Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 7, 2006, Pages 1954-1956

  Lee, Jinho ^a   Kim, Jonghyun ^b   Koh, Jong Sung ^b   Chung, Hyun Ho ^b   Kim, Kyoung Hee ^b  

^a Keimyung University   (South Korea)

^b LG Chemical Ltd   (South Korea)

Author keywords

1,3,5,5 Tetrasubstituted 2,4 imidazolinedione; Farnesyl transferase; Hydantoin; Non peptidic

Indexed keywords

HYDANTOIN DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN;

ARTICLE; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50;

CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HYDANTOINS; ONCOGENE PROTEIN P21(RAS);

EID: 33144484035     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.12.074     Document Type: Article

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17. 3H]FPP into H-Ras protein by 50%
18. 3) 1.79 (p, 2H), 2.64 (t, J = 7.3 Hz, 2H), 3.56 (br, 1H), 3.60 (t, J = 6.1 Hz, 2H), 6.69 (s, 1H), 7.48 (s, 1H).
19. 3): 1.97 (p, 2H), 3.57 (t, J = 5.8 Hz, 2H), 4.06 (br, 1H), 4.11 (t, J = 6.7 Hz, 2H), 6.92 (s, 1H), 7.01 (s, 1H), 7.51 (s, 1H).
20. The coordinate has been deposited in the Protein Data Bank: PDB ID 2F0Y.