Lack of association of catechol-O-methyltransferase gene Val108/158Met polymorphism with schizophrenia: A family-based association study in a Chinese population [1]

Molecular Psychiatry

Volumn 11, Issue 1, 2006, Pages 2-3

  Tsai, S J ^a,b   Hong, C J ^a,b   Hou, S J ^c   Yen, F C ^c  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c CHENG HSIN REHABILITATION MEDICAL CENTER   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CATHECOL O METHYLTRANSFERASE; METHYLTRANSFERASE; UNCLASSIFIED DRUG;

CAUCASIAN; CHINESE; CORRELATION ANALYSIS; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HOSPITAL PATIENT; HUMAN; INTERVIEW; LETTER; MEDICAL RECORD; MENTAL PATIENT; PARENT; POPULATION; PRIORITY JOURNAL; PSYCHIATRIST; RISK FACTOR; SCHIZOPHRENIA;

ASIAN CONTINENTAL ANCESTRY GROUP; CATECHOL O-METHYLTRANSFERASE; FAMILY HEALTH; HUMANS; POLYMORPHISM, GENETIC; SCHIZOPHRENIA;

EID: 32844471040     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/sj.mp.4001736     Document Type: Letter

References (10)

1. Lewis CM et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet 2003; 73: 34-48.
2. Lotta T et al. Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 1995; 34: 4202-4210.
3. Munafo MR et al. Lack of association of the COMT (Val(158/108) Met) gene and schizophrenia: a meta-analysis of case-control studies. Mol Psychiatry 2005; 10: 765-770.
4. Glatt SJ et al. Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies. Am J Psychiatry 2003; 160: 469-476.
5. Li T et al. Preferential transmission of the high activity allele of COMT in schizophrenia. Psychiatr Genet 1996; 6: 131-133.
6. Fan JB et al. Family-based association studies of COMT gene polymorphisms and schizophrenia in the Chinese population. Mol Psychiatry 2002; 7: 446-447.
7. Tsai SJ et al. Association study of a functional catechol-O- methyltransferase genetic polymorphism with age of onset, cognitive function, symptomatology and prognosis in chronic schizophrenia. Neuropsychobiology 2004; 49: 196-200.
8. Bray NJ et al. A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Am J Hum Genet 2003; 73: 152-161.
9. Zhu G et al. Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5′ nuclease assay. Psychopharmacology 2004; 177: 178-184.
10. Shifman S et al. A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet 2002; 71: 1296-1302.