Efficacy of two different doses of antilonomic serum in the resolution of hemorrhagic syndrome resulting from envenoming by Lonomia obliqua caterpillars: A randomized controlled trial

Toxicon

Volumn 43, Issue 7, 2004, Pages 811-818

  Caovilla, Jairo José ^a   José Guardão Barros, Elvino ^b  

^a UNIVERSITY OF PASSO FUNDO   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Antilonomic serum; Antivenom; Caterpillar; Clinical trial; Hemorrhagic syndrome; Lonomia obliqua

Indexed keywords

ANTILONOMIC SERUM; ANTISERUM; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; BLEEDING DISORDER; BLOOD CLOTTING; BRAZIL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; HOSPITALIZATION; HUMAN; LABORATORY TEST; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT;

ADOLESCENT; ADULT; ANIMALS; ANTIVENINS; ARTHROPOD VENOMS; BLOOD COAGULATION; BRAZIL; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEMORRHAGE; HUMANS; LARVA; MALE; MOTHS; TIME FACTORS;

LONOMIA; PHACELIA CONGESTA;

EID: 3343005546     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2004.03.014     Document Type: Article

References (29)

1. Arocha-Piñango C.L. Fibrinolisis producida por contacto com orugas comunicacion preliminar. Acta Cient. Venezolana. 18:1967;136-139
2. Arocha-Piñango C.L., Layrisse M. Fiblinolysis produced by contact with a caterpillar. Lancet. 1:1969;810-812
3. Burdmann E.A., Antunes I., Saldanha L.B., Abdulkader R.C.M.R. Severe acute renal failure induced by the venom of Lonomia caterpillars. Clin. Nephrol. 46:(5):1996;337-339
4. Cardoso J.L.C., Fan H.W., França F.O.S., Jorge M.T., Leite R.P., Nishioka S.A., Ávila A., Santo-Martins I.S., Tomy S.C., Santoro M.L., Chudzinski A.M., Castro S.C.B., Kamiguti A.S., Kelen E.M.A., Hirata M.H., Mirandola R.M.S., Theakston R.D.G., Warrel D.A. Randomized comparative trial of three antivenoms in the treatment of envenoming by lance-herded vipers (Bothrops jararaca) in São Paulo, Brazil. QJM. 86:1993;315-325
5. Chudzinski-Tavassi A.M., Schattner M., Fritzen M., Pozner R.G., Reis C.V., Lourenco D., Lazzari M.A. Effects of Lopap on human endothelial cells and platelets. Haemostasis. 31:(3):2001;257-265
6. Dalla Costa, L.R., Gamborgi, G., Faht, M.D., Zannin, M., Grando, M., Moritz, P., Silva, E., Casagrande, M.A.D., Fan, H.W., Cardoso, J.L.C., Kelen, E.M.A., Sano-Martin, I., Higashi, H.G., Yamagushi, I.K., Santos, A.C., Tacca, C.P., 1997. Eficácia do soro antilonomia nos acidentes causados por contato com lagartas em Santa Catarina. 2°Encontro Nacional de Acidentes com Animais Peçonhentos. Porto Alegre, Brasil, Abstract Book, pp. 64.
7. Dias da Silva W., Rocha-Campos A.C.M., Gonçalves L.R.C., Souza-e-Silva M.C., Higashi H.G., Yamagushi I.K., Kelen E.M.A. Development of an antivenom against toxins of Lonomia obliqua caterpillars. Toxicon. 34:1996;1045-1049
8. Donato J.L., Moreno R.A., Hyslop S., Duarte A., Antunes E., Lê Bonniec B.F., Rendu F., Nucci G. Lonomia obliqua caterpillar spicules trigger human blood coagulation via activation of factor X and prothrombin. Thromb. Haemost. 79:1998;539-542
9. Duarte A.C., Caovilla J.J., Lorini I., Lorini D., Mantovani G., Sumida J., Manfre P.C., Silveira R.C., Moura S.P. Insuficiência renal aguda por acidentes com lagartas. JBN. 12:(4):1990;184-187
10. Duarte, A.C., 1997. Síndrome hemorrágica causada por larvas de mariposa do gênero Lonomia: estudo clínico- epidemiológico [Dissertação]. Porto Alegre: Universidade Federal do Rio Grande do Sul.
11. Duarte A., Walter G., Barros E., Lorini I. Insuficiência renal aguda nos acidentes com Lonomia obliqua. Nefrologia Latinoamericana. 1:(1):1994;38-40
12. Duarte A.C., Caovilla J.J., Hermann F., Renner L.O., Santos S.R., Tefilli A.P., Rodrigues C., Butzke L.M.W. Hemorragia gengivo-jugal pós-contato com Lonomia obliqua. Revista Médica HSVP. 9:(20):1997;52-54
13. Duarte, A.C., Caovilla, J.J., Kelen, E.M.A., Wen, F.H., Machado, S.M.S., Hermann, F., Renner, L.O., Santos, S.R., Tefilli, A.P., Rodrigues, C., Butzke, L.M.W., 1997b. Estudo comparativo entre o soro anti-lonômico e o acido aminocapróico. 2°Encontro Nacional de Acidentes com Animais Peçonhentos. Porto Alegre, Brasil, Abstract Book, pp. 65.
14. Fan H.W., Duarte A.C. Acidentes por Lonomia. Cardoso J.L.C.,, et al. Animais peçonhentos no Brasil: biologia, clínica e terapêutica dos acidentes. Sarvier, São Paulo. 2003;224-232
15. Gold B.S., Dart R.C., Barish R.A. Bites of venomous snakes. N Engl J Med. 347:(5):2002;347-356
16. Jorge M.T., Ribeiro L.A. Efeito da redução na dose de soro antibotrópico administrada a pacientes picados por serpentes do gênero Bothrops. Rev. Assoc. Med. Bras. 40:(1):1994;59-62
17. Jorge M.T., Cardoso J.L.C., Castro S.C.B., Ribeiro L., França F.O.S., Sbrogio de Almeida M.E., Kamiguti A.S., Santo-Martins I.S., Santoro M.L., Mancau J.E.C., Warrel D.A., Theakston R.D.G. A randomized blinded comparison of two doses of antivenom in the treatment of Bothrops envenoming in São Paulo, Brazil. Trans. R. Soc. Trop. Med. Hyg. 89:1995;111-114
18. Kelen E.M.A., Picarelli Z.P., Duarte A.C. Hemorrhagic syndrome induced by contact with caterpillars of the genus Lonomia (Saturniidae, Hemileucinae). J. Toxicol. Toxin. Rev. 14:1995;283-308
19. Ministério da Saúde. Manual de diagnóstico e tratamento de acidentes por animais peçonhentos. Acidentes por lepidópteros. 1998;Fundação Nacional de Saúde, Brasília. pp. 75-85
20. Ministério da Saúde, 2003. Agência Nacional de Vigilância Sanitária. Available at: http://www.anvisa.gov.br/ Accessed 14 October 2003.
21. Premawardhena A.P., Silva C.E., Fonseka M.M.D., Gunatilake S.B., Silva H.J. Low dose subcutaneous adrenaline to prevent acute adverse reactions to antivenom serum in people bitten by snakes: randomized, placebo controlled trial. BMJ. 318:1999;1041-1043
22. Reis C.V., Portaro F.C.V., Andrade A.S., Fritzen M., Fernandes B.L., Sampaio C.A.M., Camargo A.C.M., Chudzinski-Tavassi A.M. A prothrombin activator serine protease from the Lonomia obliqua caterpillar venom (Lopap). Thromb. Res. 102:2001;427-436
23. Reis C.V., Farsky S.H.P., Fernandes B.L., Santoro M.L., Oliva M.L.V., Mariano M., Chudzinski-Tavassi A.M. In vivo characterization of Lopap, a prothrombin activator serine protease from the Lonomia obliqua caterpillar venom. Thromb. Res. 102:2001;437-443
24. 2 antibodies revert blood incoagulability resulting from envenoming by Lonomia obliqua caterpillars. Am J Med Hyg. 64:(5,6):2001;283-289
25. Seibert C.S., Shinohara E.M.G., Sano-Martins I.S. In vitro hemolytic of Lonomia obliqua caterpillar bristle extract on human and Wistar rat erythrocytes. Toxicon. 41:2003;831-839
26. The Butantan Institute Antivenom Study Group (BIASG), Theakston R.D.G., Fan H.W., Warrell D.A., Dias da Silva W.D., Ward S.A., Higashi H.G. Use of enzyme immunoassays to compare the effect and assess the dosage regimens of three Brazilian bothrops antivenoms. Am. J. Trop. Med. Hyg. 47:(5):1992;593-604
27. Veiga A.B., Blochtein B., Guimarães J.A. Structures involved in production, secretion and injection of the venom produced by the caterpillar Lonomia obliqua (Lepidoptera, Saturniidae). Toxicon. 39:2001;1343-1351
28. WHO. Progress in the characterization of venoms and standardization of antivenoms. 1981;World Health Organization, Geneva. WHO Offset Publication 58
29. Zannin M., Lourenço D.M., Motta G., Dalla Costa L.R., Gamborgi G.P., Noguti M.A., Chudzinski-Tavassi A.M. Blood coagulation and fibrinolytic factors in 105 patients with hemorrhagic syndrome caused by accidental contact with Lonomia obliqua caterpillar in Santa Catarina, Southern Brazil. Thromb. Haemost. 89:(2):2003;355-364