Uterine Smooth Muscle Tumors in Potbellied Pigs (Sus scrofa) Resemble Human Fibroids: A Potential Animal Model

Toxicologic Pathology

Volumn 32, Issue 4, 2004, Pages 402-407

  Mozzachio, Kristie ^a   Linder, Keith ^a   Dixon, Darlene ^b  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

animal model; fibroids; leiomyoma; porcine; potbellied pig; Uterus

Indexed keywords

ACTIN; EOSIN; HEMATOXYLIN; SMOOTH MUSCLE ACTIN; UNCLASSIFIED DRUG;

ABDOMINAL DISTENSION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INCIDENCE; CELL STRUCTURE; CLINICAL FEATURE; CONTROLLED STUDY; DATA BASE; GENITAL SYSTEM DISEASE; HYPERPLASIA; HYSTERECTOMY; IMMUNOHISTOCHEMISTRY; LEIOMYOSARCOMA; MEDICAL RECORD; NONHUMAN; OVARIECTOMY; PATHOGENESIS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SARCOMA; STAINING; SWINE; TISSUE SECTION; UNDIFFERENTIATED CARCINOMA; UNITED STATES; UTERUS CANCER; UTERUS HORN; UTERUS MYOMA; UTERUS SARCOMA; UTERUS TUMOR; VAGINA BLEEDING;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LEIOMYOMA; MEDICAL RECORDS; RETROSPECTIVE STUDIES; SMOOTH MUSCLE TUMOR; SUS SCROFA; UTERINE NEOPLASMS;

ANIMALIA; SUIDAE; SUS; SUS SCROFA;

EID: 3242878829     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230490440880     Document Type: Article

References (28)

1. Akkermans, J.P.W.M., and van Beusekom, W.J. (1984). Tumors and tumor-like lesions in the genitalia of sows. Vet Q 6, 90-6.
2. Andersen, M.C., Robboy, S.J., and Russell, P. (2002a). Uterine smooth muscle tumors. In Pathology of the Female Reproductive Tract (M. C. Andersen, S. J. Robboy and P. Russell, eds.), pp. 389–414. Harcourt Publishers, London, UK.
3. Andersen, M.C., Robboy, S.J., Russell, P., and Morse, A. (2002b). The normal endometrium. In Pathology of the Female Reproductive Tract (M. C. Andersen, S. J. Robboy and P. Russell, eds.), pp. 241–65. Harcourt Publishers, London, UK.
4. Anderson, L.J., and Sandison, A.T. (1969). Tumours of the female genitalia in cattle, sheep, and pigs found in a British abattoir survey. J Comp Pathol 79, 53-63.
5. Buttram, V.C. Jr., and Reiter, R.C. (1981). Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril 36, 433-45.
6. Cramer, S.F., Horiszny, J.A., and Leppert, P. (1995). Epidemiology of uterine leiomyomas. With an etiologic hypothesis. J Reprod Med 40, 595-600.
7. Cramer, S.F., and Patel, A. (1990). The frequency of uterine leiomyomas. Am J Clin Pathol 94, 435-8.
8. Crum, C.P. (1999). The female genital tract. In Pathologic Basis of Disease (R. S. Cotran, V. Kumar and T. Collins, eds.), pp. 1035–91. WB Saunders, Philadelphia, Pennsylvania.
9. Everitt, J.I., Wolf, D.C., Howe, S.R., Goldsworthy, T.L., and Walker, C. (1995). Rodent model of reproductive tract leiomyomata: clinical and pathological features. Am J Path 146, 1556-67.
10. Field, K.J., Griffith, J.W., and Lang, C.M. (1989). Spontaneous reproductive tract leiomyomas in aged guinea-pigs. J Comp Path 101, 287-94.
11. Flake, G.P., Andersen, J., and Dixon, D. (2003). Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect 111, 1037-54.
12. Gambone, J.C., Reiter, R.C., Lench, J.B., and Moore, J.G. (1990). The impact of a quality assurance process on the frequency and confirmation rate of hysterectomy. Am J Obstet Gynecol 163, 545-50.
13. Houston, K.D., Hunter, D.S., Hodges, L.C., and Walker, C.L. (2001). Uterine leiomyomas: mechanisms of tumorigenesis. Tox Path 29, 100-4.
14. Howe, S.R., Gottardis, M.M., Everitt, J.I., Goldsworthy, T.L., Wolf, D.C., and Walker, C. (1995). Rodent model of reproductive tract leiomyomata: establishment and characterization of tumor-derived cell lines. Am J Path 146, 1568-79.
15. Lipschutz, A., and Vargas, L. (1941). Structure and origin of uterine and extragenital fibroids induced experimentally in the guinea pig by prolonged administration of estrogens. Cancer Res 1, 236-49.
16. The Merck Veterinary Manual, 8th edition (1998). Potbellied pigs (S. E. Aiello, ed., A. Mays, assoc. ed.), pp. 1379–80. National Publishing, Inc., Philadelphia, Pennsylvania.
17. Munday, J.S., and Stedman, N.L. (2002). Uterine leiomyomas in two Vietnamese pot-bellied pigs (Sus scrofa). Vet Pathol 39, 580-3.
18. Newbold, R.R., DiAugustine, R.P., Risinger, J.I., Everitt, J.I., Walmer, D.K., Parrott, E.C., and Dixon, D. (2000). Advances in uterine leiomyoma research: conference overview, summary, and future research recommendations. Environ Health Perspect 108(suppl 5), 769-73.
19. Newbold, R.R., Moore, A.B., and Dixon, D. (2002). Characterization of uterine leiomyomas in CD-1 mice following developmental exposure to diethylstilbestrol (DES). Tox Path 30, 611-6.
20. Reeves, D.E. (1993). History and development of miniature pet pigs in North America. In Care and Management of Miniature Pet Pigs (D. E. Reeves, ed.), pp. 1–6. Veterinary Practice Publishing Company, Santa Barbara, CA.
21. Robboy, S.J., Bentley, R.C., Butnor, K., and Anderson, M.C. (2000). Pathology and pathophysiology of uterine smooth-muscle tumors. Environ Health Perspect 108(suppl. 5), 779-84.
22. Stewart, E.A. (2001). Uterine fibroids. Lancet 357, 293-8.
23. Swindle, M.M. (1998). Surgery, Anesthesia, and Experimental Techniques in Swine. Iowa State University Press, Ames.
24. Vollenhoven, B.J., Lawrence, A.S., and Healy, D.L. (1990). Uterine fibroids: a clinical review. Br J of Obstet Gynaecol 97, 285-98.
25. Von Winterfeldt, K. (1964). Leiomyoma in the broad ligament of the uterus of a pig. Dtsch Tierarztl Wochenschr 71, 70-2.
26. Wakamatsu, N., Harmon, B., and Munday, J. (2003). Case presentation at the Southeastern Veterinary Pathology Conference, Tifton, Georgia.
27. Werdin, R., and Wold, K. (1976). Uterine carcinoma in a sow. Vet Pathol 13, 451-2.
28. Yuan, Y.D., and Carlson, R.G. (1987). Structure, cyclic change, and function, vagina and vulva, rat. In Genital System, Monographs on Pathology of Laboratory Animals, International Life Sciences Institute (T. C. Jones, U. Mohr and R. D. Hunt, eds.), pp. 161–8. Springer-Verlag, Heidelberg, Germany.