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Volumn 6, Issue 3, 2005, Pages 206-215

The evolving role of aromatase inhibitors in adjuvant breast cancer therapy

Author keywords

Anastrozole; Clinical trials; Exemestane; Letrozole; Tamoxifen

Indexed keywords

ANASTROZOLE; AROMATASE INHIBITOR; ESTROGEN; EXEMESTANE; LETROZOLE; MEGESTROL ACETATE; PLACEBO; TAMOXIFEN; ANTINEOPLASTIC AGENT; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR;

EID: 32944460981     PISSN: 15268209     EISSN: None     Source Type: Journal    
DOI: 10.3816/CBC.2005.n.022     Document Type: Review
Times cited : (6)

References (53)
  • 1
    • 0002478350 scopus 로고    scopus 로고
    • Malignant tumors of the breast
    • DeVita VT, Hellman S, Rosenberg SA, et al, eds, 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins;
    • Winer WC, Morrow M, Osborne CK. Malignant tumors of the breast. In DeVita VT, Hellman S, Rosenberg SA, et al, eds. Cancer. Principles and Practice of Oncology, 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2001:1651-1726.
    • (2001) Cancer. Principles and Practice of Oncology , pp. 1651-1726
    • Winer, W.C.1    Morrow, M.2    Osborne, C.K.3
  • 2
    • 0001481751 scopus 로고    scopus 로고
    • Epidemiology and non-genetic causes of breast cancer
    • eds, 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins;
    • Willett WC, Rockhill B, Hankinson SE, et al. Epidemiology and non-genetic causes of breast cancer. In: Harris JR, Lippman ME, Morrow M, et al, eds. Diseases of the Breast, 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2000:175-220.
    • (2000) Diseases of the Breast , pp. 175-220
    • Willett, W.C.1    Rockhill, B.2    Hankinson, S.E.3
  • 3
    • 0032569831 scopus 로고    scopus 로고
    • Tamoxifen in the treatment of breast cancer
    • Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med 1998; 339:1609-1618.
    • (1998) N Engl J Med , vol.339 , pp. 1609-1618
    • Osborne, C.K.1
  • 4
    • 0032537396 scopus 로고    scopus 로고
    • Tamoxifen for early breast cancer: An overview of the randomized trials
    • Early Breast Cancer Trialists' Group
    • Early Breast Cancer Trialists' Group. Tamoxifen for early breast cancer: an overview of the randomized trials. Lancet 1998; 351:1451-1467.
    • (1998) Lancet , vol.351 , pp. 1451-1467
  • 5
    • 0000821032 scopus 로고    scopus 로고
    • Chemoprevention
    • Harris JR, Lippman ME, Morrow M, et al, eds, 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins;
    • Jordan VC, Costa, AF. Chemoprevention. In: Harris JR, Lippman ME, Morrow M, et al, eds. Diseases of the Breast, 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2000:265-279.
    • (2000) Diseases of the Breast , pp. 265-279
    • Jordan, V.C.1    Costa, A.F.2
  • 6
    • 2142652244 scopus 로고    scopus 로고
    • Therapeutic targeting in the estrogen receptor hormonal pathway
    • Katzenellenbogen BS, Frasor J. Therapeutic targeting in the estrogen receptor hormonal pathway. Semin Oncol 2004; 31(suppl 3):28-38.
    • (2004) Semin Oncol , vol.31 , Issue.SUPPL. 3 , pp. 28-38
    • Katzenellenbogen, B.S.1    Frasor, J.2
  • 7
    • 2942652871 scopus 로고    scopus 로고
    • Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
    • Shou J, Massarweh S, Osborne CK, et al. Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J Natl Cancer Inst 2004; 96:926-935.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 926-935
    • Shou, J.1    Massarweh, S.2    Osborne, C.K.3
  • 8
    • 0038210242 scopus 로고    scopus 로고
    • Aromatase inhibitors in breast cancer
    • Smith IE, Dowsett M. Aromatase inhibitors in breast cancer. N Engl J Med 2003; 348:2431-2442.
    • (2003) N Engl J Med , vol.348 , pp. 2431-2442
    • Smith, I.E.1    Dowsett, M.2
  • 9
    • 1842505162 scopus 로고    scopus 로고
    • Aromatase inhibitors for breast cancer in postmenopausal women
    • Campos SM. Aromatase inhibitors for breast cancer in postmenopausal women. Oncologist 2004; 9:126-136.
    • (2004) Oncologist , vol.9 , pp. 126-136
    • Campos, S.M.1
  • 10
    • 0037157603 scopus 로고    scopus 로고
    • Baum M, Buzdar AU, Cuzick J, et al. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. ATAC Trialists' Group [published erratum in Lancet 2002; 360:1520]. Lancet 2002; 359:2131-2139.
    • Baum M, Buzdar AU, Cuzick J, et al. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. ATAC Trialists' Group [published erratum in Lancet 2002; 360:1520]. Lancet 2002; 359:2131-2139.
  • 11
    • 7444259675 scopus 로고    scopus 로고
    • A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer
    • Goss PE, Ingle JN, Martino S, et al. A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer. N Engl J Med 2003; 349:1793-1802.
    • (2003) N Engl J Med , vol.349 , pp. 1793-1802
    • Goss, P.E.1    Ingle, J.N.2    Martino, S.3
  • 12
    • 10744223655 scopus 로고    scopus 로고
    • Coombes RC, Hall E, Gibson LJ, et al. A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer. Intergroup Exemastane Study [published erratum in N Engl J Med 2004; 351:2461]. N Engl J Med 2004; 350:1081-1092.
    • Coombes RC, Hall E, Gibson LJ, et al. A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer. Intergroup Exemastane Study [published erratum in N Engl J Med 2004; 351:2461]. N Engl J Med 2004; 350:1081-1092.
  • 13
    • 0029903614 scopus 로고    scopus 로고
    • Randomized trial of two versus five years of adjuvant tamoxifen for postmenopausal early stage breast cancer
    • Swedish Breast Cancer Cooperative Group
    • Swedish Breast Cancer Cooperative Group. Randomized trial of two versus five years of adjuvant tamoxifen for postmenopausal early stage breast cancer. J Natl Cancer Inst 1996; 88:1543-1549.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1543-1549
  • 14
    • 8044243594 scopus 로고    scopus 로고
    • Preliminary results from the Cancer Research Campaign trial evaluating tamoxifen duration in women aged fifty years or older with breast cancer
    • Current Trials Working Party of the Cancer Research Campaign Breast Cancer Trials Group
    • Current Trials Working Party of the Cancer Research Campaign Breast Cancer Trials Group. Preliminary results from the Cancer Research Campaign trial evaluating tamoxifen duration in women aged fifty years or older with breast cancer. J Natl Cancer Inst 1996; 88:1834-1839.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1834-1839
  • 15
    • 0030055509 scopus 로고    scopus 로고
    • Randomised comparison of 5 years adjuvant tamoxifen with continuous therapy for operable breast cancer. the Scottish Cancer Trials Breast Group
    • Stewart HJ, Forrest AP, Everington D, et al. Randomised comparison of 5 years adjuvant tamoxifen with continuous therapy for operable breast cancer. the Scottish Cancer Trials Breast Group. Br J Cancer 1996; 74:297-299.
    • (1996) Br J Cancer , vol.74 , pp. 297-299
    • Stewart, H.J.1    Forrest, A.P.2    Everington, D.3
  • 16
    • 0030479062 scopus 로고    scopus 로고
    • Postchemotherapy adjuvant tamoxifen therapy beyond five years in patients with lymph node-positive breast cancer. Eastern Cooperative Oncology Group
    • Tormey D, Gray R, Falkson H. Postchemotherapy adjuvant tamoxifen therapy beyond five years in patients with lymph node-positive breast cancer. Eastern Cooperative Oncology Group. J Natl Cancer Inst 1996; 88:1828-1833.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1828-1833
    • Tormey, D.1    Gray, R.2    Falkson, H.3
  • 17
    • 10344238569 scopus 로고    scopus 로고
    • Five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors
    • Fisher B, Dignam J, Bryant J, et al. Five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors. J Natl Cancer Inst 1996; 88:1529-1542.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1529-1542
    • Fisher, B.1    Dignam, J.2    Bryant, J.3
  • 18
    • 0035795683 scopus 로고    scopus 로고
    • Five versus more than five years of tamoxifen therapy for lymph node-negative breast cancer: Updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial
    • Fisher B, Dignam J, Bryant J, et al. Five versus more than five years of tamoxifen therapy for lymph node-negative breast cancer: updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial. J Natl Cancer Inst 2001; 93:684-690.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 684-690
    • Fisher, B.1    Dignam, J.2    Bryant, J.3
  • 19
    • 84898696200 scopus 로고    scopus 로고
    • National Cancer Research Network Trials Portfolio, Available at:, Accessed July 6, 2004
    • National Cancer Research Network Trials Portfolio. NCRN web site. Available at: http://www.ncrn.org.uk/portfolio/data.asp. Accessed July 6, 2004.
    • NCRN web site
  • 20
    • 0032537990 scopus 로고    scopus 로고
    • Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 study
    • Fisher B, Constantino JR Wickerham DL, et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 study. J Natl Cancer Inst 1998; 90:1371-1388.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1371-1388
    • Fisher, B.1    Constantino, J.R.2    Wickerham, D.L.3
  • 21
    • 0032848782 scopus 로고    scopus 로고
    • Health-related quality of life and tamoxifen in breast cancer prevention: A report from the National Surgical Adjuvant Breast Bowel Project P-1 study
    • Day R, Ganz PA, Constantino JP, et al. Health-related quality of life and tamoxifen in breast cancer prevention: a report from the National Surgical Adjuvant Breast Bowel Project P-1 study. J Clin Oncol 1999; 17:2659-2669.
    • (1999) J Clin Oncol , vol.17 , pp. 2659-2669
    • Day, R.1    Ganz, P.A.2    Constantino, J.P.3
  • 22
    • 0033520748 scopus 로고    scopus 로고
    • Gail MH, Costantino JP, Bryant J, et al. Weighing the risks and benefits of tamoxifen treatment for preventing breast cancer [published erratum in J Natl Cancer Inst 2000; 92:275]. J Natl Cancer Inst 1999; 91:1829-1846.
    • Gail MH, Costantino JP, Bryant J, et al. Weighing the risks and benefits of tamoxifen treatment for preventing breast cancer [published erratum in J Natl Cancer Inst 2000; 92:275]. J Natl Cancer Inst 1999; 91:1829-1846.
  • 23
    • 0028246412 scopus 로고
    • The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth
    • Osborne CK, Jarman M, McCague R, et al. The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth. Cancer Chemother Pharmacol 1994; 34:89-95.
    • (1994) Cancer Chemother Pharmacol , vol.34 , pp. 89-95
    • Osborne, C.K.1    Jarman, M.2    McCague, R.3
  • 24
    • 0345604400 scopus 로고    scopus 로고
    • Apoptotic action of 17beta-estradiol in raloxifene-resistant MCF-7 cells in vitro and in vivo
    • Liu H, Lee ES, Gajdos C, et al. Apoptotic action of 17beta-estradiol in raloxifene-resistant MCF-7 cells in vitro and in vivo. J Natl Cancer Inst 2003; 95:1586-1597.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1586-1597
    • Liu, H.1    Lee, E.S.2    Gajdos, C.3
  • 25
    • 9144262303 scopus 로고    scopus 로고
    • Come SE, Buzdar AU, Arteaga CL, et al. Proceedings of the Third International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statement. Clin Cancer Res 2004; 10(1 pt 2):327s-330s.
    • Come SE, Buzdar AU, Arteaga CL, et al. Proceedings of the Third International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statement. Clin Cancer Res 2004; 10(1 pt 2):327s-330s.
  • 26
    • 0027074588 scopus 로고
    • Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu
    • Benz CC, Scott GK, Sarup JC, et al. Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu. Breast Cancer Res Treat 1993; 24:85-95.
    • (1993) Breast Cancer Res Treat , vol.24 , pp. 85-95
    • Benz, C.C.1    Scott, G.K.2    Sarup, J.C.3
  • 27
    • 0029662337 scopus 로고    scopus 로고
    • C-erb B2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastases
    • Carlomagno C, Perrone F, Gallo C, et al. C-erb B2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastases. J Clin Oncol 1996; 14:2702-2708.
    • (1996) J Clin Oncol , vol.14 , pp. 2702-2708
    • Carlomagno, C.1    Perrone, F.2    Gallo, C.3
  • 28
    • 0030757466 scopus 로고    scopus 로고
    • Prediction of response to antiestrogen therapy in advanced breast cancer patients by pretreatment circulating levels of extracellular domain of the HER-2/c-neu protein
    • Yamauchi H, O'Neill A, Gelman R, et al. Prediction of response to antiestrogen therapy in advanced breast cancer patients by pretreatment circulating levels of extracellular domain of the HER-2/c-neu protein. J Clin Oncol 1997; 15:2518-2525.
    • (1997) J Clin Oncol , vol.15 , pp. 2518-2525
    • Yamauchi, H.1    O'Neill, A.2    Gelman, R.3
  • 29
    • 0003236118 scopus 로고    scopus 로고
    • Elevated serum HER-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer
    • Abstract
    • Lipton A, Ali SM, Leitzel K, et al. Elevated serum HER-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer. Proc Am Soc Clin Oncol 2000; 19:71a (Abstract #274).
    • (2000) Proc Am Soc Clin Oncol , vol.19 , Issue.274
    • Lipton, A.1    Ali, S.M.2    Leitzel, K.3
  • 30
    • 0035871525 scopus 로고    scopus 로고
    • When is a tumor marker ready for prime time? A case study of c-erbB-2 as a predictive factor in breast cancer
    • Yamauchi H, Stearns V, Hayes DF. When is a tumor marker ready for prime time? A case study of c-erbB-2 as a predictive factor in breast cancer. J Clin Oncol 2001; 19:2334-2356.
    • (2001) J Clin Oncol , vol.19 , pp. 2334-2356
    • Yamauchi, H.1    Stearns, V.2    Hayes, D.F.3
  • 31
    • 0037341399 scopus 로고    scopus 로고
    • Twenty-year results of the Naples GUN randomized trial: Predictive factors of adjuvant tamoxifen efficacy in early breast cancer
    • De Placido S, De Laurentiis M, Carlomagno C, et al. Twenty-year results of the Naples GUN randomized trial: predictive factors of adjuvant tamoxifen efficacy in early breast cancer. Clin Cancer Res 2003; 9:1039-1046.
    • (2003) Clin Cancer Res , vol.9 , pp. 1039-1046
    • De Placido, S.1    De Laurentiis, M.2    Carlomagno, C.3
  • 32
    • 0035884620 scopus 로고    scopus 로고
    • Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1 and/or ErbB-2-positive primary breast cancer: Evidence from a phase III randomized trial
    • Ellis MJ, Coop A, Singh B, et al. Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1 and/or ErbB-2-positive primary breast cancer: evidence from a phase III randomized trial. J Clin Oncol 2001; 19:3808-3816.
    • (2001) J Clin Oncol , vol.19 , pp. 3808-3816
    • Ellis, M.J.1    Coop, A.2    Singh, B.3
  • 33
    • 1842863554 scopus 로고    scopus 로고
    • Comparison of anastrozole vs. tamoxifen alone in combination as neoadjuvant treatment of estrogen receptor-positive (ER+) operable breast cancer in postmenopausal women: The IMPACT trial
    • Abstract
    • Smith I, Dowsett M. Comparison of anastrozole vs. tamoxifen alone in combination as neoadjuvant treatment of estrogen receptor-positive (ER+) operable breast cancer in postmenopausal women: the IMPACT trial. San Antonio Breast Cancer Symposium 2003; (Abstract #1).
    • (2003) San Antonio Breast Cancer Symposium , Issue.1
    • Smith, I.1    Dowsett, M.2
  • 34
    • 12144273720 scopus 로고    scopus 로고
    • Smith IE, for the IMPACT trialists. Molecular effects of anastrozole (A) and tamoxifen (T) alone and combined (C) in the IMPACT trial of neoadjuvant treatment of primary breast cancer
    • Abstract
    • Dowsett M, Smith IE, for the IMPACT trialists. Molecular effects of anastrozole (A) and tamoxifen (T) alone and combined (C) in the IMPACT trial of neoadjuvant treatment of primary breast cancer. Proc Am Soc Clin Oncol 2004; 23:11 (Abstract #537).
    • (2004) Proc Am Soc Clin Oncol , vol.23 , Issue.537 , pp. 11
    • Dowsett, M.1
  • 35
    • 3042545132 scopus 로고    scopus 로고
    • Aromatase inhibitors in breast cancer
    • Lonning PE. Aromatase inhibitors in breast cancer. Endocr Relat Cancer 2004; 11:179-189.
    • (2004) Endocr Relat Cancer , vol.11 , pp. 179-189
    • Lonning, P.E.1
  • 36
    • 0024474020 scopus 로고
    • Aromatase inhibitors in the treatment of advanced breast cancer
    • Miller WR. Aromatase inhibitors in the treatment of advanced breast cancer. Cancer Treat Rev 1989; 16:83-93.
    • (1989) Cancer Treat Rev , vol.16 , pp. 83-93
    • Miller, W.R.1
  • 37
    • 0029804714 scopus 로고    scopus 로고
    • Influence of anastrozole (Arimidex), a selective, non-steroidal aromastase inhibitor, on in vivo aromatisation and plasma oestrogen levels in postmenopausal women with breast cancer
    • Geisler J, King N, Dowsett M, et al. Influence of anastrozole (Arimidex), a selective, non-steroidal aromastase inhibitor, on in vivo aromatisation and plasma oestrogen levels in postmenopausal women with breast cancer. Br J Cancer 1996;74:1286-1291.
    • (1996) Br J Cancer , vol.74 , pp. 1286-1291
    • Geisler, J.1    King, N.2    Dowsett, M.3
  • 38
    • 0036467847 scopus 로고    scopus 로고
    • Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, crossover study
    • Geisler J, Haynes B, Anker G, et al. Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, crossover study. J Clin Oncol 2002; 20:751-757.
    • (2002) J Clin Oncol , vol.20 , pp. 751-757
    • Geisler, J.1    Haynes, B.2    Anker, G.3
  • 39
    • 0029560237 scopus 로고
    • In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in postmenopausal patients with breast cancer
    • Dowsett M, Jones A, Johnston SR, et al. In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in postmenopausal patients with breast cancer. Clin Cancer Res 1995; 1:1511-1515.
    • (1995) Clin Cancer Res , vol.1 , pp. 1511-1515
    • Dowsett, M.1    Jones, A.2    Johnston, S.R.3
  • 40
    • 0031663593 scopus 로고    scopus 로고
    • In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients
    • Geisler J, King N, Anker G, et al. In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients. Clin Cancer Res 1998; 4:2089-2093.
    • (1998) Clin Cancer Res , vol.4 , pp. 2089-2093
    • Geisler, J.1    King, N.2    Anker, G.3
  • 41
    • 0034669435 scopus 로고    scopus 로고
    • Anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in 668 postmenopausal women: Results of the Tamoxifen or Arimidex Randomized Group Efficacy and Tolerability study
    • Bonneterre J, Thurlimann B, Robertson JF, et al. Anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in 668 postmenopausal women: results of the Tamoxifen or Arimidex Randomized Group Efficacy and Tolerability study. J Clin Oncol 2000; 18:3748-3757.
    • (2000) J Clin Oncol , vol.18 , pp. 3748-3757
    • Bonneterre, J.1    Thurlimann, B.2    Robertson, J.F.3
  • 42
    • 0034669484 scopus 로고    scopus 로고
    • Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: Results of a North American multicenter randomized trial
    • Nabholtz JM, Buzdar A, Pollak M, et al. Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial. J Clin Oncol 2000; 18:3758-3767.
    • (2000) J Clin Oncol , vol.18 , pp. 3758-3767
    • Nabholtz, J.M.1    Buzdar, A.2    Pollak, M.3
  • 43
    • 85030506571 scopus 로고    scopus 로고
    • Dirix L, Piccart MJ, Lohrish C, et al. Efficacy and tolerance to exemestane (E) versus tamoxifen (T) in 1st line hormone therapy (HT) of postmenopausal metastatic breast cancer (MBC) patients (pts): a European Organisation for the Research and Treatment of Cancer (EORTC Breast Group) phase II trial with Pharmacia and Upjohn. Proc Am Soc Clin Oncol 2001; 20:29a (Abstract #114).
    • Dirix L, Piccart MJ, Lohrish C, et al. Efficacy and tolerance to exemestane (E) versus tamoxifen (T) in 1st line hormone therapy (HT) of postmenopausal metastatic breast cancer (MBC) patients (pts): a European Organisation for the Research and Treatment of Cancer (EORTC Breast Group) phase II trial with Pharmacia and Upjohn. Proc Am Soc Clin Oncol 2001; 20:29a (Abstract #114).
  • 44
    • 0343584508 scopus 로고    scopus 로고
    • Mouridsen H, Gershanovich M, Sun Y, et al. Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group [published erratum in J Clin Oncol 2001; 19:3302]. J Clin Oncol 2001; 19:2596-2606.
    • Mouridsen H, Gershanovich M, Sun Y, et al. Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group [published erratum in J Clin Oncol 2001; 19:3302]. J Clin Oncol 2001; 19:2596-2606.
  • 45
    • 0035498544 scopus 로고    scopus 로고
    • Anastrozole is superior to tamoxifen as first-line therapy in hormone receptor positive advanced breast carcinoma
    • Bonneterre J, Buzdar A, Nabholtz JM, et al. Anastrozole is superior to tamoxifen as first-line therapy in hormone receptor positive advanced breast carcinoma. Cancer 2001; 92:2247-2258.
    • (2001) Cancer , vol.92 , pp. 2247-2258
    • Bonneterre, J.1    Buzdar, A.2    Nabholtz, J.M.3
  • 46
    • 85030510300 scopus 로고    scopus 로고
    • Paridaens R, Therasse L, Dirix L, et al. First line hormonal treatment (HT) for metastatic breast cancer (MBC) with exemestane (E) or tamoxifen (T) in postmenopausal patients (pts): a randomized phase III trial of the EORTC Breast Group. Proc Am Soc Clin Oncol 2004; 23:6 (Abstract #515).
    • Paridaens R, Therasse L, Dirix L, et al. First line hormonal treatment (HT) for metastatic breast cancer (MBC) with exemestane (E) or tamoxifen (T) in postmenopausal patients (pts): a randomized phase III trial of the EORTC Breast Group. Proc Am Soc Clin Oncol 2004; 23:6 (Abstract #515).
  • 47
    • 0142181118 scopus 로고    scopus 로고
    • Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: Results of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial efficacy and safety update analyses. ATAC Clinical Trialists' Group
    • Baum M, Buzdar A, Cuzick J, et al. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: results of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial efficacy and safety update analyses. ATAC Clinical Trialists' Group. Cancer 2003; 98:1802-1810.
    • (2003) Cancer , vol.98 , pp. 1802-1810
    • Baum, M.1    Buzdar, A.2    Cuzick, J.3
  • 48
    • 84898692895 scopus 로고    scopus 로고
    • Dowsett M, on behalf of the ATAC Clinical Trialists' Group. Analysis of time to recurrence in the ATAC (arimidex, tamoxifen, alone or in combination) trial according to estrogen receptor and progesterone receptor status. Breast Cancer Res Treat 2003; (Abstract #4).
    • Dowsett M, on behalf of the ATAC Clinical Trialists' Group. Analysis of time to recurrence in the ATAC (arimidex, tamoxifen, alone or in combination) trial according to estrogen receptor and progesterone receptor status. Breast Cancer Res Treat 2003; (Abstract #4).
  • 49
    • 84898697947 scopus 로고    scopus 로고
    • Howell A, on behalf of the ATAC Trialists Group. ATAC ('Arimidex', tamoxifen, alone or in combination) completed treatment analysis: anastrozole demonstrates superior efficacy and tolerability compared with tamoxifen. San Antonio Breast Cancer Symposium 2004; (Abstract #1).
    • Howell A, on behalf of the ATAC Trialists Group. ATAC ('Arimidex', tamoxifen, alone or in combination) completed treatment analysis: anastrozole demonstrates superior efficacy and tolerability compared with tamoxifen. San Antonio Breast Cancer Symposium 2004; (Abstract #1).
  • 50
    • 5444234822 scopus 로고    scopus 로고
    • Updated analysis of the NCIC CTG MA.17 randomized placebo (P) controlled trial of letrozole (L) after five years of tamoxifen in postmenopausal women wity early stage breast cancer
    • Abstract
    • Goss PE, Ingle JN, Martino S, et al. Updated analysis of the NCIC CTG MA.17 randomized placebo (P) controlled trial of letrozole (L) after five years of tamoxifen in postmenopausal women wity early stage breast cancer. Proc Am Soc Clin Oncol 2004; 22: 14S (Abstract #847).
    • (2004) Proc Am Soc Clin Oncol , vol.22 , Issue.847
    • Goss, P.E.1    Ingle, J.N.2    Martino, S.3
  • 51
    • 84898689206 scopus 로고    scopus 로고
    • Collaborative Group. Letrozole vs. tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor-positive breast cancer. Presented at the 9th International Conference on Primary Therapy of Early Breast Cance;, January 26, 2005. Available at: press kit/presentation. Accessed March 4, 2005
    • Thurlimann B, for the BIG 1-98 Collaborative Group. Letrozole vs. tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor-positive breast cancer. Presented at the 9th International Conference on Primary Therapy of Early Breast Cance;, January 26, 2005. Available at: www.ibcsg.org/BIG 1-98 press kit/presentation. Accessed March 4, 2005.
    • Thurlimann B, for the BIG 1-98
  • 52
    • 85030501555 scopus 로고    scopus 로고
    • Jakesz R, Kaufmann M, Gnant M, et al, on behalf of the ABCSG, the GABG. Benefits of switching postmenopausal women with hormone-sensitive early breast cancer to anastrozole after 2 years adjuvant tamoxifen: combined results from 3,123 women enrolled in the ABCSG trial 8 and the ARNO 95 trial. Presented at the San Antonio Breast Cancer Symposium, December 2004. Available at: www.sabcs.org/symposiumonline/index.asp. Accessed March 4, 2005.
    • Jakesz R, Kaufmann M, Gnant M, et al, on behalf of the ABCSG, the GABG. Benefits of switching postmenopausal women with hormone-sensitive early breast cancer to anastrozole after 2 years adjuvant tamoxifen: combined results from 3,123 women enrolled in the ABCSG trial 8 and the ARNO 95 trial. Presented at the San Antonio Breast Cancer Symposium, December 2004. Available at: www.sabcs.org/symposiumonline/index.asp. Accessed March 4, 2005.
  • 53
    • 0029759541 scopus 로고    scopus 로고
    • Annual hazard rates of recurrence for breast cancer after primary therapy
    • Saphner T, Tormey DC, Gray R. Annual hazard rates of recurrence for breast cancer after primary therapy. J Clin Oncol 1996; 14:2738-2746.
    • (1996) J Clin Oncol , vol.14 , pp. 2738-2746
    • Saphner, T.1    Tormey, D.C.2    Gray, R.3


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