Effect of sugar concentration on camptothecin production in cell suspension cultures of Camptotheca acuminata

Biotechnology and Bioprocess Engineering

Volumn 4, Issue 4, 1999, Pages 277-280

  Kim, Sung Hye ^a   Hur, Byung Ki ^b   Byun, Sang Yo ^a  

^a Ajou University   (South Korea)

^b Inha University   (South Korea)

Author keywords

Camptotheca acuminata; Camptothecin; Sucrose effect

Indexed keywords

EID: 33244488884     PISSN: 12268372     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02933753     Document Type: Article

References (17)

1. Wall, M. E., M. C. Wani, C. E. Cook, K. H. Palmer, A. T. McPhail, and G. A. Sim (1966) Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J. Am. Chem. Soc. 88: 3888-3890.
2. Hsiang, Y.-H. and L. F. Liu (1988) Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res. 48: 1722-1726.
3. Hsiang, Y.-H., L. F. Liu, M. E. Wall, M. C. Wani, A. W. Nicholas, G. Manikumar, S. Kirschenbaum, S. Silver, and M. Potmesil (1989) DNA topoisomerase I-mediated DNA clevage and cytotoxicity of camptothecin analogue. Cancer Res. 49: 4385-4398.
4. Jaxel, C., K. W. Kohn, M. C. Wani, M. E. Wall, and Y. Pommier (1989) Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to tumor activity. Cancer Res. 49: 1465-1469.
5. Zihou, M., H. Malak, and T. G. Burke (1995) Reduced albumin binding promotes the stability and activity of topotecan in human blood. Biochemistry 34: 13722-13728.
6. Suzuki, A. and M. Kato (1996) Chemotherapeutic agent CPT-11 induces the new expression of the apoptosis initiator to the cytoplasm. Exp. Cell Res. 227: 154-159.
7. McNeil, C. (1996) Topotecan: After FDA and ASCO, what's next? J. Nat. Cancer Inst. 88: 788-789.
8. Wall, M. E. and M. C. Wani (1995) Camptothecin and taxol: Discovery to clinic. Cancer Res. 55: 753-760.
9. Sakato, K., H. Tanaka, N. Mukui, and M. Misawa (1974) Isolation and identification of camptothecin from cells of Camptotheca acuminata suspension cultures. Agric. Biol. Chem. 38: 217-218.
10. Sakato, K. and M. Misawa (1974) Effects of chemical and physical conditions on growth of Camptotheca acuminata cell cultures. Agric. Biol. Chem. 38: 491-497.
11. Hengel, A. J., M. P. Harkes, H. J. Wichers, P. G. M. Hesselink, and R. M. Buitelaar (1992) Characterization of callus and camptothecin production by cell lines of Camptotheca acuminata, Plant Cell Tiss. Org. Cult. 28: 11-18.
12. Song, S. H. and S. Y. Byun (1998) Characterization of Cell Growth and Camptothecin Production in Cell Cultures of Camptotheca acuminata. J. Microbiol. Biotechnol. 8: 631-638.
13. Fujita, Y., Y. Hara, T. Ogrio and C. Suga (1981) Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon. Plant Cell Rep. 1: 59.
14. Rajendran, L., G. A. Ravishankar, L. V. Venkataraman, and K. R. Pranthiba (1992) Anthocyanin production in callus cultures of Daucus carota as influenced by nutrient stress and osmoticum. Biotechnol. Lett. 14: 707-712.
15. Park, I.-S., J.-H. Kim, J.-H. Youn, S. Y. Byun, and D.-I. Kim (1995) Production of taxol and related taxanes in Taxus brevifolia cell cultures: effect of sugar. Biotechnol. Lett. 17: 101-106.
16. Park, I.-S. and D.-I. Kim (1993) Significance of fresh weight to dry cell weight ratio in plant suspension cultures. Biotechnol. Tech. 7: 626-630.
17. Panda, A. K., S. Mishira, and V. S. Bisaria (1992) Alkaloid production by plant cell suspension cultures of Holarrhena antidysenterica: I. Effect of major nutrients. Biotechnol. Bioeng. 39: 1043-1051.