Dexamethasone in the treatment of obstetric cholestasis: A case series

Journal of Obstetrics and Gynaecology

Volumn 26, Issue 2, 2006, Pages 110-114

  Diac, M ^a   Kenyon, A ^b   Nelson Piercy, C ^a,b   Girling, J ^c   Cheng, F ^a   Tribe, R M ^b   Goodman, J ^d   Shennan, A ^b   Williamson, C ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c WEST MIDDLESEX UNIVERSITY HOSPITAL   (United Kingdom)

^d MAIDSTONE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; URSODEOXYCHOLIC ACID;

ARTICLE; ASIAN; BIOCHEMISTRY; CAUCASIAN; CHOLESTASIS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFICACY; DRUG SAFETY; DRUG TREATMENT FAILURE; ETHNIC DIFFERENCE; FEMALE; FETUS; HUMAN; HYPERGLYCEMIA; OBSTETRIC CHOLESTASIS; PRIORITY JOURNAL; SYMPTOMATOLOGY; TREATMENT RESPONSE;

ANTI-INFLAMMATORY AGENTS; CHOLAGOGUES AND CHOLERETICS; CHOLESTASIS; DEXAMETHASONE; FEMALE; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS; TREATMENT OUTCOME; URSODEOXYCHOLIC ACID;

EID: 32944469799     PISSN: 01443615     EISSN: None     Source Type: Journal    
DOI: 10.1080/01443610500443246     Document Type: Article

References (26)

1. Abedin P, Weaver JB, Egginton E. 1999. Intrahepatic cholestasis of pregnancy: prevalence and ethnic distribution. Ethnicity and Health 4:35-37.
2. Bacq Y, Myara A, Brechot MC, Haman C, Studer E, Trivin F et al. 1995. Serum conjugated bile acid profile during intrahepatic cholestasis of pregnancy. Journal of Hepatology 22:66-70.
3. Bloom SL, Sheffield JS, McIntire DD, Leveno KJ. 2001. Antenatal dexamethasone and decreased birth weight. Obstetrics and Gynecology 97:485-490.
4. Burrows RF, Clavisi O, Burrows E. 2002. Interventions for treating cholestasis in pregnancy (Cochrane review). The Cochrane Library. Issue 4. Oxford: Update Software.
5. Crowley P. 2002. Prophylactic corticosteroids for preterm birth (Cochrane review). The Cochrane Library. Issue 2. Oxford: Update Software.
6. Davies MH, Ngong JM, Yucesoy M, Acharya SK, Mills CO, Weaver JB et al. 1994. The adverse influence of pregnancy upon sulphation: a clue to the pathogenesis of intrahepatic cholestasis of pregnancy? Journal of Hepatology 21:1127-1134.
7. Eleoranta MJ, Heinonen S, Mononen T, Saavikoski S. 2001. Risk of obstetric cholestasis in the sisters of index patients. Clinical Genetics 60:42-45.
8. Fisk NM, Storey GN. 1988. Fetal outcome in obstetric cholestasis. British Journal of Obstetrics and Gynaecology 95:1137-1143.
9. Girling JC, Dow E, Smith JH. 1997. Liver function tests in preeclampsia: importance of comparison with a reference range derived for normal pregnancy. British Journal of Obstetrics and Gynaecology 104:246-250.
10. Gorelik J, Shevchuk A, Diakonov I, de Swiet M, Lab M, Korchev Y et al. 2003. Dexamethasone and ursodeoxycholic acid protect against the arrhythmogenic effect of taurocholate in an in vitro study of rat cardiomyocytes. British Journal of Obstetrics and Gynaecology 110:467-474.
11. Hirvioja ML, Tuimala R, Vuori J. 1992. The treatment of intrahepatic cholestasis of pregnancy by dexamethasone. British Journal of Obstetrics and Gynaecology 99:109-111.
12. Jenkins JK, Boothby LA, Guzman-Santos WM, Edouard B. 2002. Treatment of itching associated with intrahepatic cholestasis of pregnancy. Annals of Pharmacotherapy 36:1462-1465.
13. Kauppila A, Tuimala R, Ylikorkala O, Reinila M, Ylostalo P. 1979. Placental steroid synthesis from DHEAS during dexamethasone therapy. Obstetrics and Gynaecology 54:39-41.
14. Kay HH, Bird IM, Coe CL, Dudley DJ. 2000. Antenatal steroid treatment and adverse fetal effects: what is the evidence? Journal of the Society for Gynecologic Investigation 7:269-278.
15. Kenyon AP, Nelson-Piercy C, Girling J, Williamson C, Tribe RM. Shennan AH. 2002. Obstetric cholestasis, outcome with active management: a series of 70 cases. British Journal of Obstetrics and Gynaecology 109:282-288.
16. Kretowicz E, McIntyre HD. 1994. Intrahepatic cholestasis of pregnancy, worsening after dexamethasone. Australia and New Zealand Journal of Obstetrics and Gynaecology 34:211-213.
17. Lammert F, Marschall HU, Glantz A, Matern S. 2000. Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management. Journal of Hepatology 33:1012-1021.
18. Lindberg MC. 1992. Hepatobiliary complications of oral contraceptives. Journal of General Internal Medicine 7:199-209.
19. Meng LJ, Reyes H, Palma J, Hernandez I, Ribalta J, Sjavall J. 1997. Effects of ursodeoxycholic acid on conjugated bile acids and progesterone metabolites in serum and urine of patients with intrahepatic cholestasis of pregnancy. Journal of Hepatology 27:1029-1040.
20. Modi N, Lewis H, Al-Naqeeb N, Ajayi-Obe M, Dore CJ, Rutherford M. 2001. The effects of repeated antenatal corticosteroid therapy on the developing brain. Pediatric Research 50:581-585.
21. Reyes H, Gonzales MC, Ribalta J, Aburto H, Matus C, Schramm G et al. 1978. Prevalence of intrahepatic cholestasis in Chile. Annals of Internal Medicine 88:487-493.
22. Rioseco AJ, Ivankovic MB, Manzur A, Hamed F, Kato SR, Parer JT et al. 1994. Intrahepatic cholestasis of pregnancy: a retrospective case-control study of perinatal outcome. American Journal of Obstetrics and Gynaecology 170:890-895.
23. Simmer HH, Frankland M, Greipel M. 1975. On the regulation of fetal and maternal 16-a-hydroxydehydroepiandrosterone and its sulphates by cortisol and ACTH in human pregnancy at term. American Journal of Obstetrics and Gynaecology 121:646-652.
24. Siiteri PK, MacDonald PC. 1966. Placental oestrogen biosynthesis during human pregnancy. Journal of Clinical Endocrinology and Metabolism 26:751-761.
25. Williamson C. 2001. Gastrointestinal disease. In: Nelson-Piercy C, editor. Drugs in pregnancy. Best Practice & Research. Clinical Obstetrics and Gynaecology. 15:937-952.
26. Williamson C, Gorelik J, Eaton BM, Lab M, de Swiet M. Korchev Y. 2001. The bile acid taurocholate impairs rat cardiomyocyte function: a proposed mechanism for intra-uterine fetal death in obstetric cholestasis. Clinical Science 100:363-369.