Free amino acids in hearts of pediatric patients with congenital heart disease: The effects of cyanosis, age, and pathology

Annals of Thoracic Surgery

Volumn 81, Issue 3, 2006, Pages 943-949

  Modi, Paul ^a   Suleiman, M Saadeh ^a   Reeves, Barnaby C ^a   Pawade, Ash ^a   Parry, Andrew J ^a   Angelini, Gianni D ^a   Caputo, Massimo ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; ASPARTIC ACID; GLUTAMIC ACID; TAURINE;

ARTICLE; BIRTH; CONGENITAL HEART DISEASE; CONTROLLED STUDY; CYANOSIS; HEART MUSCLE BIOPSY; HEART MUSCLE ISCHEMIA; HEART SURGERY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MULTIPLE REGRESSION; PRESCHOOL CHILD; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

AGING; ALANINE; AMINO ACIDS; BIOPSY; CHILD; CHILD, PRESCHOOL; CYANOSIS; GLUTAMIC ACID; HEART DEFECTS, CONGENITAL; HEART VENTRICLES; HUMANS; INFANT; INFANT, NEWBORN; OXYGEN; REGRESSION ANALYSIS;

EID: 32644463907     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2005.08.071     Document Type: Article

References (30)

1. S. Matsuoka, J.M. Jarmakani, H.H. Young, S. Uemura, T. Nakanishi The effect of glutamate on hypoxic newborn rabbit heart J Mol Cell Cardiol 18 1986 897 906
2. M.T. Kronon, B.S. Allen, K.S. Bolling The role of cardioplegia induction temperature and amino acid enrichment in neonatal myocardial protection Ann Thorac Surg 70 2000 756 764
3. P. Julia, E.R. Kofsky, G.D. Buckberg, H.H. Young, H.I. Bugyi Studies of myocardial protection in the immature heart. I. Enhanced tolerance of immature versus adult myocardium to global ischemia with reference to metabolic differences J Thorac Cardiovasc Surg 100 1990 879 887
4. P. Julia, H. Young, G.D. Buckberg, E. Kofsky, H.I. Bugyi Studies of myocardial protection in the immature heart. II. Evidence for importance of amino acid metabolism in tolerance to ischemia J Thorac Cardiovasc Surg 100 1990 888 895
5. P. Modi, M.-S. Suleiman, B. Reeves Myocardial metabolic changes during pediatric cardiac surgery a randomized study of three cardioplegic techniques J Thorac Cardiovasc Surg 128 2004 67 75
6. H. Imura, M. Caputo, A. Parry, A. Pawade, G.D. Angelini, M.-S. Suleiman Age-dependent and hypoxia-related differences in myocardial protection during pediatric open-heart surgery Circulation 103 2001 1551 1556
7. P. Julia, E. Kofsky, G.D. Buckberg, H.H. Young, H. Bugyi Studies of myocardial protection in the immature heart. III. Models of ischemic and hypoxic/ischemic injury in the immature puppy heart J Thorac Cardiovasc Surg 101 1991 14 22
8. N.A. Silverman, J. Kohler, S. Levitsky, D.G. Pavel, R.B. Fang, H. Feinberg Chronic hypoxemia depresses global ventricular function and predisposes to the depletion of high-energy phosphates during cardioplegic arrest implications for surgical repair of cyanotic congenital heart defects Ann Thorac Surg 37 1984 304 308
9. P. Modi, M.-S. Suleiman, B.C. Reeves Basal metabolic state of hearts of patients with congenital heart disease the effects of cyanosis, age, and pathology Ann Thorac Surg 78 2004 1710 1716
10. M.-S. Suleiman, M. Caputo, R. Ascione Metabolic differences between hearts of patients with aortic valve disease and hearts of patients with ischaemic disease J Mol Cell Cardiol 30 1998 2519 2523
11. P. Modi, H. Imura, M. Caputo Cardiopulmonary bypass-induced myocardial reoxygenation injury in cyanotic pediatric patients J Thorac Cardiovasc Surg 124 2002 1035 1036
12. B. Safer The metabolic significance of the malate-aspartate cycle in heart Circ Res 37 1975 527 533
13. K.J. Peuhkurinen Regulation of the tricarboxylic acid cycle pool size in heart muscle J Mol Cell Cardiol 16 1984 487 495
14. N. King, J.D. McGivan, E.J. Griffiths, A.P. Halestrap, M.S. Suleiman Glutamate loading protects freshly isolated and perfused adult cardiomyocytes against intracellular ROS generation J Mol Cell Cardiol 35 2003 975 984
15. H. Taegtmeyer Metabolic responses to cardiac hypoxia increased production of succinate by rabbit papillary muscle Circ Res 43 1978 808 815
16. O.I. Pisarenko, I.M. Studneva, V. Khlopkov, E.S. Solomatina, E. Ruuge An assessment of anaerobic metabolism during ischemia and reperfusion in isolated guinea pig heart Biochim Biophys Acta 934 1988 55 63
17. M.F. Crass III, J.B. Lombardini Release of tissue taurine from the oxygen-deficient perfused rat heart Proc Soc Exp Biol Med 157 1978 486 488
18. H. Taegtmeyer, M.B. Peterson, V.V. Ragavan, A.G. Ferguson, M. Lesch De novo alanine synthesis in isolated oxygen-deprived rabbit myocardium J Biol Chem 252 1977 5010 5018
19. P. Modi, M.S. Suleiman Myocardial taurine, development and vulnerability to ischemia Amino Acids 26 2004 65 70
20. D.P. Taggart, L. Hadjinikolas, J. Hooper Effects of age and ischemic times on biochemical evidence of myocardial injury after pediatric cardiac operations J Thorac Cardiovasc Surg 113 1997 728 735
21. S.N. Allo, L. Bagby, S.W. Schaffer Taurine depletion, a novel mechanism for cardioprotection from regional ischemia Am J Physiol 273 pt 2 1997 H1956 H1961
22. J.H. Veerkamp, J.F. Glatz, A.J. Wagenmakers Metabolic changes during cardiac maturation Basic Res Cardiol 80 suppl 2 1985 111 113
23. B.H. Chua Specificity of leucine effect on protein degradation in perfused rat heart J Mol Cell Cardiol 26 1994 743 751
24. B. Chua, D.L. Siehl, H.E. Morgan Effect of leucine and metabolites of branched chain amino acids on protein turnover in heart J Biol Chem 254 1979 8358 8362
25. B.H. Chua, D.L. Siehl, H.E. Morgan A role for leucine in regulation of protein turnover in working rat hearts Am J Physiol 239 1980 E510 E514
26. E.F. Hildebrandt, D.B. Buxton, M.S. Olson Acute regulation of the branched-chain 2-oxo acid dehydrogenase complex by adrenaline and glucagon in the perfused rat heart Biochem J 250 1988 835 841
27. R.A. Harris, R. Kobayashi, T. Murakami, Y. Shimomura Regulation of branched-chain alpha-keto acid dehydrogenase kinase expression in rat liver J Nutr 131 2001 841S 845S
28. Y. Zhao, S.C. Denne, R.A. Harris Developmental pattern of branched-chain 2-oxo acid dehydrogenase complex in rat liver and heart Biochem J 290 pt 2 1993 395 399
29. E. Riva, D.J. Hearse The developing myocardium 1991 Futura Publishing Company, Inc New York
30. K. Bolling, M. Kronon, B.S. Allen, T. Wang, S. Ramon, H. Feinberg Myocardial protection in normal and hypoxically stressed neonatal hearts the superiority of blood versus crystalloid cardioplegia J Thorac Cardiovasc Surg 113 1997 994 1003