Emergence in Italy of a Neisseria meningitidis clone with decreased susceptibility to penicillin

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 8, 2004, Pages 3103-3106

  Stefanelli, Paola ^a   Fazio, Cecilia ^a   Neri, Arianna ^a   Sofia, Tonino ^a   Mastrantonio, Paola ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PENICILLIN G;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM ISOLATION; CELL INVASION; GENE; GENE CLUSTER; GENE SEQUENCE; GENETIC ANALYSIS; ITALY; MOLECULAR CLONING; MOSAICISM; NEISSERIA MENINGITIDIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PENA GENE; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

DNA FINGERPRINTING; DNA, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; HUMANS; ITALY; MENINGITIS, MENINGOCOCCAL; MOSAICISM; NEISSERIA MENINGITIDIS; PENICILLIN RESISTANCE; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 3342996642     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.8.3103-3106.2004     Document Type: Article

References (12)

1. Antignac, A., P. Kriz, G. Tzanakaki, J. M. Alonso, and M. K. Taba. 2001. Polymorphism of Neisseria meningitidis penA gene associated with reduced susceptibility to penicillin. J. Antimicrob. Chemother. 47:285-296.
2. Arreaza, L., S. Berrón, S. Fernández, M. I. Santiago, A. Malvar, and J. A. Vázquez. 2000. Investigation for a more virulent variant among the C2b: P1.2,5 Spanish meningococcal epidemic strains by molecular epidemiology. J. Med. Microbiol. 49:1079-1084.
3. Berrón, S., and J. A. Vázquez. 1994. Increase in moderate penicillin resistance and serogroup C in meningococcal strains isolated in Spain. Is there any relationship? Clin. Infect. Dis. 18:161-165.
4. Hartstein, A., C. Phelps, and A. Lemonte. 1995. Typing of sequential bacterial isolates by pulsed-field gel electrophoresis. Diagn. Microbiol. Infect. Dis. 22:309-314.
5. Kyaw, M. H., J. C. Bramley, S. Clarke, et al. 2002. Prevalence of moderate penicillin resistant invasive Neisseria meningitidis infection in Scotland, 1994-9. Epidemiol. Infect. 128:149-156.
6. Maiden, M. C. J., J. A. Bygraves, E. Feil, et al. 1998. Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc. Natl. Acad. Sci. USA 95:3140-3145.
7. Mastrantonio, P., P. Stefanelli, C. Fazio, T. Sofia, A. Neri, G. La Rosa, C. Marianelli, M. Muscillo, M. G. Caporali, and S. Salmaso. 2003. Serotype distribution, antibiotic susceptibility, and genetic relatedness of Neisseria meningitidis strains recently isolated in Italy. Clin. Infect. Dis. 36:422-428.
8. Richter, S. S., K. A. Gordon, P. R. Rhomberg, M. A. Pfaller, and R. N. Jones. 2001. Neisseria meningitidis with decreased susceptibility to penicillin: report from the SENTRY antimicrobial surveillance program, North America, 1988-99. Diagn. Microbiol. Infect. Dis. 41:83-88.
9. Spratt, B. G., and K. D. Cromie. 1988. Penicillin-binding proteins of gram-negative bacteria. Rev. Infect. Dis. 10:699-711.
10. Stefanelli, P., A. Carattoli, A. Neri, C. Fazio, and P. Mastrantonio. 2003. Prediction of decreased susceptibility to penicillin of Neisseria meningitidis strains by real-time PCR. J. Clin. Microbiol. 41:4666-4670.
11. Stefanelli, P., C. Fazio, A. Neri, T. Sofia, and P. Mastrantonio. 2003. First report of capsule replacement among electrophoretic type 37 Neisseria meningitidis strains in Italy. J. Clin. Microbiol. 41:5783-5786.
12. Tomasz, A. 1986. Penicillin-binding proteins and the antibacterial effectiveness of beta-lactam antibiotics. Rev. Infect. Dis. 8:S260-S278.