Effects of castration on the expression of brain-derived neurotrophic factor (BDNF) in the vas deferens and male accessory genital glands of the rat

Cell and Tissue Research

Volumn 323, Issue 3, 2006, Pages 513-522

  Mirabella, Nicola ^a   Squillacioti, Caterina ^a   Paone, Immacolata ^a   Ciarcia, Roberto ^a   Russo, Marco ^a   Paino, Giuseppe ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Androgens; Brain derived neurotrophic factor (BDNF); Rat (Sprague Dawley); Reverse transcription real time polymerase chain reaction; Stromal cells; Sympathetic innervation

Indexed keywords

ANDROGEN; BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA;

ACCESSORY SEX GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CASTRATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GANGLION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NEUROSECRETORY CELL; NONHUMAN; PRIORITY JOURNAL; PROSTATE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VAS DEFERENS; VESICULAR GLAND;

ANDROGENS; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASTRATION; EPITHELIAL CELLS; MALE; MUSCLE, SMOOTH; ORGAN SPECIFICITY; PROSTATE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SEMINAL VESICLES; STROMAL CELLS; VAS DEFERENS;

ANIMALIA;

EID: 32444437098     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00441-005-0084-1     Document Type: Article

References (79)

1. Abrahamsson PA (1999) Neuroendocrine cells in tumour growth of the prostate. Endocr Relat Cancer 6:503-519
2. Aloyz RS, Bamji SX, Pozniak CD, Toma JG, Atwal J, Kaplan DR, Miller FD (1998) p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors. J Cell Biol 143:1691-1703
3. Amoureux MC (1999) NT-3: an additional neurotrophin expressed in the adult rat pituitary. Endocr Res 25:295-305
4. Angelsen A, Sandvik AK, Syversen U, Stridsberg M, Waldum HL (1998) NGF-beta, NE-cells and prostatic cancer cell lines. A study of neuroendocrine expression in the human prostatic cancer cell lines DU-145, PC-3, LNCaP and TSU-pr1 following stimulation of the nerve growth factor-beta. Scand J Urol Nephrol 32:7-13
5. Arrighi S, Cremonesi F, Bosi G, Domeneghini C (2004) Endocrine-paracrine cells of the male urogenital apparatus: a comparative histochemical and immunohistochemical study in some domestic ungulates. Anat Histol Embryol 33:225-232
6. Bamji SX, Majdan M, Pozniak CD, Belliveau DJ, Aloyz R, Kohn J, Causing CG, Miller FD (1998) The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. J Cell Biol 140:911-923
7. Barbacid M (1995) Neurotrophic factors and their receptors. Curr Opin Cell Biol 7:148-155
8. Bodker A, Andersson KE, Batra S, Juhl BR, Meyhoff HH (1994) The estrogen receptor expression in the male rabbit urethra and prostate following castration. Scand J Urol Nephrol 28:113-118
9. Bonini P, Pierucci D, Cicconi S, Porzio O, Lauro R, Marlier LNJL, Borboni P (2001) Neurotrophins and neurotrophin receptor mRNAs expression in pancreatic islets and insulinoma cell lines. J Pancreas 2:105-111
10. Chaves EI de, Bussiere M, Vance DE, Campenot RB, Vance JE (1997) Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons. J Biol Chem 272:3028-3035
11. Chaves EP de, Bussiere M, Maclnnis B, Vance DE, Campenot RB, Vance JE (2001) Ceramide inhibits axonal growth and nerve growth factor uptake without compromising the viability of sympathetic neurons. J Biol Chem 276:36207-36214
12. Cockett AT, Di Sant'Agnese PA, Gopinath P, Schoen SR, Abrahamsson PA (1993) Relationship of neuroendocrine cells of prostate and serotonin to benign prostatic hyperplasia. Urology 42:512-519
13. Cohen RJ, Glezerson G, Haffejee Z (1991) Neuro-endocrine cells: a new prognostic parameter in prostate cancer. Br J Urol 68:258-262
14. Conner JM, Yan Q, Varon S (1996) Distribution of brain-derived neurotrophic factor in the rat pituitary gland. Neuroreport 7:1937-1940
15. Dalal R, Djakiew D (1997) Molecular characterization of neurotrophin expression and the corresponding tropomyosin receptor kinases (trks) in epithelial and stromal cells of the human prostate. Mol Cell Endocrinol 134:15-22
16. Di Sant'Agnese PA (1992) Neuroendocrine differentiation in human prostatic carcinoma. Hum Pathol 23:287-296
17. Di Sant'Agnese PA (1995) Neuroendocrine differentiation in prostatic carcinoma: recent findings and new concepts. Cancer 75:1850-1859
18. Di Sant'Agnese PA, Mesy Jensen KL de, Churukian CJ, Agarwal MM (1985) Human prostatic endocrine-paracrine (APUD) cells. Distributional analysis with a comparison of serotonin and neuron-specific enolase immunoreactivity and silver stains. Arch Pathol Lab Med 109:607-612
19. Dixon JE, McKinnon D (1994) Expression of the trk gene family of neurotrophin receptors in prevertebral sympathetic ganglia. Brain Res Dev Brain Res 77:177-182
20. Dobrowsky RT, Werner MH, Castellino AM, Chao MV, Hannun YA (1994) Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science 265:1596-1599
21. Ernfors P, Lee KF, Kucera J, Jaenisch R (1994) Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77:503-512
22. Geldof AA, Haarst EP van, Newling DWW (1998) Neurotrophic factors in prostate and prostatic cancer. Prostate Cancer Prostatic Dis 1:236-241
23. Gibbs RB (1998) Levels of trkA and BDNF mRNA, but not NGF mRNA, fluctuate across the estrous cycle and increase in response to acute hormone replacement. Brain Res 810:294
24. Gibbs RB (1999) Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain. Brain Res 844:20-27
25. Goodman LJ, Valverde J, Lim F, Geschwind MD, Federoff HJ, Geller AI, Hefti F (1996) Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Mol Cell Neurosci 7:222-238
26. Graham CW, Lynch JH, Djakiew D (1992) Distribution of nerve growth factor-like protein and nerve growth factor receptor in human prostatic hyperplasia and prostatic carcinoma. J Urol 147:1444-1447
27. Guate JL, Fernandez N, Lanzas JM, Escaf S, Vega JA (1999) Expression of p75 (LNGFR) and Trk neurotrophin receptors in normal and neoplastic human prostate. BJU Int 84:495-502
28. Hannestad J, Germanà A, Catania S, Laura R, Ciriaco E, Vega JA (1998) Neurotrophins and their receptors in the pigeon caecal tonsil. An immunohistochemical study. Vet Immunol Immunopathol 61:359-367
29. Harper GP, Thoenen H (1980) The distribution of nerve growth factor in the male sex organs of mammals. J Neurochem 34:893-903
30. Harper GP, Barde YA, Burnstock G, Cartairs JR, Dennison ME, Suda K, Vernon CA (1979) Guinea pig prostate is a rich source of nerve growth factor. Nature 279:160-162
31. Harper GP, Glandville RW, Thoenen H (1982) The purification of nerve growth factor from bovine seminal plasma. J Biol Chem 257:8541-8548
32. Heymach JV, Kruttgen A, Suter U, Shooter EM (1996) The regulated secretion and vectorial targeting of neurotrophins in neuroendocrine and epithelial cells. J Biol Chem 271:25430-25437
33. Hofmann HD, Unsicker K (1982) The seminal vesicle of the bull. A new and very rich source of nerve growth factor. Eur J Biochem 128:421-426
34. Huang EJ, Reichart LF (2001) Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677-736
35. Humpel C, Lindqvist E, Olson L (1993) Detection of nerve growth factor mRNA in rodent salivary glands with digoxigenin- and 33P-labeled oligonucleotides: effects of castration and sympathectomy. J Histochem Cytochem 41:703-708
36. Ickes BR, Pham TM, Sanders LA, Albeck DS, Mohammed AH, Granholm AC (2000) Long-term environmental enrichment leads to regional increases in neurotrophin levels in rat brain. Exp Neurol 164:45-52
37. Jazierski MK, Sohrabji F (2000) Region- and peptide-specific regulation of the neurotrophins by estrogen. Brain Res Mol Brain Res 85:77-84
38. Katoh-Semba R, Semba R, Kato H, Ueno M, Arakawa Y, Kato K (1994) Regulation by androgen of levels of the beta subunit of nerve growth factor and its mRNA in selected regions of the mouse brain. J Neurochem 62:2141-2147
39. Keast JR (1999) Autonomic innervation of male sex organs - an important target of circulating androgens. Behav Brain Res 105:81-92
40. Keast JR (2000) Effects of testosterone on pelvic autonomic pathways: progress and pitfalls. J Auton Nerv Syst 79:67-73
41. Keast JR, Kepper ME (2001) Differential regulation of trkA and p75 in noradrenergic pelvic autonomic ganglion cells after deafferentation of their cholinergic neighbours. Eur J Neurosci 13:211-220
42. Keast JR, Saunders RJ (1998) Testosterone has potent, selective effects on the morphology of pelvic autonomic neurons which control the bladder, lower bowel and internal reproductive organs of the male rat. Neurosci 85:543-556
43. Keast JR, Gleeson RJ, Shulkes A, Morris MJ (2002) Maturational and maintenance effects of testosterone on terminal axon density and neuropeptide expression in the rat vas deferens. Neuroscience 112:391-398
44. Kyprianou N, Isaacs JT (1988) Activation of programmed cell death in the rat ventral prostate after castration. Endocrinology 122:552-562
45. Kohn J, Aloyz RS, Toma JG, Haak-Frendscho M, Miller FD (1999) Functionally antagonistic interactions between the TrkA and p75 neurotrophin receptors regulate sympathetic neuron growth and target innervation. J Neurosci 19:5393-5408
46. Krizsan-Agbas D, Pedchenko T, Hasan W, Smith PG (2003) Oestrogen regulates sympathetic neurite outgrowth by modulating brain derived neurotrophic factor synthesis and release by the rodent uterus. Eur J Neurosci 18:2760-2768
47. Lewin GR, Barde YA (1996) Physiology of neurotrophins. Annu Rev Neurosci 19:289-317
48. Liu Y, Fowler CD, Young LJ, Yan Q, Insel TR, Wang Z (2001) Expression and estrogen regulation of brain-derived neurotrophic factor gene and protein in the forebrain of female prairie voles. J Comp Neurol 433:499-514
49. Lommatzsch M, Braun A, Mannsfeld A, Botchkarev VA, Botchkareva NV, Paus R, Fischer A, Lewin GR, Renz H (1999) Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Am J Pathol 155:1183-1193
50. Lucini C, Maruccio L, Girolamo P de, Castaldo L (2003) Brain-derived neurotrophic factor in higher vertebrate pancreas: immunolocalization in glucagon cells. Anat Embryol 206:311-318
51. MacGrogan D, Despres G, Romand R, Dicou E (1991) Expression of the beta-nerve growth factor gene in male sex organs of the mouse, rat, and guinea pig. J Neurosci Res 28:567-573
52. MacGrogan D, Saint-Andre JP, Dicou E (1992) Expression of nerve growth factor and nerve growth factor receptor genes in human tissues and in prostatic adenocarcinoma cell lines. J Neurochem 59:1381-1391
53. Martin R, Fraile B, Peinado F, Arenas MI, Elices M, Alonso L, Paniagua R, Martin JJ, Santamaria L (2000) Immunohistochemical localization of protein gene product 9.5, ubiquitin, and neuropeptide Y immunoreactivities in epithelial and neuroendocrine cells from normal and hyperplastic human prostate. J Histochem Cytochem 48:1121-1130
54. Maruccio L, Castaldo L, Girolamo P de, Lucini C (2004) Neurotrophin and Trk receptor-like immunoreactivity in the frog gastrointestinal tract. Histol Histopathol 19:349-356
55. Melck D, De Petrocellis L, Orlando P, Bisogno T, Laezza C, Bifulco M, Di Marzo V (2000) Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. Endocrinology 141:118-122
56. Mirabella N, Squillacioti C, Varricchio E, Genovese A, Paino G (2003) Innervation of vas deferens and accessory male genital glands in the water buffalo (Bubalus bubalis). Neurochemical characteristics and relationships to the reproductive activity. Theriogenology 59:1999-2016
57. Montano X, Djamgoz MB (2004) Epidermal growth factor, neurotrophins and the metastatic cascade in prostate cancer. FEBS Lett 571:1-8
58. Murer MG, Yan Q, Raisman-Vozari R (2001) Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog Neurobiol 63:71-124
59. Murray E, Malley SE, Qiao LY, Hu VY, Vizzard MA (2004) Cyclophosphamide induced cystitis alters neurotrophin and receptor tyrosine kinase expression in pelvic ganglia and bladder. J Urol 172:2434-2439
60. Patapoutian A, Reichart LF (2001) Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol 11:272-280
61. Paul A, Habib F (1998) Low-affinity nerve growth factor receptors (p75LNGFR) in human prostate tissue: stromal localisation. Urol Res 26:111-116
62. Paul AB, Grant ES, Habib FK (1996) The expression and localisation of beta-nerve growth factor (beta-NGF) in benign and malignant human prostate tisue: relationship to neuroendocrine differentiation. Br J Cancer 74:1990-1996
63. Pflug BR, Dionne C, Kaplan DR, Lynch J, Djakiew D (1995) Expression of a Trk high affinity nerve growth factor receptor in the human prostate. Endocrinology 136:262-268
64. Rodriguez R, Pozuelo JM, Martin R, Henriques-Gil N, Haro M, Arriazu R, Santamaria L (2003) Presence of neuroendocrine cells during postnatal development in rat prostate: immunohistochemical, molecular, and quantitative study. Prostate 57:176-185
65. Satoh F, Mimata H, Nomura T, Fujita Y, Sakamoto S, Hamada Y, Nomura Y (2001) Autocrine expression of neurotrophins and their receptors in prostate cancer. Int J Urol 8:S28-S34
66. Shikata H, Utsumi N, Hiramatsu M, Minami N, Nemoto N, Shikata T (1984) Immunohistochemical localization of nerve growth factor and epidermal growth factor in guinea pig prostate gland. Histochemistry 80:411-413
67. Snider WD (1994) Function of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 77:627-638
68. Sohrabji F, Miranda RC, Toran-Allerand CD (1995) Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor. Proc Natl Acad Sci USA 92:11110-11114
69. Solum DT, Handa RJ (2002) Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus. J Neurosci 22:2650-2659
70. Staack A, Kassis AP, Olshen A, Wang Y, Wu D, Carroll PR, Grossfeld GD, Cunha GR, Hayward SW (2003) Quantitation of apoptotic activity following castration in human prostatic tissue in vivo. Prostate 54:212-219
71. Tilley WD, Horsfall DJ, McGee MA, Alderman JE, Marshall VR (1987) Effects of ageing and hormonal manipulations on the level of oestrogen receptors in the guinea-pig prostate. J Endocrinol 112:139-144
72. Vittoria A, La Mura E, Cocca T, Cecio A (1990) Serotonin-, somatostatin- and chromogranin A-containing cells of the urethro-prostatic complex in the sheep. An immunocytochemical and immunofluorescent study. J Anat 171:169-178
73. Weeraratna AT, Arnold JT, George DJ, DeMarzo A, Isaacs JT (2000) Rational basis for Trk inhibition therapy for prostate cancer. Prostate 45:140-148
74. West NB, Chang CS, Liao SS, Brenner RM (1990) Localization and regulation of estrogen, progestin and androgen receptors in the seminal vesicle of the rhesus monkey. J Steroid Biochem Mol Biol 37:11-21
75. Wetmore C, Olson L (1995) Neuronal and nonneuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia suggest new intercellular trophic interactions. J Comp Neurol 353:143-159
76. Yamamoto M, Sobue G, Yamamoto K, Terao S, Mitsuma T (1996) Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3 and GDNF) and their receptors (p75NGFR, trkA, trkB and trKC) in the adult human peripheral nervous system and nonneural tissues. Neurochem Res 21:929-938
77. Yuasa H, Ono Y, Fukabori Y, Ohma C, Suzuki K, Yamanaka H (1997) Effect of sex hormones on the tissue localization of nuclear estrogen receptor positively stained cells in the seminal vesicle of immature castrated rats. Tohoku J Exp Med 81:297-309
78. Zhao GQ, Bacher M, Friedrich B, Schmidt W, Rausch U, Goebel HW, Tuohimaa P, Aumüller G (1993) Functional properties of isolated stroma and epithelium from rat ventral prostate during androgen deprivation and estrogen treatment. Exp Clin Endocrinol 101:69-77
79. Zhou XF, Rush RA (1996) Endogenous brain-derived neurotrophic factor is anterogradely transported in primary sensory neurons. Neuroscience 74:945-953