Chromosomal change during 6-mercaptopurine (6-MP) therapy in juvenile myelomonocytic leukemia: The growth of a 6-MP-refractory clone that already exists at onset

Leukemia

Volumn 20, Issue 3, 2006, Pages 485-490

  Matsuda, K ^a   Matsuzaki, S ^b   Miki, J ^b   Hidaka, E ^a   Yanagisawa, R ^b   Nakazawa, Y ^b   Sakashita, K ^b   Kamijo, T ^b   Asami, K ^c   Sano, K ^a   Koike, K ^b  

^a SHINSHU UNIVERSITY HOSPITAL   (Japan)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NIIGATA CANCER CENTER HOSPITAL   (Japan)

Author keywords

6 MP; Chromosomal change; FISH; JMML; PTPN11

Indexed keywords

CYTARABINE; ETOPOSIDE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MERCAPTOPURINE; PREDNISOLONE; PROTEIN TYROSINE PHOSPHATASE SHP 2; RETINOIC ACID;

ARTICLE; BONE MARROW CELL; CELL CULTURE; CHILD; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME G BAND; CLINICAL ARTICLE; CLONOGENESIS; CYTOGENETICS; DISEASE COURSE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GENE MUTATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; JUVENILE MYELOMONOCYTIC LEUKEMIA; KARYOTYPING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TREATMENT RESPONSE; TRISOMY 8;

EID: 33644502897     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404106     Document Type: Article

References (16)

1. Niemeyer CM, Fenu S, Hasle H, Mann G, Stary J, van Wering E. Differentiating juvenile myelomonocytic leukemia from infectious disease. Blood 1998; 91: 365-367.
2. Tartaglia M, Niemeyer CM, Fragale A, Song X, Buechner J, Jung A et al. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet 2003; 34: 148-150.
3. Le DT, Kong N, Zhu Y, Lauchle JO, Aiyigari A, Braun BS et al. Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. Blood 2004; 103: 4243-4250.
4. Side L, Taylor B, Cayouette M, Conner E, Thompson P, Luce M et al. Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders. N Engl J Med 1997; 336: 1713-1720.
5. Kalra R, Paderanga DC, Olson K, Shannon KM. Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras. Blood 1994; 84: 3435-3439.
6. Niemeyer CM, Aricó M, Basso G, Biondi A, Cantu Rajnoldi A, Creutzig U et al. Chronic myelomonocytic leukemia in childhood: A retrospective analysis of 110 cases. European Working Group on Myelodysplastic Syndromes in Childhood (EWOG-MDS). Blood 1997; 89: 3534-3543.
7. Hasle H, Baumann I, Bergsträsser E, Fenu S, Fischer A, Kardos G et al. European Working Group on childhood MDS. The International Prognostic Scoring System (IPSS) for childhood myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML). Leukemia 2004; 18: 2008-2014.
8. Lutz P, Zix-Kieffer I, Souillet G, Bertrand Y, Dhooge C, Rubie C et al. Juvenile myelomonocytic leukemia: Analyses of treatment results in the EORTC Children's Leukemia Cooperative Group (CLCG). Bone Marrow Transplantation 1996; 18: 1111-1116.
9. Woods WG, Barnard DR, Alonzo TA, Buckley JD, Kobrinsky N, Arthur DC et al. Prospective study of 90 children requiring treatment for juvenile myelomonocytic leukemia or myelodysplastic syndrome: A report from the Children's Cancer Group. J Clin Oncol 2002; 20: 434-440.
10. Manabe A, Okamura J, Yumura-Yagi K, Akiyama Y, Sako M, Uchiyama H et al. MDS Committee of the Japanese Society of Pediatric Hematology. Allogeneic hematopoietic stem cell transplantation for 27 children with juvenile myelomonocytic leukemia diagnosed based on the criteria of the International JMML Working Group. Leukemia 2002; 16: 645-649.
11. Kosaki K, Suzuki T, Muroya K, Hasegawa T, Sato S, Matsuo N et al. PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome. J Clin Endocrinol Metab 2002; 87: 3529-3533.
12. Mitani K, Hangaishi A, Imamura N, Miyagawa K, Ogawa S, Kanda Y et al. No concomitant occurrence of the N-ras and p53 gene mutations in myelodysplastic syndromes. Leukemia 1997; 11: 863-865.
13. Kobayashi N, Matsuda K, Sakashita K, Matsuzaki S, Iwasaki R, Koike K. Bilineage acute leukemia of T-lymphoid and myeloid lineages. Haematologica 2004; 89: 1139-1141.
14. Sawai N, Koike K, Higuchi T, Ogami K, Oda M. Thrombopoietin enhances the production of myeloid cells, but not megakaryocytes, in juvenile chronic myelogenous leukemia. Blood 1998; 91: 4065-4073.
15. Sakashita K, Koike K, Kinoshita T, Shiohara M, Kamijo T, Taniguchi S et al. Dynamic DNA methylation change in the CpG island region of p15 during human myeloid development. J Clin Invest 2001; 108: 1195-1204.
16. Locatelli F, Nöllke P, Zecca M, Korthof E, Lanino E, Peters C et al. European Working Group on Childhood MDS; European Blood and Marrow Transplantation Group. Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): Results of the EWOG-MDS/EBMT trial. Blood 2005; 105: 410-419.