Wound healing and nitric oxide production: Too little or too much may impair healing and cause chronic wounds

International Journal of Lower Extremity Wounds

Volumn 5, Issue 1, 2006, Pages 6-8

  Schulz, Greg ^a   Stechmiller, Joyce ^b  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF NURSING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DOXYCYCLINE; HYDROXYPROLINE; INDUCIBLE NITRIC OXIDE SYNTHASE; MATRIX METALLOPROTEINASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; SCLEROPROTEIN;

CELL MIGRATION; CHRONIC WOUND; CLINICAL TRIAL; DIABETES MELLITUS; DIET SUPPLEMENTATION; EDITORIAL; EPITHELIUM CELL; HEMOSTASIS; HUMAN; MALNUTRITION; NONHUMAN; PRIORITY JOURNAL; SKIN INJURY; THROMBOCYTE AGGREGATION; WOUND CARE; WOUND HEALING;

ANIMALS; CHRONIC DISEASE; HUMANS; NITRIC OXIDE; SKIN; WOUND HEALING;

EID: 32944472614     PISSN: 15347346     EISSN: None     Source Type: Journal    
DOI: 10.1177/1534734606286633     Document Type: Editorial

References (11)

1. Mast BA, Schultz GS. Interactions of cytokines, growth factors, and proteases in acute and chronic wounds. Wound Repair Regen 1996 ; 4: 411-420.
2. Schultz GS, Sibbald RG, Falanga V, et al. Wound bed preparation: a systematic approach to wound management. Wound Repair Regen 2003 ; 11 (Suppl 1). S1 - S28.
3. Albina JE, Mills CD, Henry WL Jr, Caldwell MD. Temporal expression of different pathways of 1-arginine metabolism in healing wounds. J Immunol 1990 ; 144: 3877-3880.
4. Shearer JD, Richards JR, Mills CD, Caldwell MD. Differential regulation of macrophage arginine metabolism: a proposed role in wound healing. Am J Physiol 1997 ; 272: E181 - E190.
5. Hurson M, Regan MC, Kirk SJ, Wasserkrug HL, Barbul A. Metabolic effects of arginine in a healthy elderly population. J Parenter Enteral Nutr 1995 ; 19: 227-230.
6. Kirk SJ, Hurson M, Regan MC, Holt DR, Wasserkrug HL, Barbul A. Arginine stimulates wound healing and immune function in elderly human beings. Surgery 1993 ; 114: 155-159.
7. Schwentker A, Vodovotz Y, Weller R, Billiar TR. Nitric oxide and wound repair: role of cytokines? Nitric Oxide 2002 ; 7: 1-10.
8. Schwentker A, Billiar TR. Inducible nitric oxide synthase: from cloning to therapeutic applications. World J Surg 2002 ; 26: 772-778.
9. Arbss MA, Ferrando JM, Vidal J, et al. Early effects of exogenous arginine after the implantation of prosthetic material into the rat abdominal wall. Life Sci 2000 ; 67: 2493-2512.
10. Schaffer MR, Tantry U, van Wesep RA, Barbul A. Nitric oxide metabolism in wounds. J Surg Res 1997 ; 71: 25-31.
11. Jude EB, Boulton AJ, Ferguson MW, Appleton I. The role of nitric oxide synthase isoforms and arginase in the pathogenesis of diabetic foot ulcers: possible modulatory effects by transforming growth factor beta 1. Diabetologia 1999 ; 42: 748-757.