A novel resolution of a pharmaceutically important bridged bicyclic ketone intermediate via selective enzymatic reduction with a commercially available ketoreductase

Journal of Molecular Catalysis B: Enzymatic

Volumn 38, Issue 3-6, 2006, Pages 158-162

  Truppo, Matthew D ^a   Kim, Jaehon ^a   Brower, Mark ^a   Madin, Andrew ^a   Sturr, Michael G ^a   Moore, Jeffrey C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Bicyclic; Bridged; Ketone; Ketoreductase; Stereoselective

Indexed keywords

ENZYME KINETICS; ENZYMES; ORGANIC SOLVENTS; REACTION KINETICS; STEREOCHEMISTRY;

BICYCLIC; BRIDGED; KETOREDUCTASE; STEREOSELECTIVE;

KETONES;

11 OXO 5,6,7,9,10 HEXAHYDRO 6,9 METHANOBENZOCYCLOOCTENE; CYCLODEXTRIN; KETONE DERIVATIVE; ORGANIC COMPOUND; SOLVENT; UNCLASSIFIED DRUG;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CATALYSIS; CHEMICAL REACTION KINETICS; ENANTIOMER; ENZYME KINETICS; ENZYME SUBSTRATE; NONHUMAN; STEREOCHEMISTRY; TEMPERATURE;

ANIMALIA;

EID: 33644512730     PISSN: 13811177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcatb.2006.01.001     Document Type: Article

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