In vivo confocal fluorescence imaging of skin surface cellular morphology: A pilot study of its potential as a clinical tool in skin research

International Journal of Cosmetic Science

Volumn 28, Issue 1, 2006, Pages 9-20

  Leeson, Daan Thorn ^a   Meyers, C Lynn ^a   Subramanyan, K ^a  

^a UNILEVER RESEARCH   (United Kingdom)

Author keywords

Clinical methods; Confocal microscopy; Fluorescence; Skin imaging

Indexed keywords

CONTRAST MEDIUM; FLUORESCENT DYE; GLYCEROL;

ADULT; AGED; ARTICLE; CELL STRUCTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DESQUAMATION; FEMALE; FLUORESCENCE MICROSCOPY; HUMAN; IMAGING SYSTEM; IN VIVO STUDY; MAJOR CLINICAL STUDY; PILOT STUDY; SKIN SURFACE; STRATUM CORNEUM; THREE DIMENSIONAL IMAGING; XEROSIS;

EID: 33344458244     PISSN: 01425463     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1467-2494.2006.00292.x     Document Type: Article

References (9)

1. Rajadhyaksha, M., Gonzalez, S., Zavislan, J.M. et al. In vivo confocal scanning laser microscopy of human skin. II. Advances in instrumentation and comparison with histology. J. Invest. Dermatol. 113, 293-303 (1999).
2. Corcuff, P., Chaussepied, C., Madry, G. et al. Skin optics revisited by in vivo confocal microscopy, melanin and sun exposure. J. Cosmet. Sci. 52, 91-102 (2001).
3. Thorn Leeson, D., Meyers, C.L., Subramanyan K. In vivo confocal fluorescence imaging of skin surface cellular morphology [abstract]. OSA Biomedical Topical Meeting Technical Digest, Optical Society of America. Washington, D.C., PD8-1 (2002).
4. Swindle, L.D., Thomas, S.G., Freeman, M. et al. View of normal human skin in vivo as observed using fluorescent fiber-optic confocal microscopic imaging. J. Invest. Dermatol. 121, 706-712 (2003).
5. Thau, P. Glycerin (glycerol): current insights into the functional properties of a classic cosmetic raw material. J. Cosmet. Sci. 53, 229-236 (2002).
6. Bissett, D.L. Skin conditioning with glycerol. J. Soc. Cosmet. Chem. 35, 345-350 (1984).
7. Rawlings, A., Harding, C. and Watkinson, A. The effect of glycerol and humidity on desmosome degradation in stratum corneum. Arch. Dermatol. Res. 287, 457-464 (1995).
8. Watkinson, A., Harding, C., Moore, A. et al. Water modulation of stratum corneum chymotryptic enzyme activity and desquamation. Arch. Dermatol. Res. 293, 470-476 (2001).
9. Rawlings, A.V., Scott, I.R., Harding, C.R. et al. Stratum corneum moisturization at the molecular level. J. Invest. Dermatol. 103, 731-740 (1994).