A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets

Bioconjugate Chemistry

Volumn 15, Issue 4, 2004, Pages 799-806

  Mulder, Willem J M ^a   Strijkers, Gustav J ^a   Griffioen, Arjan W ^b   Van Bloois, Louis ^c   Molema, Grietje ^d   Storm, Gert ^c   Koning, Gerben A ^c,e   Nicolay, Klaas ^a  

^a EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

^e DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSIS; ENDOTHELIAL CELLS; FLUORESCENCE; FLUORESCENCE MICROSCOPY; LIPOSOMES; MONOCLONAL ANTIBODIES; PARAMAGNETISM;

CELL-BE; CELL/B.E; CELL/BE; CONTRAST-ENHANCED; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; IMMUNOLIPOSOMES; MOLECULAR MARKER; MOLECULAR TARGETS; PEGYLATED; SELECTINS;

MAGNETIC RESONANCE IMAGING;

CD62 E ANTIGEN; CELL ADHESION MOLECULE; CYTOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FLUORESCENT IMMUNOLIPOSOME; IMMUNOLIPOSOME; LIPOSOME; MOLECULAR MARKER; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY E SELECTIN; PADGEM PROTEIN; PEGYLATED PARAMAGNETIC IMMUNOLIPOSOME; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC IMAGING; ENDOTHELIUM CELL; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR PROBE; MOLECULAR TARGET; NON INVASIVE MEASUREMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTEIN EXPRESSION; UMBILICAL VEIN;

EID: 3242793428     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc049949r     Document Type: Article

References (42)

1. Weissleder, R., and Mahmood, U. (2001) Molecular imaging. Radiology 219, 316-333.
2. Aime, S., Dastru, W., Crich, S. G., Gianolio, E., and Mainero, V. (2002) Innovative magnetic resonance imaging diagnostic agents based on paramagnetic Gd(III) complexes. Biopolymers 66, 419-428.
3. Aime, S., Cabella, C., Colombatto, S., Geninatti, C. S., Gianolio, E., and Maggioni, F. (2002) Insights into the use of paramagnetic Gd(III) complexes in MR-molecular imaging investigations. J. Magn Reson. Imaging 16, 394-406.
4. Sipkins, D. A., Cheresh, D. A., Kazemi, M. R., Nevin, L. M., Bednarski, M. D., and Li, K. C. (1998) Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. Nat. Med. 4, 623-626.
5. Sipkins, D. A., Gijbels, K., Tropper, F. D., Bednarski, M., Li, K. C., and Steinman, L. (2000) ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging. J. Neuroimmunol. 104, 1-9.
6. Lanza, G. M., Yu, X., Winter, P. M., Abendschein, D. R., Karukstis, K. K., Scott, M. J., Chinen, L. K., Fuhrhop, R. W., Scherrer, D. E., and Wickline, S. A. (2002) Targeted antiproliferative drug delivery to vascular smooth muscle cells with a magnetic resonance imaging nanoparticle contrast agent: implications for rational therapy of restenosis. Circulation 106, 2842-2847.
7. Huber, M. M., Staubli, A. B., Kustedjo, K., Gray, M. H., Shih, J., Fraser, S. E., Jacobs, R. E., and Meade, T. J. (1998) Fluorescently detectable magnetic resonance imaging agents. Bioconjugate Chem. 9, 242-249.
8. Mastrobattista, E., Koning, G. A., and Storm, G. (1999) Immunoliposomes for the targeted delivery of antitumor drugs. Adv. Drug Deliv. Rev. 40, 103-127.
9. Metselaar, J. M., Mastrobattista, E., and Storm, G. (2002) Liposomes for intravenous drug targeting: design and applications. Mini. Rev. Med. Chem. 2, 319-329.
10. Allen, T. M. Liposomes. (1997) Opportunities in drug delivery. Drugs 54 Suppl 4, 8-14.
11. Allen, T. M. (1994) Long-circulating (sterically stabilized) liposomes for targeted drug delivery. Trends Pharmacol. Sci. 15, 215-220.
12. Allen, T. M., Hansen, C., Martin, F., Redemann, C., and Yau-Young, A. (1991) Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. Biochim. Biophys. Acta 1066, 29-36.
13. Koning, G. A., Schiffelers, R. M., and Storm, G. (2002) Endothelial cells at inflammatory sites as target for therapeutic intervention. Endothelium 9, 161-171.
14. Storrs, R. W., Tropper, F. D., Li, H. Y., Song, C. K., Sipkins, D. A., Kuniyoshi, J. K., Bednarski, M. D., Strauss, H. W., and Li, K. C. (1995) Paramagnetic polymerized liposomes as new recirculating MR contrast agents. J. Magn Reson. Imaging 5, 719-724.
15. Leclercq, F., Cohen-Ohana, M., Mignet, N., Sbarbati, A., Herscovici, J., Scherman, D., and Byk, G. (2003) Design, synthesis, and evaluation of gadolinium cationic lipids as tools for biodistribution studies of gene delivery complexes. Bioconjugate Chem. 14, 112-119.
16. Glogard, C., Stensrud, G., Hovland, R., Fossheim, S. L., and Klaveness, J. (2002) Liposomes as carriers of amphiphilic gadolinium chelates: the effect of membrane composition on incorporation efficacy and in vitro relaxivity. Int. J. Pharm. 233, 131-140.
17. Griffioen, A. W., Damen, C. A., Blijham, G. H., and Groenewegen, G. (1996) Tumor angiogenesis is accompanied by a decreased inflammatory response of tumor-associated endothelium. Blood 88, 667-673.
18. Everts, M., Koning, G. A., Kok, R. J., Asgeirsdottir, S. A., Vestweber, D., Meijer, D. K., Storm, G., and Molema, G. (2003) In vitro cellular handling and in vivo targeting of E-selectin-directed immunoconjugates and immunoliposomes used for drug delivery to inflamed endothelium. Pharm. Res. 20, 64-72.
19. Spragg, D. D., Alford, D. R., Greferath, R., Larsen, C. E., Lee, K. D., Gurtner, G. C., Cybulsky, M. I., Tosi, P. F., Nicolau, C., and Gimbrone, M. A., Jr. (1997) Immunotargeting of liposomes to activated vascular endothelial cells: a strategy for site-selective delivery in the cardiovascular system. Proc. Natl. Acad. Sci. U.S.A. 94, 8795-8800.
20. Griffioen, A. W., Coenen, M. J., Damen, C. A., Hellwig, S. M., van Weering, D. H., Vooys, W., Blijham, G. H., and Groenewegen, G. (1997) CD44 is involved in tumor angiogenesis; an activation antigen on human endothelial cells. Blood 90, 1150-1159.
21. Brooks, P. C., Montgomery, A. M., Rosenfeld, M., Reisfeld, R. A., Hu, T., Klier, G., and Cheresh, D. A. (1994) Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157-1164.
22. Dias, S., Hattori, K., Heissig, B., Zhu, Z., Wu, Y., Witte, L., Hicklin, D. J., Tateno, M., Bohlen, P., Moore, M. A., and Rafii, S. (2001) Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias. Proc. Natl. Acad. Sci. U.S.A. 98, 10857-10862.
23. Witte, L., Hicklin, D. J., Zhu, Z., Pytowski, B., Kotanides, H., Rockwell, P., and Bohlen, P. (1998) Monoclonal antibodies targeting the VEGF receptor-2 (Flk1/KDR) as an antiangiogenic therapeutic strategy. Cancer Metastasis Rev. 17, 155-161.
24. Koning, G. A., Morselt, H. W., Velinova, M. J., Donga, J., Gorter, A., Allen, T. M., Zalipsky, S., Kamps, J. A., and Scherphof, G. L. (1999) Selective transfer of a lipophilic prodrug of 5-fluorodeoxyuridine from immunoliposomes to colon cancer cells. Biochim. Biophys. Acta 1420, 153-167.
25. Rouser, G., Fkeischer, S., and Yamamoto, A. (1970) Two-dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids 5, 494-496.
26. Petterson, G. L. (1977) A simplification of the protein assay method of lowry et al. which is more generally applicable. Anal. Biochem. 83, 346-356.
27. Mastrobattista, E., Koning, G. A., van Bloois, L., Filipe, A. C., Jiskoot, W., and Storm, G. (2002) Functional characterization of an endosome-disruptive peptide and its application in cytosolic delivery of immunoliposome-entrapped proteins. J. Biol. Chem. 277, 27135-27143.
28. Caravan, P., Ellison, J. J., McMurry, T. J., and Lauffer, R. B. (1999) Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications. Chem. Rev. 99, 2293-2352.
29. Griffioen, A. W., Damen, C. A., Martinotti, S., Blijham, G. H., and Groenewegen, G. (1996) Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: the role of angiogenic factors. Cancer Res. 56, 1111-1117.
30. Tello, R. and Crewson, P. E. (2003) Hypothesis testing II: means. Radiology 227, 1-4.
31. Griffioen, A. W. and Molema, G. (2000) Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol. Rev. 52, 237-268.
32. Blankenberg, S., Barbaux, S., and Tiret, L. (2003) Adhesion molecules and atherosclerosis. Atherosclerosis 170, 191-203.
33. Kang, H. W., Josephson, L., Petrovsky, A., Weissleder, R., and Bogdanov, A., Jr. (2002) Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture. Bioconjugate Chem. 13, 122-127.
34. Bhatti, M., Chapman, P., Peters, M., Haskard, D., and Hodgson, H. J. (1998) Visualising E-selectin in the detection and evaluation of inflammatory bowel disease. Gut 43, 40-47.
35. Wang, Y. X., Hussain, S. M., and Krestin, G. P. (2001) Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging. Eur. Radiol. 11, 2319-2331.
36. Bonnemain, B. (1998) Superparamagnetic agents in magnetic resonance imaging: physicochemical characteristics and clinical applications. A review. J. Drug Target. 6, 167-174.
37. Hansen, C. B., Kao, G. Y., Moase, E. H., Zalipsky, S., and Allen, T. M. (1995) Attachment of antibodies to sterically stabilized liposomes: evaluation, comparison and optimization of coupling procedures. Biochim. Biophys. Acta 1239, 133-144.
38. Phillips, N. C., Gagne, L., Tsoukas, C., and Dahman, J. (1994) Immunoliposome targeting to murine CD4+ leucocytes is dependent on immune status. J. Immunol. 152, 3168-3174.
39. Koning, G. A., Morselt, H. W., Gorter, A., Allen, T. M., Zalipsky, S., Kamps, J. A., and Scherphof, G. L. (2001) Pharmacokinetics of differently designed immunoliposome formulations in rats with or without hepatic colon cancer metastases. Pharm. Res. 18, 1291-1298.
40. Allen, T. M., Brandeis, E., Hansen, C. B., Kao, G. Y., and Zalipsky, S. (1995) A new strategy for attachment of antibodies to sterically stabilized liposomes resulting in efficient targeting to cancer cells. Biochim. Biophys. Acta 1237, 99-108.
41. Phospholipids Handbook. (1993) Marcel Dekker, New York.
42. Janssen, A. P., Schiffelers, R. M., ten Hagen, T. L., Koning, G. A., Schraa, A. J., Kok, R. J., Storm, G., and Molema, G. (2003) Peptide-targeted PEG-liposomes in anti-angiogenic therapy. Int. J. Pharm. 254, 55-58.