Common clinicopathological features of the patients with chronic hepatitis B virus infection who developed hepatocellular carcinoma after seroconversion to anti-HBs - A consideration of the pathogenesis of HBV-induced hepatocellular carcinoma and a strategy to inhibit it

Hepato-Gastroenterology

Volumn 53, Issue 67, 2006, Pages 110-114

  Tsuboi, Yasunori ^a   Ohkoshi, Shogo ^b   Yano, Masahiko ^b   Suzuki, Kenta ^b   Tsubata, Syun Suke ^b   Ishihara, Kiyoshi ^b   Ichida, Takafumi ^b   Sugitani, So Ichi ^a   Shibazaki, Ko Ichi ^a   Aoyagi, Yutaka ^b  

^a NIPPON DENTAL UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

Anti HBs; Hepatitis B virus; Hepatocellular carcinoma; Liver cirrhosis; Reduced fibrosis

Indexed keywords

ALANINE AMINOTRANSFERASE; HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; VIRUS DNA;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CANCER INHIBITION; CASE REPORT; CHRONIC HEPATITIS; CLINICAL FEATURE; DISEASE COURSE; HEPATITIS B; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FIBROSIS; MALE; NEEDLE BIOPSY; PATHOGENESIS; PRIORITY JOURNAL; SEROCONVERSION; VIREMIA; VIRUS CARCINOGENESIS;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B, CHRONIC; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED;

EID: 33344461272     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Sampliner RE, Hamilton FA, Iseri OA, Tabor E, Boitnott J: The liver histology and frequency of clearance of the hepatitis B surface antigen (HBsAg) in chronic carriers. Am J Med Sci 1979; 277:17-22.
2. Alward WLM, McMahon BJ, Hall DB, Heyward WL, Franchis DP, Bender TR: The long-term serological course of asymptomatic hepatitis B virus carriers and the development of primary hepatocellular carcinoma. J Infect Dis 1985; 151:604-691.
3. Liaw Y-F, Sheen I-S, Chen T-J, Chu C-M, Pao C-C: Incidence, determinants and significance of delayed clearance of serum HBsAg in chronic hepatitis B virus infection: A prospective study. Hepatology 1991; 13:627-631.
4. Liaw YF, Chen YC, Sheen IS: Spontaneous clearance of hepatitis B surface antigen in chronic hepatitis B virus infection confers a favorable response. Hepatology 1999; 29:296.
5. Perrillo RP, Brunt EM: Hepatic histologic and immunohistochemical changes in chronic hepatitis B after prolonged clearance of hepatitis B e antigen and hepatitis B surface antigen. Ann Intern Med 1991; 115:113-115.
6. Huo TI, Wu JC, Lee PC, Chau GY, Lui WY, Tsay SH, Ting LT, Chang FY, Lee SD: Sero-clearance of hepatitis B surface antigen in chronic carriers dose not necessarily imply a good prognosis. Hepatology 1998; 28:231-236.
7. McMahon BJ: Chronic carriers of hepatitis B virus who clear hepatitis B surface antigen: Are they really "Off the hook". Hepatology 1998; 28:265-267.
8. Shiratori Y, Shiina S, Imamura M, et al: Characteristic difference of hepatocellular carcinoma between hepatitis B and C viral infection in Japan. Hepatology 1995; 22:1027-1033.
9. Miyagawa S, Kawasaki S, Makuuchi M: Comparison of the characteristics of hepatocellular carcinoma between hepatitis B and C viral infection: tumor multicentricity in cirrhotic liver with hepatitis C. Hepatology 1996; 11:944-948.
10. Sato A, Kato Y, Nakata K, et al: Relationship between sustained elevation of serum alanine aminotransferase and progression from cirrhosis to hepatocellular carcinoma: comparison in patients with hepatitis B virus- and hepatitis C virus associated cirrhosis. J Gastroenterol Hepatol 1996; 11:944-948.
11. Shuto T, Hirohashi K, Kubo S, et al: Difference of resected hepatocellular carcinoma with hepatitis B or C virus. Hepatogastroenterology 1998; 45:1722-1725.
12. Okoshi S, Igarashi M, Suda T, Iwamatsu H, Watanabe K, Ishihara K, Ogata N, Nomoto M, Takahashi T, Ichida T, Asakura H, Nihei K, Kurosaki I: Remote development of hepatocellular carcinoma in patients with liver cirrhosis type B serologically cured for HBs antigenemia with long-standing normalization of ALT values. Dig Dis Sci 2002 47:2002-2006.
13. Scheuer PJ: Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 1991; 13:372-374.
14. Fujiyama A, Miyanohara A, Nozaki C, Yoneyama T, Ohtomo N, Matsubara K: Cloning and structural analysis of hepatitis B virus DNAs, subtype adr. Nucleic Acids Res 1982; 11:4601-4609.
15. Katsuro K, Kobayashi M, Gondo M, Hayashi I, Osuga T, Takada S: Hepatitis B virus DNA is frequently found in liver biopsy samples from hepatitis C virus-infected chronic hepatitis patients. J Med Virol 1998; 54:249-255.
16. Shiratori Y, Imazeki F, Moriyama M, Yano M, Arakawa Y, Yokosuka O, Kuroki T, Nishiguchi S, Sata M, Yamada G, Fujiyama S, Yoshida H, Omata M: Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy. Ann Int Med 2000; 132:517-524.