Cdx2 modulates proliferation in normal human intestinal epithelial crypt cells

Biochemical and Biophysical Research Communications

Volumn 342, Issue 1, 2006, Pages 66-72

  Escaffit, Fabrice ^a   Paré, Frédéric ^a   Gauthier, Rémy ^a   Rivard, Nathalie ^a   Boudreau, François ^a   Beaulieu, Jean François ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Cell differentiation; Cell proliferation; Intestinal cells; Transcription factors

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; TRANSCRIPTION FACTOR CDX2;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; HOMEOBOX; HUMAN; HUMAN CELL; INTESTINE CELL; INTESTINE CRYPT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANTIGENS, CD26; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; INTESTINES; OLIGO-1,6-GLUCOSIDASE; SUCROSE;

EID: 32644470090     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.01.128     Document Type: Article

References (37)

1. M.W. Babyatsky, and D.K. Podolsky Growth and development of the gastrointestinal tract T. Yamada Textbook of Gastroenterology 1999 J.B. Lippincott Philadelphia 547 584
2. D.C. Rubin Small intestine: anatomy and structural anomalies T. Yamada Textbook of Gastroenterology 1999 J.B. Lippincott Philadelphia 1561 1583
3. P. Duprey, K. Chowdhury, G.R. Dressler, R. Balling, D. Simon, J.L. Guenet, and P. Gruss A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine Genes Dev. 2 1988 1647 1654
4. R. James, and J. Kazenwadel Homeobox gene expression in the intestinal epithelium of adult mice J. Biol. Chem. 266 1991 3246 3251
5. R.K. Montgomery, A.E. Mulberg, and R.J. Grand Development of the human gastrointestinal tract: twenty years of progress Gastroenterology 116 1999 702 731
6. P.G. Traber Development of the brushborder enzyme activities I.R. Sanderson W.A. Walker Development of the Gastrointestinal Tract 2000 B.C. Decker Hamilton 103 122
7. F. Beck The role of Cdx genes in the mammalian gut Gut 53 2004 1394 1396
8. E. Suh, and P.G. Traber An intestine-specific homeobox gene regulates proliferation and differentiation Mol. Cell Biol. 16 1996 619 625
9. T. Hinoi, P.C. Lucas, R. Kuick, S. Hanash, K.R. Cho, and E.R. Fearon CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia Gastroenterology 123 2002 1565 1577
10. O. Lorentz, I. Duluc, A.D. Arcangelis, P. Simon-Assmann, M. Kedinger, and J.N. Freund Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation J. Cell Biol. 139 1997 1553 1565
11. T. Sakaguchi, X. Gu, H.M. Golden, E. Suh, D.B. Rhoads, and H.C. Reinecker Cloning of the human claudin-2 5′-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha J. Biol. Chem. 277 2002 21361 21370
12. C. Mitchelmore, J.T. Troelsen, N. Spodsberg, H. Sjostrom, and O. Noren Interaction between the homeodomain proteins Cdx2 and HNF1alpha mediates expression of the lactase-phlorizin hydrolase gene Biochem. J. 346 Pt. 2 2000 529 535
13. R. Fang, N.A. Santiago, L.C. Olds, and E. Sibley The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation Gastroenterology 118 2000 115 127
14. S.D. Krasinski, H.M. Van Wering, M.R. Tannemaat, and R.J. Grand Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha Am. J. Physiol. Gastrointest. Liver Physiol. 281 2001 G69 G84
15. F. Boudreau, E.H. Rings, H.M. van Wering, R.K. Kim, G.P. Swain, S.D. Krasinski, J. Moffett, R.J. Grand, E.R. Suh, and P.G. Traber Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene J. Biol. Chem. 277 2002 31909 31917
16. L.J. Staloch, J.K. Divine, J.T. Witten, and T.C. Simon C/EBP and Cdx family factors regulate liver fatty acid binding protein transgene expression in the small intestinal epithelium Biochim. Biophys. Acta 1731 2005 168 178
17. N. Perreault, and J.F. Beaulieu Use of the dissociating enzyme thermolysin to generate viable human normal intestinal epithelial cell cultures Exp. Cell Res. 224 1996 354 364
18. N. Desloges, N. Basora, N. Perreault, Y. Bouatrouss, D. Sheppard, and J.F. Beaulieu Regulated expression of the integrin alpha9beta1 in the epithelium of the developing human gut and in intestinal cell lines: relation with cell proliferation J. Cell Biochem. 71 1998 536 545
19. N. Basora, F.E. Herring-Gillam, F. Boudreau, N. Perreault, L.P. Pageot, M. Simoneau, Y. Bouatrouss, and J.F. Beaulieu Expression of functionally distinct variants of the beta(4)A integrin subunit in relation to the differentiation state in human intestinal cells J. Biol. Chem. 274 1999 29819 29825
20. L.P. Pageot, N. Perreault, N. Basora, C. Francoeur, P. Magny, and J.F. Beaulieu Human cell models to study small intestinal functions: recapitulation of the crypt-villus axis Microsc. Res. Tech. 49 2000 394 406
21. A. Quaroni, and J.F. Beaulieu Cell dynamics and differentiation of conditionally immortalized human intestinal epithelial cells Gastroenterology 113 1997 1198 1213
22. N. Perreault, and J.F. Beaulieu Primary cultures of fully differentiated and pure human intestinal epithelial cells Exp. Cell Res. 245 1998 34 42
23. F. Escaffit, F. Boudreau, and J.F. Beaulieu Differential expression of claudin-2 along the human intestine: implication of GATA-4 in the maintenance of claudin-2 in differentiating cells J. Cell Physiol. 203 2005 15 26
24. C. Deschenes, A. Vezina, J.F. Beaulieu, and N. Rivard Role of p27(Kip1) in human intestinal cell differentiation Gastroenterology 120 2001 423 438
25. J.F. Beaulieu, B. Nichols, and A. Quaroni Posttranslational regulation of sucrase-isomaltase expression in intestinal crypt and villus cells J. Biol. Chem. 264 1989 20000 20011
26. P.H. Vachon, and J.F. Beaulieu Extracellular heterotrimeric laminin promotes differentiation in human enterocytes Am. J. Physiol. 268 1995 G857 G867
27. M.W. Pfaffl, G.W. Horgan, and L. Dempfle Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR Nucleic Acids Res. 30 2002 e36
28. M.W. Pfaffl A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res. 29 2001 e45
29. A. Quaroni, J.Q. Tian, P. Seth, and C. Ap Rhys p27(Kip1) is an inducer of intestinal epithelial cell differentiation Am. J. Physiol. Cell Physiol. 279 2000 C1045 C1057
30. Y.Q. Bai, S. Miyake, T. Iwai, and Y. Yuasa CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene Oncogene 22 2003 7942 7949
31. R.J. Guo, E. Huang, T. Ezaki, N. Patel, K. Sinclair, J. Wu, P. Klein, E.R. Suh, and J.P. Lynch Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity J. Biol. Chem. 279 2004 36865 36875
32. M.S. Keller, T. Ezaki, R.J. Guo, and J.P. Lynch Cdx1 or Cdx2 expression activates E-cadherin-mediated cell-cell adhesion and compaction in human COLO 205 cells Am. J. Physiol. Gastrointest. Liver Physiol. 287 2004 G104 G114
33. J. Boulanger, A. Vezina, S. Mongrain, F. Boudreau, N. Perreault, B.A. Auclair, J. Laine, C. Asselin, and N. Rivard Cdk2-dependent phosphorylation of homeobox transcription factor CDX2 regulates its nuclear translocation and proteasome-mediated degradation in human intestinal epithelial cells J. Biol. Chem. 280 2005 18095 18107
34. C. Gespach Crosstalk between the cell cycle regulator Cdk2 and the Cdx2 tumor suppressor at the proliferation-differentiation interface Oncogene 24 2005 7953 7954
35. J. Lynch, M. Keller, R.J. Guo, D. Yang, and P. Traber Cdx1 inhibits the proliferation of human colon cancer cells by reducing cyclin D1 gene expression Oncogene 22 2003 6395 6407
36. E. van den Akker, S. Forlani, K. Chawengsaksophak, W. de Graaff, F. Beck, B.I. Meyer, and J. Deschamps Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation Development 129 2002 2181 2193
37. J.Q. Tian, and A. Quaroni Involvement of p21(WAF1/Cip1) and p27(Kip1) in intestinal epithelial cell differentiation Am. J. Physiol. 276 1999 C1245 C1258