Practical method for the synthesis of (R)-homopipecolinic acid and (R)-homoproline esters from ω-chloroalkanoic acids and available chiral amines

Tetrahedron

Volumn 62, Issue 10, 2006, Pages 2214-2223

  Hashimoto, Norio ^a,b   Funatomi, Takashi ^b   Misaki, Tomonori ^b   Tanabe, Yoo ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b KWANSEI GAKUIN UNIVERSITY   (Japan)

Author keywords

Chiral amines; Diastereoselective reduction; Intramolecular cyclization; Keto esters

Indexed keywords

1 (1 PHENYLETHYL) 2 [(METHOXYCARBONYL)METHYLIDENE]PIPERIDINE; 1 (1 PHENYLETHYL) 2 [2(1 PHENYLETHYLAMINOCARBONYL)METHYLIDENE]PYRROLIDINE; 2,2 DIMETHYL 5 (5 CHLOROPENTANOYL) 1,3 DIOXANE 4,6 DIONE; 2,7 BIS(4,4 DIMETHYL 3,5 DIOXO 2,6 DIONECYCLOHEXYLIDENE)[1,6]DIOXETANE; 6 CHLORO 3 OXO N (1 PHENYLETHYL)HEXANAMIDE; ALKANOIC ACID; DIOXANE DERIVATIVE; METHYL 3 (1 NAPHTHYLETHYLAMINO) 6 CHLOROHEX 2 ENOATE; METHYL 3 (1 NAPHTHYLETHYLAMINO) 7 CHLOROHEPT 2 ENOATE; METHYL 3 (1 PHENYLETHYLAMINO) 6 CHLOROHEX 2 ENOATE; METHYL 3 (1 PHENYLETHYLAMINO) 7 CHLOROHEPT 2 ENOATE; PIPERIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHIRALITY; CYCLIZATION; DIASTEREOISOMER; DRUG SYNTHESIS; HYDROGENOLYSIS; PRIORITY JOURNAL; REDUCTION; STEREOCHEMISTRY;

EID: 32444442908     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2005.12.014     Document Type: Article

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