Synthesis of analogs of the phenylamino-pyrimidine type protein kinase C inhibitor CGP 60474 utilizing a Negishi cross-coupling strategy

Tetrahedron

Volumn 62, Issue 10, 2006, Pages 2380-2387

  Stanetty, Peter ^a   Röhrling, Jürgen ^a   Schnürch, Michael ^a   Mihovilovic, Marko D ^a  

^a VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

Negishi cross coupling; Nucleophilic displacement; Phenylamino pyrimidines; Protein kinase inhibitors

Indexed keywords

2 (3 CHLOROANILINO) 4 [2 (3 HYDROXYPROPYLAMINO) 4 PYRIDYL]PYRIMIDINE; 2 CHLORO 4 (3 AMINOPHENYL)PYRIMIDINE; 2,2' DIFLUORO [4,4'] BIPYRIDINYL; 3 (2 FLUOROPYRIDIN 4 YL)PHENYLAMINE; 3 [3 (2 FLUOROPYRIDIN 4 YL)PHENYLAMINO]PROPANOL; 3 [3 [2 (3 CHLOROPHENYLAMINO)PYRIDIN 4 YL]PHENYLAMINO]PROPANOL; 3 [3 [2 (3 CHLOROPHENYLAMINO)PYRIMIDIN 4 YL]PHENYLAMINO]PROPANOL; 3 [[2' (3 CHLOROPHENYLAMINO) [4,4']BIPYRIDINYL 2 YL]AMINO]PROPANOL; 3 [[3 (2 CHLOROPYRIMIDIN 4 YL)PHENYL]AMINO] 3 OXOPROPANOIC ACID METHYL ESTER; 3 [[3 (2 FLUOROPYRIDIN 4 YL)PHENYL]AMINO] 3 OXOPROPANOIC ACID METHYL ESTER; 3 [[3 [2 (3 CHLOROPHENYLAMINO)PYRIMIDIN 4 YL]PHENYL]AMINO] 3 OXOPROPANOIC ACID METHYL ESTER; AMINE; AMINO ACID; N (3 BROMOPHENYL)CARBAMIC ACID 1,1 DIMETHYLETHYL ESTER; N (3 CHLOROPHENYL) 4 IODO 2 PYRIDINAMINE; N (3 CHLOROPHENYL) N (2' FLUORO [4,4'] BIPYRIDINYL 2 YL)AMINE; N (3 CHLOROPHENYL) N (2' FLUORO [4,4'] BIPYRIDINYL 2 YL)CARBAMIC ACID 1,1 DIMETHYLETHYL ESTER; N (3 CHLOROPHENYL) N (4 IODOPYRIDIN 2 YL)CARBAMIC ACID 1,1 DIMETHYLETHYL ESTER; N 2, N 4 BIS(3 CHLOROPHENYL)PYRIDIN 2,4 DIAMINE; N [3 (2 CHLOROPYRIMIDIN 4 YL)PHENYL]CARBAMIC ACID 1,1 DIMETHYLETHYL ESTER; N [3 (2 FLUOROPYRIDIN 4 YL)PHENYL]CARBAMIC ACID 1,1 DIMETHYLETHYL ESTER; N [3 (2 METHYLPYRIMIDIN 4 YL)PHENYL]CARBAMIC ACID 1,1 DIMETHYLETHYL ESTER; PALLADIUM; PROTEIN KINASE C INHIBITOR; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CROSS COUPLING REACTION; DEPROTECTION REACTION; DRUG SYNTHESIS; NEGISHI CROSS COUPLING; PRIORITY JOURNAL; QUANTUM YIELD; STRUCTURE ACTIVITY RELATION;

EID: 32444448757     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2005.11.067     Document Type: Article

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