Stereoselective alkylation of [2-(diphenylphosphino)ferrocenyl]acetonitrile

Inorganic Chemistry Communications

Volumn 9, Issue 3, 2006, Pages 319-321

  Lamač, Martin ^a   Štěpnička, Petr ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Alkylation; Chiral donors; Ferrocene; Nitriles; Structure elucidation

Indexed keywords

EID: 33144486271     PISSN: 13877003     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.inoche.2005.12.003     Document Type: Article

References (17)

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10. 4, and evaporated under reduced pressure. The crude product was immediately purified by column chromatography (silica gel, diethyl ether) to give 2a as an orange oil, that solidified at 4°C. Yield: 125 mg (62%). NMR analysis revealed the product to be a mixture of two diastereoisomers in a molar ratio of 15:1. Recrystallization from aqueous acetic acid afforded pure major diastereoisomer as an orange crystalline solid.
11. 4, and pre-adsorbed onto silica gel by co-evaporation. The solid material was transferred onto the top of a chromatographic column (silica gel, hexane-ether 10:1) and eluted with the same solvent mixture. A subsequent evaporation yielded diphosphine 2b as a single diastereoisomer. Yield: 200 mg (67%), viscous orange oil.
12. 3): δ -24.6 (s).
13. 2: 593.1125, found 593.1102.
14. -3) should be regarded as true positive residual electron density). Geometric calculations were performed with Platon program [11c]. CCDC Deposition No.: 288346. References: A. Altomare, M.C. Burla, M. Camalli, G.L. Cascarano, C. Giacovazzo, A. Guagliardi, A.G.G. Moliterni, G. Polidori, and R. Spagna J. Appl. Crystallogr. 32 1999 115
15. G.M. Sheldrick SHELXL97. Program for the Refinement of Crystal Structures 1997 University of Goettingen Germany
16. Platon - A Multipurpose Crystallographic Tool. Available from: http://www.cryst.chem.uu.nl/platon/.
17. P. Štěpnička Eur. J. Inorg. Chem. 2005 3787