The role of statistics in the success of a pharmaceutical research laboratory: A historical case description

Journal of Chemometrics

Volumn 19, Issue 5-7, 2005, Pages 282-287

  Lewi, Paul J ^a  

^a JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

History; Industry; Pharmaceutical; Research; Statistics

Indexed keywords

RESEARCH LABORATORIES;

CASE DESCRIPTION; DRIVING FORCES; HISTORICAL PERSPECTIVE; JANSSEN; OPEN MIND; PHARMACEUTICAL RESEARCH; SCIENTIFIC COMMUNITY; SCIENTIFIC ENTERPRISE; WORLD CLASS;

STATISTICS;

EID: 32444444361     PISSN: 08869383     EISSN: 1099128X     Source Type: Journal    
DOI: 10.1002/cem.930     Document Type: Conference Paper

References (19)

1. Achenwall G. The political constitution of the present principal European countries and peoples (in German). Schloezer AL, Sprengel MC, Goettingen D (eds). 1749.
2. Janssen PAJ. Drug Research. Rev. Méd. Brux. 1980; 1: 643-645.
3. Eddy NB, Leimbach D. Synthetic analgesics II. Dithienylbutenoyl and dithienylbutylamines. J. Pharmacol. Exp. Therap. 1953; 107: 385-389.
4. Janssen PAJ. The measurement of observed differences between treated and untreated animals using an ordinal scale for ranking the degree of confidence in their judgement of two unbiased observers. Psychopharmacologia 1961; 1: 141-146.
5. Lewi PJ, Niemegeers CJE. A system's approach to quantitative pharmacology. Europ. J. Pharmacol. 1970; 11: 361-370.
6. Urquhart J. Role of patient compliance in clinical pharmacokinetics. A review of recent research. Clin. Pharmacokinet. 1994; 27: 202-215.
7. Janssen PAJ. Structure-activity relationship (SAR) and drug design as illustrated with neuroleptic agents. In Encyclopaedia of Pharmacology and Therapeutics. Pergamon Press: New York, NY, 1973; 37-73.
8. Janssen PAJ, Niemegeers CJF, Schellekens KHL. Is it possible to predict the clinical efficacy of neuroleptic drugs (major tranquilliers) from animal data? Part 1. "Neuroleptic activity spectra" for rats. Arzneim. Forsch. (Drug Res.) 1965; 15: 104-117.
9. Lewi PJ. Spectral mapping, a technique for classifying biological activity profiles of chemical compounds. Arzneim. Forsch. (Drug Res.) 1976; 26: 1295-1300.
10. Wouters L, Goehlmann HW, Bijnens L, Kass SU, Molenberghs G, Lewi PJ. Graphical exploration of gene expression data: a comparative study of three multivariate methods. Biometrics 2003; 59: 1131-1139.
11. Fechner GT. Elemente der Psychophysik (1907). In Elements of Psychophysics, Davis DH (ed.). Holt, Rinehart and Winston: New York, NY, 1966.
12. Siegel S. Nonparametric Statistics for the Behavioral Sciences. McGraw-Hill: New York, NY, 1956.
13. Janssen PAJ. L'application des méthodes statistiques en pharmacie. I. Les tests de non-normalité. J. Pharmac. Belg. 1953; 35: 474-476.
14. Lewi PJ, Marsboom RP. Toxicology Reference Data - Wistar Rat. Elsevier/North Holland Biomedical Press: Amsterdam, NL, 1981.
15. Litchfield JT, Wilcoxon F. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 1949; 96: 99-113.
16. Finney DJ. Probit Analysis. Cambridge University Press: New York, NY, 1962.
17. Lewi PJ, Niemegeers CJE, Gypen LJ. First hand estimation of the median effective dose (ED50) and its confidence interval, assuming a linear log dose-response function. Janssen Pharmaceutica report, LMD123705, 1996.
18. Lewi PJ, Niemegeers CJE, Rens WG. Application of an on-line computer to pharmacological assays. Drug Inform. Bull. 1970; 4: 108-111.
19. Lewi PJ, Schaper WKA, Van Riel DG, Braet WW, Snoeckx LH, Flameng WJ, Nuyens RF. The use of a mini-computer in cardiovascular pharmacology. Arzneim. Forsch. (Drug Res.) 1973; 23: 436-441.