Discover a Drug Substance, Formulate and Develop it to a Product

The Practice of Medicinal Chemistry: Second Edition

Volumn , Issue , 2003, Pages 687-695

  Galli, Bruno ^a   Faller, Bernard ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; DRUG PRODUCTS; METABOLISM; PHYSIOLOGY;

ACTIVE TRANSPORT SYSTEMS; DRUG DISCOVERY PROCESS; EXPLORATORY RESEARCH; FORMULATION OPTIMIZATION; HIGH THROUGHPUT SCREENING; PHARMACOKINETIC PROPERTIES; RESEARCH DEVELOPMENT; THERAPEUTIC TARGETS;

LEAD COMPOUNDS;

EID: 32544435641     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012744481-9/50044-1     Document Type: Chapter

References (8)

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2. Amidon G., Lennernas H., Shah V.P., Crison J.R. Theoretical basis for a biopharmaceutical drug classification: correction of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 1995, 12:413-420.
3. Palm K., Stenberg P., Luthman K., Artursson P. Polar molecular surface properties predict intestinal absorption in humans. Pharm. Res. 1997, 14:568-571.
4. Seelig A., Gottschlich R., Devant R.M. A method to determine the ability of drugs to diffuse through the blood-brain barrier. Proc. Natl Acad. Sci. USA 1994, 91:68-72.
5. Arthusson P., et al. Correlation between oral absorption in humans and apparent drug permeability coefficient in human intestinal epithelial (CaCo-2) cells. Biophys. Res. Commun. 1991, 157:880-885.
6. Lipper R. E pluribus product. Mod. Drug Disc. 1999, 2:55-60.
7. Lesko L.J., Rowland M., Peck C.C., Blaschke T.F. Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans. Pharm. Res. 2000, 17:1335-1344.
8. Shillingford C.A., Vose C.W. Effective decision-making: progressing compounds through clinical development. Drug Disc. Today 2001, 6:941-946.