Stable isotope-mass spectrometric measurements of molecular fluxes in vivo: Emerging applications in drug development

Current Opinion in Molecular Therapeutics

Volumn 6, Issue 3, 2004, Pages 249-264

  Hellerstein, Mark K ^a   Murphy, Elizabeth ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Heavy water; Mass isotopomer distribution analysis; Metabolic networks; Metabolic pathways; Molecular kinetics; Phenotype; Systems biology

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIESTROGEN; ANTIMITOTIC AGENT; ANTIRETROVIRUS AGENT; BROXURIDINE; CYCLOOXYGENASE 2 INHIBITOR; DEOXYRIBONUCLEOSIDE; DEUTERIUM OXIDE; DNA; FINASTERIDE; INTERLEUKIN 2; ISOTOPE; LIPID; PROTEIN; RNA DIRECTED DNA POLYMERASE INHIBITOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; BACTERIAL METABOLISM; BREAST CANCER; BREAST EPITHELIUM; CANCER PREVENTION; CELL DEATH; CELL PROLIFERATION; COLON CANCER; COLON MUCOSA; DNA SYNTHESIS; DRUG TARGETING; GENETIC ANALYSIS; GENETIC TRAIT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VIVO STUDY; INBORN ERROR OF METABOLISM; ISOTOPE LABELING; KINETICS; KNOCKOUT MOUSE; LIPOGENESIS; MASS SPECTROMETRY; MEASUREMENT; MOLECULAR PROBE; NONHUMAN; PHENOTYPE; PROSTATE CANCER; PROTEIN SYNTHESIS; REVIEW; TRANSGENIC MOUSE;

ANIMALS; DEUTERIUM OXIDE; HUMANS; ISOTOPE LABELING; MASS SPECTROMETRY; METABOLISM; MONITORING, PHYSIOLOGIC; SYSTEMS ANALYSIS;

EID: 3242886416     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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