Generation of Streptomyces globisporus SMY622 strain with increased landomycin E production and it's initial characterization

Journal of Antibiotics

Volumn 57, Issue 6, 2004, Pages 383-389

  Gromyko, Oleksandr ^a   Rebets, Yuriy ^a   Ostash, Bohdan ^a   Luzhetskyy, Andriy ^a   Fukuhara, Masahiro ^b   Bechthold, Andreas ^c   Nakamura, Tatsunosuke ^b   Fedorenko, Victor ^a  

^a IVAN FRANKO NATIONAL UNIVERSITY OF LVIV   (Ukraine)

^b NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; CARBENICILLIN; ERYTHROMYCIN; GENTAMICIN; KANAMYCIN; LANDOMYCIN E; OLEANDOMYCIN; OXYGENASE; POLYKETIDE; REGULATOR PROTEIN; RIBOSOME PROTEIN; RIFAMPICIN; STREPTOMYCIN; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; FUNGAL STRAIN; FUNGUS MUTANT; GENETIC TRANSCRIPTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MUTAGENESIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; REGULATOR GENE; STREPTOMYCES; STREPTOMYCES GLOBISPORUS; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET IRRADIATION; WILD TYPE;

STREPTOMYCES GLOBISPORUS;

EID: 3242889225     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.57.383     Document Type: Article

References (19)

1. Krohn, K. & J. Rohr: Angucyclines: total syntheses, new structures and biosynthetic studies of an emerging new class of antibiotics. Top. In Curr. Chem. 188: 127-195, 1997
2. Fedorenko, V.; L. Basilia, K. Pankevych, L. Dubitska, B. Ostash, A. Luzhetskyy, O. Gromyko & H. Krugel: Genetic control of antitumor antibiotics-polyketides by actinomycetes. Bull. Inst. Agr. Microbiol. (Ukr.) 8: 27-31, 2000
3. Westrich, L.; S. Domann, B. Faust, D. Bedford, D. A. Hopwood & A. Bechthold: Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin A biosynthesis. FEMS Microbiol. Lett. 170: 381-387, 1999
4. Ostash, B.; Y. Rebets, V. Yuskevich, A. Luzhetskyy, V. Tkachenko & V. Fedorenko: Targeted disruption of Streptomyces globisporus lndF and lndL cyclase genes involved in landomycin E biosynthesis. Folia Microbiol (Praha) 48: 484-488, 2003
5. Ostash, B.; U. Rix, L. L. Remsing, T. Liu, F. Lombo, A. Luzhetskky, O. Gromyko, C. Wang, A. F. Brana, C. Mendez, J. A. Salas, V. Fedorenko & J. Rohr: Generation of new landomycins by combinatorial biosynthetic manipulation of the IndGT4 gene of the landomycin E cluster in S. globisporus. Chem. & Biol. 11: 547-555, 2004
6. Okamoto-Hosoya, Y.; T. Hosaka & K. Ochi: An aberrant protein synthesis is linked with antibiotic overproduction in rpsL mutants of Streptomyces coelicolor A3(2). Microbiology 149: 3299-3309, 2003
7. Norimasa, T.; T. Hosaka, J. Xu, H. Hu, N. Otake & K. Ochi: Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus. Appl. Environ. Microbiol. 69: 6412-6417, 2003
8. Zavorotnaia, S.; V. A. Fedorenko & V. N. Danilenko: Genetic instability of the feature of streptomycin resistance in Streptomyces erythraeus. Antibiot. Khimioter. (Russ) 35: 18-21, 1990
9. Rebets, Y.; B. Ostash, A. Luzhetskyy, D. Hoffmeister, A. Brana, C. Mendez, J.A. Salas, A. Bechthold & V. Fedorenko: Production of landomycins in strains Streptomyces globisporus 1912 and S. cyanogenus S136 is regulated by genes encoding putative transcriptional activators. FEMS Microbiol. Lett. 222: 149-153, 2003
10. Kieser, T.; M. J. Bibb, M. J. Buttner, K. F. Chater & D. A. Hopwood: Practical Streptomyces genetics. John Innes Foundation, Norwich, United Kingdom, 2000
11. Sambrook, J. & D. W. Russell: Molecular cloning, a laboratory manual. 3rd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y, 2001
12. Altschul, S. F.; T. L. Madden, A. A. Schaffer, J. Zhang, Z. Zhang, W. Miller & D. J. Lipman: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25: 3389-3402, 1997
13. Luzhetskii, A. N.; B. O. Ostash & V. O. Fedorenko: Intergeneric conjugation Escherichia coli-Streptomyces globisporus 1912 using integrative plasmid pSET152 and its derivatives. Russian Journal of Genetics. 37: 1123-1 129, 2001
14. Kyung, Y.-S.; W.-S. Hu & D. H. Sherman: Analysis of temporal and spatial expression of the CcaR regulatory element in the cephamycin C biosynthetic pathway using green fluorescent protein. Mol. Microbiol. 40: 530-541, 2001
15. Shima, J.; A. Hesketh, S. Okamoto, S. Kawamoto & K. Ochi: Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2). J. Bacteriol. 178: 7276-7284, 1977
16. Demidchuk, I. A.; L. M. Golets & V. A. Fedorenko: Characteristics of Streptomyces kanamyceticus mutants resistant to aminoglycoside antibiotics. Antibiot. Khimioter. (Russ) 41:15-20, 1996
17. Rebets, Y.; B. Ostash, A. Luzhetskyy, S. Kushnir, M. Fukuhara, A. Bechthold, T. Nakamura & V. Fedorenko: DNA binding activity of LndI protein and temporal expression of it's gene that upregulates landomycin E production in Streptomyces globisporus 1912. J. Bacteriol. in press
18. Hutchinson, C. R.: Biosynthetic studies of daunorubicin and tetracenomycin C. Chem. Rev. 97: 2525-2535, 1997
19. Hu, H. & K. Ochi: Novel approach for improving the productivity of antibiotic producing strains by inducing combined resistant mutations. Appl. Environ. Microbiol. 67: 1885-1892, 2001