Synthesis and antifungal activity of 6-hydroxycinnolines

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 7, 2006, Pages 1850-1853

  Ryu, Chung Kyu ^a   Lee, Jung Yoon ^a  

^a Ewha Womans University   (South Korea)

Author keywords

6 Hydroxycinnoline; Antifungal; Antimicrobial compounds; Fungi; Substitution effects

Indexed keywords

1,4 CYCLOHEXADIENE; ANTIFUNGAL AGENT; CINNOLINE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS; CANDIDA; DRUG POTENCY; DRUG SYNTHESIS;

ANTIFUNGAL AGENTS; ASPERGILLUS; CANDIDA; HETEROCYCLIC COMPOUNDS, 2-RING; MOLECULAR STRUCTURE;

ASPERGILLUS; CANDIDA; FUNGI;

EID: 33144458814     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.005     Document Type: Article

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10. 1H NMR spectra were recorded on a Varian Unity INOVA 400 MHz FT-NMR spectrometer with TMS. High-resolution mass spectra (HRMS EI) were taken with Jeol JMS AX505 WA. 2,3-Dimethylbenzene-1,4- diol (3) and other reagents were purchased from Aldrich Chemical Co.
11. 3).
12. 4: 267.0299. Found: 267.0298.
13. General procedure for synthesis of methyl-2-cyano-2-(-2-arylthio-4,5- dimethyl-3,6-dioxocyclohexa-1,4-dienyl)acetates. 6a-e: arylthiol (0.448 mmol) was added to the solution of compound 5 (120 mg, 0.448 mmol) in 100 mL of 95% EtOH and the mixture was stirred at rt or refluxed for 4-5 h. The oily products were purified by silica gel column chromatography.
14. 3S: 369.1147. Found: 369.1149.
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