Chromosomal mapping of hyperserum IgA and glomerular IgA deposition in a high IgA (HIGA) strain of DdY mice

Kidney International

Volumn 68, Issue 6, 2005, Pages 2517-2525

  Nogaki, Fumiaki ^b   Oida, Emi ^b   Kamata, Tadashi ^b   Kobayashi, Ikei ^b   Nomura, Keiko ^b   Suyama, Katsuo ^b   Tahara, Sachiko ^b   Ono, Takahiko ^b   Miyawaki, Shigeki ^b   Serikawa, Tadao ^b   Yoshida, Haruyoshi ^b   Kita, Toru ^b   Muso, Eri ^a  

^a Kitano Hospital   (Japan)

^b NONE

Author keywords

HIGA mice; IgA nephropathy; Quantitative trait loci

Indexed keywords

IMMUNOGLOBULIN A;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CHROMOSOME 1; CHROMOSOME 15; CHROMOSOME 2; CHROMOSOME 4; CHROMOSOME MAP; COMPUTER PROGRAM; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE LOCUS; GENETIC MARKER; GLOMERULONEPHRITIS; GLOMERULUS; MICROSATELLITE MARKER; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; STATISTICAL SIGNIFICANCE;

ANIMALS; CHROMOSOME MAPPING; FEMALE; GLOMERULONEPHRITIS, IGA; IMMUNOGLOBULIN A; KIDNEY GLOMERULUS; MICE; MICE, INBRED BALB C; MICE, MUTANT STRAINS; MICROSATELLITE REPEATS; QUANTITATIVE TRAIT LOCI; SPECIES SPECIFICITY;

EID: 32844466827     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2005.00659.x     Document Type: Article

References (26)

1. WOODROFFE AJ, GORMLY AA, MCKENZIE PE, et al: Immunologic studies in IgA nephropathy. Kidney Int 18:366-374, 1980
2. MONTEIRO RC, HALBWACHS-MECARELLI L, ROQUE-BARREIRA MC, et al: Charge and size of mesangial IgA in IgA nephropathy. Kidney Int 28:666-671, 1985
3. MESTECKY J, TOMANA M, CROWLEY-NOWICK PA, et al: Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy. Contrib Nephrol 104:172-182, 1993
4. CASANUEVA B, RODRIGUEZ-VALVERDE V, ARIAS M, et al: Immunoglobulin- producing cells in IgA nephropathy. Nephron 43:33-37, 1986
5. VAN-DEN-WALL-BAKE AW, DAHA MR, VAN-DER-ARK A, et al: Serum levels and in vitro production of IgA subclasses in patients with primary IgA nephropathy. Clin Exp Immunol 74:115-120, 1988
6. SANCHO J, EGIDO J, RIVERA F, HERNANDO L: Immune complexes in IgA nephropathy: Presence of antibodies against diet antigens and delayed clearance of specific polymeric IgA immune complexes. Clin Exp Immunol 54:194-202, 1983
7. LAI KN, HO RT, LEUNG JC, et al: Increased mRNA encoding for transforming factor-beta in CD4+ cells from patients with IgA nephropathy. Kidney Int 46:862-868, 1994
8. DE-FIJTER JW, DAHA MR, SCHROEIJERS WE, et al: Increased IL-10 production by stimulated whole blood cultures in primary IgA nephropathy. Clin Exp Immunol 111:429-434, 1998
9. HIKI Y, KOKUBO T, IWASE H, et al: Underglycosylation of IgA1 hinge plays a certain role for its glomerular deposition in IgA nephropathy. J Am Soc Nephrol 10:760-769, 1999
10. SANO T, HIKI Y, KOKUBO T, et al: Enzymatically deglycosylated human IgA1 molecules accumulate and induce inflammatory cell reaction in rat glomeruli. Nephrol Dial Transplant 17:50-56, 2002
11. JULIAN BA, QUIGGINS PA, THOMPSON JS, et al: Familial IgA nephropathy. Evidence of an inherited mechanism of disease. N Engl J Med 312:202-208, 1985
12. JULIAN BA, WOODFORD SY, BAEHLER RW, et al: Familial clustering and immunogenetic aspects of IgA nephropathy. Am J Kidney Dis 12:366-370, 1988
13. SCHENA F-P, CERULLO G, ROSSINI M, et al: Increased risk of end-stage renal disease in familial IgA nephropathy. J Am Soc Nephrol 13:453-460, 2002
14. GHARAVI AG, YAN Y, SCOLARI F, et al: IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23. Nat Genet 26:354-357, 2000
15. IMAI H, NAKAMOTO Y, ASAKURA K, et al: Spontaneous glomerular IgA deposition in ddY mice: An animal model of IgA nephritis. Kidney Int 27:756-761, 1985
16. MUSO E, YOSHIDA H, TAKEUCHI E, et al: Enhanced production of glomerular extracellular matrix in a new mouse strain of high serum IgA ddY mice. Kidney Int 50:1946-1957, 1996
17. MIYAWAKI S, MUSO E, TAKEUCHI E, et al: Selective breeding for high serum IgA levels from noninbred ddY mice: Isolation of a strain with an early onset of glomerular IgA deposition. Nephron 76:201-207, 1997
18. KAMATA T, NOGAKI F, FAGARASAN S, et al: Increased frequency of surface IgA-positive plasma cells in the intestinal lamina propria and decreased IgA excretion in hyper IgA (HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA. J Immunol 165:1387-1394, 2000
19. OYAMA A, MUSO E, ONO T, et al: Up-regulated TGF-beta mRNA expression in splenic T cells of high IgA-prone mice: a murine model of IgA nephropathy with glomerulosclerosis. Nephron 88:368-375, 2001
20. NOGAKI F, MUSO E, KOBAYASHI I, et al: Interleukin 12 induces crescentic glomerular lesions in a high IgA strain of ddY mice, independently of changes in IgA deposition. Nephrol Dial Transplant 15:1146-1154, 2000
21. KOBAYASHI I, NOGAKI F, KUSANO H, et al: Interleukin-12 alters the physicochemical characteristics of serum and glomerular IgA and modifies glycosylation in a ddY mouse strain having high IgA levels. Nephrol Dial Transplant 17:2108-2116., 2002
22. OIDA E, NOGAKI F, KOBAYASHI I, et al: Quantitative trait loci (QTL) analysis reveals a close linkage between the hinge region and trimeric IgA dominancy in a high IgA strain (HIGA) of ddY mice. Eur J Immunol 34:2200-2208, 2004
23. MANLY KF, CUDMORE RH, MEER JM: Map Manager QTX, cross-platform software for genetic mapping. Mamm Genome 12:930-932, 2001
24. LANDER E, KRUGLYAK L: Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247, 1995
25. KOKUBO T, HIKI Y, IWASE H, et al: Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins. J Am Soc Nephrol 9:2048-2054, 1998
26. NELSON JC: QGENE: software for marker-based genomic analysis and breeding. Mol Breeding 3:239-245, 1997