Synthesis and biological evaluation of new 4,5-disubstituted-thiazolyl amides, derivatives of 4-hydroxy-piperidine or of 4-N-methyl piperazine

Molecules

Volumn 8, Issue 6, 2003, Pages 472-479

  Geronikaki, A ^a   Hadjipavlou Litina, D ^a   Chatziopoulos, C ^a   Soloupis, G ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Anti inflammatories; Antioxidants; Lipoxygenase inhibitors; Thiazolyl amides

Indexed keywords

AMIDE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CARRAGEENAN; CHEMICAL COMPOUND; ENZYME INHIBITOR; LIPOXYGENASE INHIBITOR; PIPERAZINE; PIPERIDINE DERIVATIVE; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; CALCULATION; CHEMICAL INTERACTION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONFERENCE PAPER; DRUG ACTIVITY; ENZYME ACTIVITY; EVALUATION; INFLAMMATION; MATHEMATICAL COMPUTING; MOUSE; NONHUMAN; PAW EDEMA; SYNTHESIS;

EID: 3242877443     PISSN: 14203049     EISSN: None     Source Type: Journal    
DOI: 10.3390/80600472     Document Type: Conference Paper

References (11)

1. Shanbag, V.R.; Crider, M.A; Gohkale, R.; Harpalani, A.; Dick, R. M. Ester and amide prodrugs of obuprofen and naproxen: synthesis, anti-inflammatory activity, and gastrointestinal toxicity J. Pharm. Sci. 1992, 81, 149-153
2. Lazer, E. S.; Wong, H.C.; Possanza, G.; Graham, A. G.; Farina, P. R. Anti-inflammatory 2,6-Di-tert-butyl-4-(2-arylethenyl)phenols. J. Med. Chem. 1989,32, 100-104.
3. Geronikaki A.; Hadjipavlou-Litina, D. Synthesis of some new aryloxy/aroyl-2-amino-1,3-thiazole derivatives with anti-inflammatory. Arzneim. Forsc./Drug Res. 1996, 46, 1134-1138
4. Geronikaki, A.; Hadjipavlou-Litina, D. Lipophilicity and biological studies of some 2-(amino-acetylamino)-thiazole derivatives with anti-inflammatory. Pharmazie, 1993, 48, 948-949
5. Geronikaki, A., Theophilidis, G. Synthesis of 2-(aminoacetylamino) thiazole derivatives and comparison of their local anaesthetic activity by the method of action potential. Eur. J. Med. Chem. 1992, 27, 1-9
6. Klein, S. M.; Cohen, G.; Cederbaum, A. I. Production of formaldehyde during metabolism of dimethyl sulfoxide by hydroxyl radical generating systems. Biochemistry, 1981, 20, 6006-6012
7. Nash, T. The colorimetric estimation of formaldehyde by means of the Hantzch reaction. Biochem. J., 1953, 55, 416-421
8. Blois, M.S. Antioxidant determination by the use of a stable free radical. Nature (London) 1958, 181, 1199-1200
9. Sircar, J.C.; Schwender, C.F.; Johnson, E.A. Synthesis and structure-activity relationships of anti-inflammatory 9,10-dihydro-9-oxo-2- acridine-alkanoic acids and 4-(2-carboxyphenyl)amino-benzenealkanoic acids. Prostaglandins, 1983, 25, 393
10. Suzuki, T.; Kudo, Y. Automatic log p estimation based on combineed additive modelling methods. J. Comput.-Aided Mol. Design, 1990, 4, 155-198
11. Clog P. Biobyte Corp. Claremont Ca 91711 USA.