Drug interaction between capecitabine and warfarin: A case report and review of the literature

International Journal of Clinical Pharmacology and Therapeutics

Volumn 44, Issue 2, 2006, Pages 80-82

  Yildirim, Yesim ^a   Ozyilkan, O ^a   Akcali, Z ^a   Basturk, B ^a  

^a BASKENT UNIVERSITY   (Turkey)

Author keywords

Capecitabine; Drug interaction; Warfarin

Indexed keywords

ANASTROZOLE; CAPECITABINE; CYCLOPHOSPHAMIDE; FLUOROURACIL; FRESH FROZEN PLASMA; METHOTREXATE; TAMOXIFEN; WARFARIN;

AGED; AORTA VALVE REGURGITATION; CASE REPORT; CONJUNCTIVAL HEMORRHAGE; DRUG DOSE REDUCTION; DRUG POTENTIATION; DRUG WITHDRAWAL; EPISTAXIS; FEMALE; HOSPITALIZATION; HUMAN; INTERNATIONAL NORMALIZED RATIO; PAGET NIPPLE DISEASE; REVIEW; THROMBOSIS;

EID: 32544450648     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP44080     Document Type: Review

References (11)

1. Aki Z, Kotiloglu G, Ozyilkan O 2000 A patient with prolong prothrombin time due to an adverse interaction between fluorouracil and warfarin. Am J Gasroenterol 95: 1093-1094
2. Blesch KS, Gieschke R, Tsukamoto Y, Reigner BG, Burger HU, Steimer JL 2003 Clinical pharmacokinetic/pharmacodynamic and physiologically based pharmacokinetic modeling in new drug development: the capecitabine experience. Invest New Drug 21: 195-223
3. Breckendridge AM 1978 Oral anticoagulant drugs: pharmacokinetic aspects. Semin Hematol 15: 19-26
4. Buyck HCE, Buckley N, Leslie MD, Plowmann PN 2003 Capecitabine induced potentiation of warfarin. Clin Oncol (R Coll Radiol) 15: 297
5. Camidge R, Reigner B, Cassidy J, Garnge S, Abt M, Weidekamm E et al 2005 Significant effect of capecitabine on the pharmacokinetics and pharmacodynamics of warfarin in patients with cancer. J Clin Oncol 21: 4719-4725
6. Copur MS, Ledakis P, Bolton M, Morse AK, Werner T, Norvell M et al 2001 An adverse interaction between warfarin and capecitabine: a case report and review of the literature. Clin Colorectal Cancer 1: 182-184
7. Hirsh J, Dalen JE, Anderson DR, Poller L, Bussey H, Ansell J et al 2001 Oral anticoagulants: mechanism of action, clinical effectiveness and optimal therapeutic range. Chest 119: 8-21
8. Isaacs K, Haim N 2005 Adverse interaction between capecitabine and warfarin in altered coagulation parameters and bleeding: case report and review of the literature. J Chemother 17: 339-342
9. Masci G, Magagnoli M, Zucali PA, Castagna L, Carnaghi C, Sarina B et al 2003 Minidose warfarin prophylaxis for catheter-associated thrombosis in cancer patients: can it be safely associated with fluorouracil-based chemotherapy? J Clin Oncol 21: 736-739
10. Naranjo CA, Busto U, Sellers EM, Sandor P, Roberts EA et al 1981 A method estimating the probability of adverse drug reactions. Clin Pharmacol Ther 30: 239-245
11. Zhou Q, Chan E 2002 Effect of fluorouracil on the anticoagulant activity and the pharmacokinetics of warfarin enantiomers in rats. Eur J Pharma Sci 17: 73-80