller GM, Alexander JM, Bikkal HA, Katznelson L, Zervas NT, Klibanski A. Somatostatin receptor subtype gene expression in pituitary adenomas. J Clin Endocrinol Metab 1995;80:1386-1392.
23. Murabe H, Shimatsu A, Ihara C, Mizuta H, Nakamura Y, Nagata I, Kikuchi H, Nakao K. Expression of somatostatin receptor (SSTR) subtypes in pituitary adenomas: Quantitative analysis of SSTR2 mRNA by reverse transcription-polymerase chain reaction. J Neuroendocrinol 1996;8:605-610.
24. Nielsen S, Mellemkjaer S, Rasmussen LM, Ledet T, Olsen N, Bojsen-Moller M, Astrup J, Weeke J, Jorgensen JO. Expression of somatostatin receptors on human pituitary adenomas in vivo and ex vivo. J Endocrinol Invest 2001;24:430-437.