Plasmodium falciparum: The fungal metabolite gliotoxin inhibits proteasome proteolytic activity and exerts a plasmodicidal effect on P. falciparum

Experimental Parasitology

Volumn 112, Issue 3, 2006, Pages 179-183

  Hatabu, Toshimitsu ^a   Hagiwara, Masaki ^a   Taguchi, Nao ^a   Kiyozawa, Masayuki ^b   Suzuki, Mamoru ^a   Kano, Shigeyuki ^c   Sato, Kumiko ^a  

^a GUNMA UNIVERSITY   (Japan)

^b NISSAN CHEMICAL INDUSTRIES LTD   (Japan)

^c NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

Gliotoxin; GSH, reduced glutathione; GTX, gliotoxin; Plasmodium falciparum; pRBCs, parasitized red blood cells; Proteasome inhibitor; RBCs, red blood cells

Indexed keywords

GLIOTOXIN; GLUTATHIONE; PROTEASOME;

ANTIMALARIAL ACTIVITY; ARTICLE; CELL LEVEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; ERYTHROCYTE; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; LIVER CELL; NONHUMAN; PARASITE VIRULENCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANIMALS; ANTIMALARIALS; CELL LINE; CHLOROQUINE; CHYMOTRYPSIN; DRUG RESISTANCE; ERYTHROCYTES; GLIOTOXIN; GLUTATHIONE; HUMANS; INHIBITORY CONCENTRATION 50; LIVER; PLASMODIUM FALCIPARUM; PROTEASOME ENDOPEPTIDASE COMPLEX;

PLASMODIUM FALCIPARUM;

EID: 32644457083     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exppara.2005.11.012     Document Type: Article

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