Synthesis and preliminary biological evaluation of the 99mTc labeled nitrobenzoimidazole and nitrotriazole as tumor hypoxia markers

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 7, 2006, Pages 1831-1833

  Zhang, Yu ^a   Chu, Taiwei ^a   Gao, Xuguang ^a   Liu, Xinqi ^a   Yang, Zhi ^b   Guo, Zhenquan ^c   Wang, Xiangyun ^a  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

^c PEKING UNIVERSITY   (China)

Author keywords

Hypoxia; Labeling; Nitrobenzoimidazole; Nitrotriazole; Tumor

Indexed keywords

1 (3 1,2,4 NITROTRIAZOLE 1 YL)PROPANHYDROXYIMINOAMIDE TC 99M; 1 (6 NITROBENZOIMIDAZOLE 1 YL)PROPANHYDROXYIMINOAMIDE TC 99M; IMIDAZOLE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; TRACER; TRIAZOLE DERIVATIVE; TUMOR MARKER; UNCLASSIFIED DRUG;

AEROBIC CELL CULTURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG DISTRIBUTION; ISOTOPE LABELING; MOUSE; NONHUMAN; TUMOR LOCALIZATION;

AMIDES; ANIMALS; CELL LINE, TUMOR; IMIDAZOLES; MICE; ORGANOTECHNETIUM COMPOUNDS; PROPANOLS; TRIAZOLES; TUMOR MARKERS, BIOLOGICAL;

ANIMALIA; MURINAE;

EID: 33144455593     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.001     Document Type: Article

References (13)

1. A. Nunn, K. Linder, and H.W. Strauss Eur. J. Nucl. Med. 22 1995 265
2. V.T. Kagiya, S. Nishmoto, T. Ito, J. Wang, M. Abe, and K. Sasai Int. J. Radiat. Oncol. Biol. Phys. 22 1992 601
3. A.M. Rauth, T. Melo, and V. Misra Int. J. Radiat. Oncol. Biol. Phys. 42 1998 755
4. R.P. Gupta, C.A. Larroquette, and K.C. Agrawal J. Med. Chem. 25 1982 1342
5. S. Murugesan, S.J. Shetty, O.P.D. Noronha, A.M. Samuel, T.S. Srivastava, C.K.K. Nair, and L. Kothari Appl. Radiat. Isot. 54 2001 81
6. T.W. Chu, S.W. Hu, B. Wei, Y. Wang, X.Q. Liu, and X.Y. Wang Bioorgan. Med. Chem. Lett. 14 2004 747
7. T.W. Chu, R.J. Li, S.W. Hu, X.Q. Liu, and X.Y. Wang Nucl. Med. Biol. 31 2004 199
8. 3 were: C, 48.19; N, 28.10; H, 4.45. Found: C, 48.42; N, 28.03; H, 4.24.
9. A.M. Efros J. Gen. Chem. USSR. (Engl. Transl) 30 1960 3533
10. F. Tileman Ber 17 1884 126
11. M. Nakayama, H. Saigo, A. Koda, K. Ozeki, K. Harada, A. Sugii, S. Tomiguchi, A. Kojima, M. Hara, R. Nakashima, Y. Ohyama, M. Takahashi, J. Takata, and Y. Karube Appl. Radiat. Isot. 6 1994 735
12. J.R. Ballinger, J.W.M. Kee, and A.M. Rauth J. Nucl. Med. 37 1996 1023
13. T. Melo, J. Duncan, J.R. Ballinger, and A.M. Rauth J. Nucl. Med. 41 2000 169