Effect of abouthiouline, a novel drug with therapeutic potential as antithyroid, on some biochemical and hematologic parameters in mice and rats

Saudi Pharmaceutical Journal

Volumn 14, Issue 1, 2006, Pages 34-41

  Abou Auda, Hisham S ^a   Abou Shaaban, Rafiq R A ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b AJMAN UNIVERSITY   (United Arab Emirates)

Author keywords

Abouthiouline; Methimazole; Preclinical; Propylthiouracil; Toxicology

Indexed keywords

ABOUTHIOULINE; ALBUMIN; ANTITHYROID AGENT; ELECTROLYTE; GLUCOSE; PROPYLTHIOURACIL; PROTEIN; THIAMAZOLE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BIOCHEMISTRY; BLOOD TOXICITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG SAFETY; ELECTROLYTE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; LEUKOCYTE; LEUKOCYTE COUNT; MOUSE; NEUTROPHIL; NONHUMAN; PARAMETER; RAT; STRUCTURE ACTIVITY RELATION;

EID: 33344466868     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Chiovato L, Santini F, Pinchera A. Treatment of hyperthyroidism. Thyroid Int 1995; 2: 1-22
2. Roti E, Minelli R, Gardini E. Controversies in the treatment of thyrotoxicosis. Adv Endocrinol Metab 1994; 5: 429-460.
3. Klein I, Becker DV, Levey GS 1994 Treatment of hyperthyroid disease. Ann Intern Med 121: 281-288
4. Bartalena L, Bogazzi F, Martino E 1996 Adverse effects of thyroid hormone preparations and antithyroid drugs. Drug Safety 15: 53-63
5. Tajiri J, Noguchi S, Murakami T, Murakam T. Antithyroid drug-induced agranulocytosis: the usefulness of routine white blood cell count monitoring. Arch Intern Med 1990; 150: 621-624
6. Tajiri J, Noguchi S, Okamura S, Morita M, Tamaru M, Murakami N, Niho Y. Granulocyte colony-stimulating factor treatment of antithyroid drug-induced granulocytopenia. Arch Intern Med 1993; 153: 509-514
7. Retsagi G, Kelly JP, Kaufman DW. Risk of agranulocytosis and aplastic anemia in relation to use of antithyroid drugs: international agranulocytosis and aplastic anemia study. BMJ 1988; 297: 262-265
8. Biswas N, Ahn Y, Goldman JM, Schwartz JM. Case report: aplastic anemia associated with antithyroid drugs. Am J Med Sci 1991; 301: 1353-1362
9. Pearce SHS. Spontaneous reporting of adverse reactions to carbimazole and propylthiouracil in the UK. Clin Endocrinol 2004; 61: 589-594
10. Wall JR, Fang SL, Kurocki T, Lagbar SH, Braverman LE. In vitro immunoactivity of propylthiouracil, methimazole and carbizole in patients with Graves' disease: a possible cause of antithyroid drug-induced agranulocytosis. J Clin Endocrinol Metab 1984; 58: 868-872
11. Wilson R, McKillop JH, Travers M, Smith J, Smith E, Thomson JA. The effect of antithyroid drugs on intracellular mediators. Acta Endocrinol Copenh 1990; 122: 605-609
12. Hall LH, Mohney B, Kier LB. The electrotopological state: an atom index for QSAR. Quant. Struct. Act Relat 1991; 10: 43-52
13. Kier LB, Hall LH. An atom description in QSAR models: development and use of an atom level index. In: Testa B (Ed.) Advances in Drug Design, Academic Press Ltd, New York, 1992, pp. 1-38
14. Hall LH, Kier LB. Binding of salicylamides: QSAR analysis with electrotopological state indexes. Med. Chem Res 1992; 2: 497-502
15. Abou-Shaaban RRA, Al-Khamees HA, Abou-Auda HS, Simonelli AP. Atom level electrotopological-state indexes in QSAR: designing and testing antithyroid agents. Pharm Res 1996; 13: 129-136
16. Abou-Shaaban RRA, Al-Khamees HA, Abou-Auda HS, Simonelli AP. Development of new antithyroid compounds with reduced antioxidant property. Saudi Pharm J 1995; 3: 180-195
17. Institute for Laboratory Animal Research. National Research Council. Guide for the Care and Use of Laboratory Animals. Washington DC, National Academy Press, 1996
18. Grebe SKG, Feek CM, Ford HC, Fagerström JN, Cordwell DP, Delahunt JW, Toomath RJ. A randomized trial of short-term treatment of Graves' disease with high-dose carbimazole plus thyroxine versus low-dose carbimazole. Clin Endocrinol 1998; 48: 585-592
19. Maugendre D, Gatel A, Massart C, Guilhem I, Lorcy Y, Lescouarch J, Herry JY, Allannic H. Antithyroid drug and Graves' disease - prospective randomized assessment of long-term treatment. Clin Endocinol 1999; 50: 127-132
20. Meyer-GeBner M, Benker G, Lederbogen S, Olbricht T, Reinwein D. Antithyroid drug-induced agranulocytosis: clinical experience with ten patients treated at one institution and review of the literature. J Endocrinol Invest 1994; 17: 29-36