Organ procurement in experimental pancreas transplantation with minimal microcirculatory impairment

European Surgical Research

Volumn 36, Issue 4, 2004, Pages 185-191

  Drognitz, O ^a   Von Dobschuetz, E ^a   Kissler, H ^b   Liu, X ^a   Obermaier, R ^a   Neeff, H ^a   Hopt, U T ^a   Benz, S ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Apoptosis; Intravital fluorescence microscopy; Ischemia reperfusion injury; Microcirculation; Organ procurement; Pancreas transplantation

Indexed keywords

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; APOPTOSIS; ARTICLE; CAPILLARY DENSITY; COMPARATIVE STUDY; CONTROLLED STUDY; DNA STRAND BREAKAGE; FLUORESCENCE MICROSCOPY; LEUKOCYTE; LIGAMENT; MALE; MICROCIRCULATION; NICK END LABELING; NONHUMAN; PANCREAS; PANCREAS TRANSPLANTATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REPERFUSION; SURGICAL TECHNIQUE; VENULE;

ANASTOMOSIS, SURGICAL; ANIMALS; APOPTOSIS; IN SITU NICK-END LABELING; MALE; MICROCIRCULATION; PANCREAS; PANCREAS TRANSPLANTATION; RATS; RATS, INBRED LEW; REPERFUSION INJURY; TISSUE AND ORGAN PROCUREMENT;

EID: 3242798312     PISSN: 0014312X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000078851     Document Type: Article

References (30)

1. Fernandez-Cruz L, Sabater L, Gilabert R, Ricart MJ, Saenz A, Astudillo E: Native and graft pancreatitis following combined pancreas-renal transplantation. Br J Surg 1993;80:1429-1432.
2. Stratta RJ, Taylor RJ, Lowell JA, Bynon JS, Cattral M, Langnas AN, Shaw BW Jr: Selective use of Sandostatin in vascularized pancreas transplantation. Am J Surg 1993;166:598-604.
3. Benz S, Bergt S, Obermaier R, Wiessner R, Pfeffer F, Schareck W, Hopt UT: Impairment of microcirculation in the early reperfusion period predicts the degree of graft pancreatitis in clinical pancreas transplantation. Transplantation 2001;71:759-763.
4. Obermaier R, Benz S, Kortmann B, Benthues A, Ansorge N, Hopt UT: Ischemia/reperfusioninduced pancreatitis in rats: A new model of complete normothermic in situ ischemia of a pancreatic tail-segment. Clin Exp Med 2001;1:51-59.
5. D'Alessandro AM, Stratta RJ, Southard JH, Kalayoglu M, Belzer FO: Agonal hepatic arterial vasospasm. Surg Gynecol Obstet 1989;169:324-328.
6. Imagawa DK, Olthoff KM, Yersiz H, Shackleton CR, Colquhoun SD, Shaked A, Busuttil RW: Rapid en bloc technique for pancreas-liver procurement: Improved early liver function. Transplantation 1996;61:1605-1609.
7. Klar E, Kraus T, Osswald BR, Bleyl J, Fernandes L, Mehrabi A, Newman W, Gebhard MM, Herfarth C, Otto G: Induktion einer Mikrozirkulationsstörung durch in situ Hiluspräparation bei Lebertransplantation. Zentralbl Chir 1995;120:482-485.
8. Lee S, Tung KS, Koopmans H, Chandler JG, Orloff MJ: Pancreaticoduodenal transplantation in the rat. Transplantation 1972;13:421-425.
9. Bassi D, Kollias N, Fernandez-del Castillo C, Foitzik T, Warshaw AL, Rattner DW: Impairment of pancreatic microcirculation correlates with the severity of acute experimental pancreatitis. J Am Coll Surg 1994;179:257-263.
10. Kerner T, Vollmar B, Menger MD, Waldner H, Messmer K: Determinants of pancreatic microcirculation in acute pancreatitis in rats. J Surg Res 1996;62:165-171.
11. Plusczyk T, Rathgeb D, Westermann S, Feifel G: Somatostatin attenuates microcirculatory impairment in acute sodium taurocholate-induced pancreatitis. Dig Dis Sci 1998;43:575-585.
12. Vollmar B, Janata J, Yamauchi JI, Menger MD: Attenuation of microvascular reperfusion injury in rat pancreas transplantation by Larginine. Transplantation 1999;67:950-955.
13. Hoffmann TF, Leiderer R, Waldner H, Arbogast S, Messmer K: Ischemia reperfusion of the pancreas: A new in vivo model for acute pancreatitis in rats. Res Exp Med (Berl) 1995;195:125-144.
14. Menger MD, Vollmar B: Role of microcirculation in transplantation. Microcirculation 2000;7:291-306.
15. Freude B, Masters TN, Robicsek F, Fokin A, Kostin S, Zimmermann R, Ullmann C, Lorenz-Meyer S, Schaper J: Apoptosis is initiated by myocardial ischemia and executed during reperfusion. J Mol Cell Cardiol 2000;32:197-208.
16. Kohli V, Selzner M, Madden JF, Bentley RC, Clavien PA: Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver. Transplantation 1999;67:1099-1105.
17. Fischer S, Cassivi SD, Xavier AM, Cardella JA, Cutz E, Edwards V, Liu M, Keshavjee S: Cell death in human lung transplantation: apoptosis induction in human lungs during ischemia and after transplantation. Ann Surg 2000;231:424-431.
18. Ikeda H, Suzuki Y, Suzuki M, Koike M, Tamura J, Tong J, Nomura M, Itoh G: Apoptosis is a major mode of cell death caused by ischaemia and ischaemia/reperfusion injury to the rat intestinal epithelium. Gut 1998;42:530-537.
19. Drognitz O, Liu X, Benz S, Obermaier R, Herb T, Schareck W, Hopt UT: Ischemia/reperfusion injury induces acinar cell apoptosis in experimental pancreas transplantation. Transplant Proc 2002;34:2361.
20. Lee S, Scott M, de Macedo AR: Pancreaticoduodenal transplantation in the rat: A technique update. Transplantation 1986;42:327-329.
21. Schmid-Schoenbein GW, Zweifach BW, Kovalcheck S: The application of stereological principles to morphometry of the microcirculation in different tissues. Microvasc Res 1977;14:303-317.
22. Di Cataldo A, Puleo S, Li DG, Guastella T, Trombatore G, La Greca G, Leone F, Latteri F, Rodolico G: Pancreas transplantation in the rat using Lee's technique: A reliable model in experimental microsurgery. J Invest Surg 1989;2:159-167.
23. Grewal HP, Garland L, Novak K, Gaber L, Tolley EA, Gaber AO: Risk factors for postimplantation pancreatitis and pancreatic thrombosis in pancreas transplant recipients. Transplantation 1993;56:609-612.
24. Menger MD, Plusczyk T, Vollmar B: Microcirculatory derangements in acute pancreatitis. J Hepatobiliary Pancreat Surg 2001;8:187-194.
25. Vollmar B, Janata J, Yamauchi J, Wolf B, Heuser M, Menger MD: Exocrine, but not endocrine, tissue is susceptible to microvascular ischemia/reperfusion injury following pancreas transplantation in the rat. Transpl Int 1999;12:50-55.
26. Mayer H, Schmidt J, Thies J, Ryschich E, Gebhard MM, Herfarth C, Klar E: Characterization and reduction of ischemia/reperfusion injury after experimental pancreas transplantation. J Gastrointest Surg 1999;3:162-166.
27. Schemmer P, Schoonhoven R, Swenberg JA, Bunzendahl H, Thurman RG: Gentle in situ liver manipulation during organ harvest decreases survival after rat liver transplantation: Role of Kupffer cells. Transplantation 1998;65:1015-1020.
28. Schemmer P, Connor HD, Arteel GE, Raleigh JA, Bunzendahl H, Mason RP, Thurman RG: Reperfusion injury in livers due to gentle in situ organ manipulation during harvest involves hypoxia and free radicals. J Pharmacol Exp Ther 1999;290:235-240.
29. Obermaier R, Benz S, von Dobschuetz E, Drognitz O, Schareck W, Jonas L, Messmer K, Hopt UT: Characterization of microcirculatory disturbance in a novel model of pancreatic ischemia-reperfusion using intravital fluorescence- microscopy. Pancreas 2002;25:142-148.
30. Timmermann W, Schang T, Stoffregen C, Schubert G, Thiede A: Development and perspectives of experimental pancreas transplantation in the rat. Microsurgery 1990;11:133-139.