Mutagenic activity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Journal of Applied Genetics

Volumn 47, Issue 1, 2006, Pages 85-87

  Ulanowska, Katarzyna ^a   Wȩgrzyn, Grzegorz ^a,b  

^a UNIVERSITY OF GDA SK   (Poland)

^b INSTITUTE OF OCEANOLOGY   (Poland)

Author keywords

Methylxanthines; MPTP (1 methyl 4 phenyl 1,2,3,6 tetrahydropyridine); Mutagens; Vibrio harveyi mutagenicity assay

Indexed keywords

ANIMALIA; VIBRIO HARVEYI;

EID: 32544435620     PISSN: 12341983     EISSN: 12341983     Source Type: Journal    
DOI: 10.1007/BF03194604     Document Type: Article

References (14)

1. Cashman JR, 1987. Mutagenicity of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and its metabolites. Toxicology 43: 173-182.
2. Czyż A, Jasiecki J, Bogdan A, Szpilewska H, Wȩgrzyn G, 2000. Genetically modified Vibrio harveyi strains as potential bioindicators of mutagenic pollution of marine environments. Appl Environ Microbiol 66: 599-605.
3. Czyż A, Szpilewska H, Dutkiewicz R, Kowalska W, Biniewska-Godlewska A, Wȩgrzyn G, 2002. Comparison of the Ames test and a newly developed assay for detection of mutagenic pollution of marine environments. Mutat Res 519: 67-74.
4. Czyż A, Kowalska W, Wȩgrzyn G, 2003. Vibrio harveyi mutagenicity assay as a preliminary test for detection of mutagenic pollution of marine water. Bull Environ Contamin Toxicol 70: 1065-1070.
5. Klein G, Walczak R, Krasnowska E, Błaszczak A, Lipińska B, 1995. Characterization of heat-shock response of the marine bacterium Vibrio harveyi. Mol Microbiol 16: 801-811.
6. Maron DM, Ames BN, 1983. Revised methods for the Salmonella mutagenicity test. Mutat Res 113: 173-215.
7. Mortelmans K, Zeiger E, 2000. The Ames Salmonella/microsome mutagenicity assay. Mutat Res 455: 29-60.
8. Piosik J, Ulanowska K, Gwizdek-Wiśniewska A, Czyż A, Kapuściński J, Wȩgrzyn G, 2003. Alleviation of mutagenic effects of polycyclic aromatic agents (quinacrine mustard, ICR-191 and ICR-170) by caffeine and pentoxifylline. Mutat Res 530: 47-57.
9. Piosik J, Gwizdek-Wiśniewska A, Ulanowska K, Sochociński J, Czyż A, Wȩgrzyn G, 2005. Methylxanthines (caffeine, pentoxifylline and theophylline) decrease the mutagenic effect of daunomycin, doxorubicin andmitoxantrone. Acta Biochim Pol, in press.
10. Podgórska B, Chȩć E, Ulanowska K, Wȩgrzyn G, 2005. Optimisation of the microbiological mutagenicity assay based on genetically modified Vibrio harveyi strains. J Appl Gen 46: 241-246.
11. Singer TP, Ramsay RR, 1990. Mechanism of the neurotoxicity of MPTP. An update. FEES Lett 274: 1-8.
12. Speciale SG, 2002. MPTP. Insights into parkinsonian neurodegeneration. Neurotoxicol Teratol 24: 607-620.
13. Wȩgrzyn G, Czyż A, 2003. Detection of mutagenic pollution of natural environment using microbiological assays. J Appl Microbiol 95: 1175-1181.
14. Yang SC, Markey SP, Bankiewicz KS, London WT, Lunn G, 1988. Recommended safe practices for using the neurotoxin MPTP in animal experiments. Lab Anim Sci 38: 563-567.